Tavuk ve Hindilerde Xylazin hidroklorürle Premedikasyon Etomidat, Ketamin Hidroklorür ve Propofol ile Sağlanan Anestezinin Klinik Parametreler Açısından Araştırılması

Öz

Bu çalışma kanatlı hayvanlarda genel anestezide emin, etkili, komplikasyon riski bulunmayan veya düşük düzeyde bulunan bir anestezik drogla çalışma gereği hissedildiğinden, bu ihtiyaca ışık tutması amaçlanarak yapılmıştır. Çalışmada; etomidat grubu için 6 tavuk, 6 hindi, propofol grubu için 6 tavuk, 6 hindi, ketamin grubu için 6 tavuk ve 6 hindi olmak üzere toplam 18 tavuk ile 18 hindi kullanıldı. Premedikasyon amacıyla xylazine hidrochloride (Rompun- Bayer) 1-2mg/kg kullanıldı. Premedikasyondan sonra ilk gruba 5 mg/kg etomidat (Johnson&Johnson) ikinci gruba 8 mg/kg propofol (Diprivan-Abbott™) vena subcutenea ulnarisden verildi. Üçüncü gruba 50 mg/kg dozunda ketamin hidrokloride (Ketasol-İnterhas) pectoral kas içine verildi. Parametrelere anestezi öncesi, anestezi sırası ve anesteziden 24 saat sonrasında bakıldı. Klinik parametrelerden kalp vurum sayısı, solunum sayısı ve beden ısısına bakıldı.Ketalar ile propofol tavuk ve hindi gruplarında kalp vurum sayısındaki değişiklikler istatistiki olarak p<0.05’e göre anlamlı bulundu. Sonuç olarak, etomidat kanatlılarda kullanılırken solunum sayısında azalmalara neden olabileceğinden akciğer rahatsızlığı olanlarda bu durumun dikkate alınması yararlı olacaktır. Ketamin ve propofol kanatlılarda kullanılırken hem kalp vurum sayısında hem de solunum sayısında azalışlar gözleneceğinden kalp ve solunum rahatsızlığı olanlarda bu durumun göz önünde bulundurulmalıdır.

Anahtar Kelimeler

• Etlik Veteriner Mikrobiyoloji Dergisi
• Etomidat
• Hindi
• Ketalar
• Propofol
• Tavuk
• Özlem KARDOĞAN
• Abuzer TAŞ
• 2014

A Research on Chickens and Turkeys Premedicated With Xylazine Hydrochloride and Anesthesia With Etomitade, Ketamine Hydrochloride and Propofol About Clinical Parameters

Öz

In this study, the goal was to shed light on the need of working with an anesthetic drug that is safe, effective and low or no any complications during general anesthesia in avian animals. The study etomidate for a group of six chickens, six turkeys, propofol for a group of six chickens, six turkeys, ketalar for a group six chickens, six turkeys and of a total of eighteen chickens and eighteen turkeys were used. For the purpose for premedication, xylazine (rompun-bayer) 1-2 mg/kg was used. After premedication, 5 mg/kg etomidate (Johnson&Johnson) to the first group and 8 mg/kg propofol (Diprivan-Abbott™ to the second group was administered via vena ulnaris subcutenea. To the third group 50 mg/kg ketamine hydrochloride (Ketasol-İnterhas) was given into the pectoral. Parameters were investegated before induction of anesthesia, during and 24 hours after anesthesia.The number of clinical parameters, heart rate and body temperature, respiratory rate were monitored.In groups of propofol and ketalar chicken and turkey changes heart ratea statistical value of p<0.05 was found to be significant.As a result, etomidate while using in avians may lead to decrease in respiration rate and therefore this issue should be taken into consideration. Because there will be a decrease in both the number of heart rate and respration while ketamin and propofol are used for winged animals, this fact must be taken into consideration while studying with the ones that have heart and respiration problems

Kaynakça

1. Ajadi RA, Olajide B, Kasali A, Folashade Makinde, Adetiike I, Adeleye JA, Oyewusi and Olukayode G Akintunde, (2009). Effects of Midazolam on Ketamine-Xylazine Anesthesia in Guinea Fowl (Numida meleagris galeata). Journal of Avian Medicine and Surgery 23(3):199-204. Association of Avian Veterinarians.
2. Anonim, (2009). Erişim adresi :http://www.gençveteriner.com/ kanatlilar/kuşlarin-anestezisi,Erişim tarihi:2009.
3. Anteplioğlu H, Temizer M, (1968). Veteriner Anesteziyoloji. AÜ Basım Evi, Vet. Fak. Yay., 232, 23-25.
4. Aslanbey D, (1986). Veteriner Operasyon Bilgisi, Ankara Üniversitesi Veteriner Fakültesi Yayınları 411, cilt 1, ikinci baskı, A.Ü. Basımevi, Ankara, 124-126.
5. Bayram D, (2005). Sıçan karaciğeri üzerine tiyopental sodyum, propofol, etomidate ve midazolam isimli anestezik maddelerine etkisinin ışık mikroskobik düzeyde incelenmesi. S. D. Ü. Tıp Fak. Sağ. Bil. Ens. Yük. Lis. Tez. Isparta.
6. Benedikt B, Korbel R, Stiehl J, (1998). Untersuchungen zurperianästhetischen Stabilisierung der Körpertemperaturbei Haustauben (Columba livia L, 1789, var. dom.). Proceedings of the XI Tagung über Vogelkrankheiten. München, Germany. pp. 218-230.
7. Christensen J, Fosse R.T, Halvorsen OJ, (1987). Comperison of varioss anesthetic regimens in the domestic fowl. AJVR, 48, 11, 1649-1657.
8. Degernes LA, Kreeger TJ, Maiidsager R, Redig PT, (1988). Ketamine-xylazine anesthesia in red-tailed hawks with antagonism by yohimbine.J Wildl Dis,24, 22-326.

9. Dorcas O. Schaefer, (1997). Anesthesia and Analgesia in nontraditional laboratory animal species. chapter 15. 341-346.
10. Dziaman R, Hajek G, Kłyszejko B, (2010). Effect of 2-phenoxyethanol and etomidate on cardiac and respiratory functions and behaviour of common carp, Cyprinus carpiol (Actinopterygii, Cypriniformes, Cyprinidae), during general anaesthesia. Acta Ichthyol. Piscat. 40, 1, 37-43.
11. Fitzgerald G, Cooper JE,(1990).Prelimary studies on the use of propofol in the domestic pigeon (Columbia livia). Res Vet Sci, 49, 334-338.
12. Gandomani MJ, Tamadon A, Mehdizadeh A, Ataran HR, (2009). Comparasion of Different Ketamine-Xylazine Combinations for Prolonged Anaesthesia in Budgerigars. Online veterinary journal. 4 (1), 34.
13. Giuliano Q Mostachio, Luciana D de-Oliveira, Aulus C Carciofi, Wilter R R Vicente, (2008). The effects of anesthesia with a combination of intramuscular xylazine-diazepamketamine on heart rate, respiratory rate and cloacal temperature in roosters. Veterinary Anaesthesia and Analgesia. 35, 232-236. Brazil.
14. Gold MI, Abraham EC, Herrington C, (1987). Controlled investigation of propofol, thiopentone and methohexitone.Can J Anesth34, 478-483.
15. Hawkins M, Wright BD, Tell LA, (2000). Anestheticand cardiopulmonary effects of propofol in red-tailedhawks (Buteo jamaicensis) and great horned owls (Bubo virginianus). Proc Assoc Avian Vet, 27-228.
16. Işık G, (2006). İntravenöz Anestezikler.Erişim adresi : http:// www.lokman.cu.edu.tr/anestezi/anestezinot, Erişim tarihi: 2006.
17. Kamiloğlu A, Atalan G ve Kamiloğlu NN, (2008). Comparison of intraosseous and intramuscular drug administration for induction of anaesthesia in domestic pigeons. R Vet Sci, 85, 1, 171-175.
18. Kılıç N and Paşa S, (2009). Cardiopulmonary effects of propofol compared with those of a medetomidine-ketamine combination in the common buzzards (Buteo buteo). Revue Med Vet, 160, 3, 154-159.
19. Langan JN, Ramsay EC, Balckford TJ, (2000). Cardiopulmonary and sedative effects of intramuscular medetomidine- ketamine and intravenous propofol in ostriches (struthio camelus).J Avian Med Surg, 14, 2-7.
20. Langlois I, Harvey RC, Jones MP and Schumacher J, (2003). Cardiopulmonary and Anesthetic Effects of Isoflurane and Propofol in Hispaniolan Amazon Parrots (Amazona ventralis) Journal of Avian Medicine and Surgery, 17, 1, 4-10. Association of Avian Veterinarians
21. Lierz M, (2012). Anesthesia and analgesia in birds. Topics in medicine and surgery. Journal of Exotic Pet Medicine, 21, pp 44-58.
22. Lukasik VM, Gentz EJ, Erb HN, (1997). Cardiopulmonary Effects of Propofol Anesthesia in Chickens (Gallus gallus domesticus) Journal of Avian Medicine and Surgery, 11, 2, 93-97.
23. Lyon Lee, (2006). Intravenous Anesthetic Agents & Dissociatives 8-14 Veterinary Surgery I, VMEDAnesthesiology 7412.
24. Machin KL, Caulkett NA, (1998). Cardiopulmonary effectsof propofol and medetomidine-midazolam-ketamine combination in mallard ducks(Anas platyrhynchos). Am J Vet Res, 59, 598- 602.
25. Machin KL, Caulkett NA, (1999). Cardiopulmonary effects of propofol infusion in canvasback ducks (Aythyavalisineria). J Avian Med Surg, 13, 167-172.
26. Machin KL, Caulkett NA, (2000). Evaluation of isoflurane and propofol anesthesia for intraabdominal transmitter placement in nesting female canvasback ducks, 36,2, 324-334.
27. Maiti SK, Tiwary R, Vasan P, Dutta A, (2006). Xylazine, diazepam and midazolam premedicated ketamine anaesthesia in white Leghorn cockerels for typhlectomy J S Afr Vet Assoc. 77, 1, 12-18.
28. Müller K, Judith Holzapfel and Leo Brunnberg, (2011). Total intravenous anaesthesia by boluses or by continuous rate infusion of propofol in mute swans. Vet Anaesth Analg, 38,4, 286-291.
29. Nagel ML, Muir WW, Nguyen K, (1979). Comparison of the cardiopulmonary effects of etomidate and thiamylal in dogs. Am J Vet Res, 40: 193.
30. Ocal T, (2002). Diğer Ajanlar IV. Çukurova Anestezi Günleri. Çukurova Üni. Tıp Fak. Anest. ABD. ADANA.Erişim adresi: http://www.med.cu.edu.tr/ anestezi/iv_cag/diger.htm. Erişim tarihi: 2002
31. Paddleford RR., Harvey RC, (1999). Alpha-2 agonists and antagonists. The Veterinary Clinics of North America. Small Animal Practice, 29, 737-745.
32. Pascoe PJ, İlkiw J.E, Haskins SC, Patz DP, (1992). Cardiopulmonary effects of etomidate in hypovolemic dogs. Am J Vet Res, 53,11, 2178-2182.
33. Perk C, Güzel Ö, Gülanber EG, (2002). Etomidate/Alfentanil Anaesthesia in Dogs and Its Effects on Pulse Oxymeter, Electrocardiography and Haematological Parameters.Turk J Vet Anim Sci, 26, 1021-1024.
34. Redig PT, Roush JC, (1987). Orthopaedic and soft tissue surgery in raptorial species. In: Fowler, M.E. (Ed.), Zoo and Wild Animal Medicine. WB Saunders, Philadelphia, pp. 246-253.
35. Rembert MS, Smith JA, Hosgood G, (2001). Comparison of traditional thermal support devices with the forced-air warmer system in anesthetized Hispaniolan Amazon parrots(Amazona ventralis). Avian Med Surg, 15, 187-193.
36. Samour JH, Jones DM, Knight JA, Howlett JC, (1984). Comparative studies of the use of some injectable anes-thetic agents in birds.Vet Rec, 115, 6-11.
37. Schumacher J, Citino SB, Hernandez K, Hutt J, Dixon B, (1997). Cardiopulmonary and anesthetic effects of propofol in wild turkeys. Am J Vet Res, Sep, 58, 9, 1014-1017.
38. Thurman JC, Tranquli WS, Benson GJ, (1996). Lumb and Jones’ Veterinary Anesthesia. Third Edition. Williams and Wilkins. Baltimore, 2-4.
39. Topal A, (2005). Veteriner Anestezi. Nobel&Güneş Yayınları.
40. Uzun M, Yıldız S, Atalan G, Kaya M, Sulu N, (2003). Effects of Medetomidine-Ketamine Combination Anaesthesia on Electrocardiograhic Findings, Body Temperature, and Heart and Respiratory Rates in Domestic Pigeons.Turk J Vet Anim Sci, 27, 377-382.
41. Valverde A, Bienzle D, Simth DA, (1993). Intraosseous cannulation and drug administration for induction of anesthesia in chickens.Vet Surg, 22, 3, 240-244.