Türk Köpeklerinde SAD B19'un Zararsızlık Testleri

Öz

Dünya Sağlık Örgütü'nün isteklerine göre, köpeklerin kuduza karşı ağız yolu ile aşılanması için örnek aşı virusu SAD B19, yerel Türk köpeklerinde zararsızlık yönünden test edildi SAD B 19 un haftalıktan küçük yavru köpeklerde oral ve parenteral uygulamadan sonra tmamen zararsız olduğu gösterilmiştir. SAD B19 ile intracerebral aşılanan ergin köpeklerde 21 günlük gözlem süresince kuduza ait hitbir klinik belirti görülmemiştir. SAD B19 ile oral , intracerabral veya parenteral yollarla aşılandıktan sonra farklı zamanlarda salya numuneleri toplandı. Yetişkin ve yavru köpeklerden alınan salya swablarında virus tespit edilemedi.

Anahtar Kelimeler

• SAD B 19
• Köpek
• Orhan AYLAN
• 1998
• Etlik Veteriner Mikrobiyoloji Dergisi

Safety tests with SAD B19 in Turkish dogs

Öz

The candidate vaccine-virus SAD B 19 for oral vaccination of dogs against rabies was tested in local Turkish dogs in respect of safety, according to the requirements of the World Health Organization. It was shown that SAD B 19 was completely innocuous for puppies less than 10 weeks of age after oral and parenteral application. Adult dogs vaccinatecl i.c. with SAD B 19 did not show any clinical symptoms of rabies during the observation period of 40 days. Also. no excretian of vaccine-virus could be detected in saliva swabs taken from adult dogs and puppies. The saliva swabs were collected at different intervals after the vaccine virus SAD B 1 9 was administered orally. intracerebrally or by the parenteral route.

Kaynakça

1. Blancou J, Meslin F-X (1996) Moclifiecllive-virus rabies vaccines for oral immunization of carnivores. In: Laboratory techniques in rabies. 4th ed. (eds . Meslin F-X, Kaplan MM, Koprowski H) 324-337. World Health Organization, Geneva.
2. Haddad N, Ben Khelifa R, Matter H, Kharmachi H, Aubert MFA, W andeler Al, Blancou J ( 1 994) Ass ay of oral vaccination of dogs against rabies in Tunisia with the vaccinal strain SADa erıı· Vaccine, 12: 307-309.