Staphylococcus Aureus Ekzotoksinleri

Öz

Staphylococcus aureus, konakçılarında kolonize olabilmek ve hastalık oluşturabilmek için çok çeşitli ekzotoksinlere sahiptir. Bu ekzotoksinlerin esas görevi konakçı dokularını, bakterinin gelişmesine uygun hale getirmektir. Bu derlemede, S aureus tarafından salgılanan ekzotoksinlerin ve hemolizinlerin yapılarından ve biyolojik fonksiyonlarından bahsedilmiştir.

Anahtar Kelimeler

• Etlik Veterinerlik Mikrobiyoloji Dergisi
• Staphylococcus Aureus
• Ekzotoksinler
• Hamit Kaan MÜŞTAK
• Ömer M.ESENDAL
• 2008

Exotoxins of Staphylococcus Aureus

Öz

Staphylococcus aureus has a wide variety of exoproteins that contribute to its ability to colonize and cause disease in its hosts. The main function of these proteins are to convert local tissues into suitable condition for bacterial development. This review addresses the structure and biological functions of the exotoxins and hemolysins secreted by S.aureus.

Kaynakça

1. Amagi M, Matsuyosih N, Wang ZH, Andl C, Stanley JR, (2000). Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets demoglein-1. Nat Med. 6, 1275-1277.
2. Balaban N, Rasooly A, (2000). Staphylococcal enterotoxins. Int J Food Microbiol. 61, 1-10.
3. Bonventre PF, Heeg H, Edwards III CD, Cullen CM, (1995). A mutation at histidine residue 135 of toxic shock syndrome toxin yields an immunogenic protein with minimal toxicity. Infect Immun. 63, 509-515.
4. Dinges MM, Orwin PM, Schlievert PM, (2000). Exotoxins of Staphylococcus aureus. Clin Microbiol Rev. 13 (1), 16-34.
5. Gray GS, Kehoe M, (1984). Primary sequence of the α- toxin gene from Staphylococcus aureus Wood 46. Infect Immun. 46, 615-618.
6. Harris TD, Grossman D, Kappler JW, Marrack P, Rich RR, Betley MJ, (1993). Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins. Infect Immun. 61, 3175-3183.
7. Konig B, Prevost G, Konig W, (1997). Composition of staphylococcal bi-component toxins determines pathophysiological reactions. J Med Microbiol. 46, 479-485.
8. Ladhani S, Joannou CL, Lochric DP, Evans RW, Poston SM, (1999). Clinical, microbial and biochemical aspects of the exfoliative toxins causing staphylococcal scalded skin syndrome. Clin Microbiol Rev. 12, 224-242.

9. Ladhani S, (2001). Recent developments in staphylococcal scalded skin syndrome. Clin Microbiol Infect. 7, 301-307.
10. Ladhani S, (2003). Understanding the mechanism of action of the exfoliative toxins of Staphylococcus aureus. FEMS Immunol Med Microbiol. 39 (2), 181-189.
11. Melish ME, Glasgow LA, (1970). The staphylococcal scalded skin syndrome: development of an experimental model. New Engl J Med. 282, 1114-1119.
12. Prevost G, Cribier B, Couppie P, et al. (1995). Panton- Valentine leukocidin and gamma hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities. Infect Immun. 63, 4121-4129.
13. Schlievert PM, Bohach GA, Ohlendorf DH, et al. (1995). Molecular structure of staphylococcus and streptococcus süperantigens. J Clin Immunol. 15, 4S-10S.
14. Siqueira JA, Speeg-Schatz C, Frehas FIS, Sahel J, Monteil H, Prevost G, (1997). Channel-forming leucotoxins from Staphylococcus aureus cause severe inflammatory reactions in a rabbit eye model. J Med Microbiol. 46, 486-494.
15. Tibana A, Rayman K, Akhtar M, Szabo R, (1987). Thermal stability of enterotoxins A, B, and C in a buffered system. J Food Prot. 50, 239-242.
16. Van den Bussche RA, Lyon JD, Bohach GA, (1993). Molecular evolution of the staphylococcal and streptococcal pyrogenic toxin gene family. Mol Phylogenet Evol. 2 (4), 281-292.