Şap hastalığı (FMD) ve üç gün hastalıklarına (BEF) karşı eş zamanlı aşılanmış sığırlarda bağışıklık yanıt

Öz

Sığırların üç hastalığı (BEF) virüsü, artropod kaynaklı bir rabdovirüs olup, sığır ve mandalarda akut ateşli enfeksiyona sebep olur. Şap hastalığı (FMD), memelilerin oldukça bulaşıcı bir viral hastalığıdır ve hassas çift tırnaklı hayvanlarda ciddi ekonomik kayıplara neden olma konusunda büyük bir potansiyele sahiptir. Şap ve BEF aşıları, her iki hastalığın birlikte görüldüğü ülkelerde yaygın olarak kullanılmaktadır. Bu çalışma, BEF ve FMD aşıları ile eş zamanlı olarak aşılanan sığırların immünolojik yanıtını belirlemek amacıyla yapılmıştır. Bu amaçla sığırlar bu çalışmada tekli Şap aşısı grubu (Grup 1; n=10), tekli BEF aşısı grubu (Grup 2; n=10), BEF+Şap ile eş zamanlı aşılı grup (Grup 3; n=10) ve aşısız kontrol grubu (Grup 4; n=10) olmak üzere 4 gruba ayrıldı. Grup 2 ve 3'teki sığırlara ilk aşılamalardan sonra booster BEF aşısı uygulandı. Çalışma sonucu aşısız sığırların kan serumlarında aşılamanın 30. ve 60. günlerinde BEF ve FMD virüsüne karşı nötralize edici antikor titrelerinde artış olmamasına rağmen, aşılanmış sığırlarda istatistiksel olarak koruyucu nötralize edici antikor seviyelerinde önemli artışlar tespit edilmiştir. Sonuç olarak bu çalışma ile sığırlarda her iki hastalıkla mücadelede BEF ve FMD aşılarının aynı anda uygulanabileceği gösterilmiştir.

Anahtar Kelimeler

• FMDV
• BEFV
• aşı
• bağışıklık
• sığır

Immune response in cattle simultaneously vaccinated with foot and mouth disease (FMD) and bovine ephemeral fever vaccines (BEF)

Öz

Bovine ephemeral fever (BEF) virus is an arthropod-borne rhabdovirus and causing an acute febrile illness disease in cattle and water buffalo. Foot-and-mouth disease (FMD) is a highly infectious viral disease of mammals and has a great potential for causing severe economic loss in susceptible cloven-hoofed animals. FMD and BEF vaccines are widely used in countries where both diseases are seen together. This study was carried out to determine the immunological response of cattle simultaneously vaccinated with BEF and FMD vaccines. For this purpose, the cattle were divided into 4 groups in this study as single FMD vaccination group (Group 1; n=10), single BEF vaccination group (Group 2; n=10), BEF+FMD simultaneously vaccinated group (Group 3; n=10) and unvaccinated control group (Group 4; n=10). After the first vaccinations, booster BEF vaccine was applied to the cattle in groups 2 and 3. Although there was no increase in the neutralizing antibody titers against BEF and FMD virus in the blood serums of unvaccinated cattle on the 30th and 60th days of vaccination, There were significant increases in statistically protective neutralizing antibody levels in the vaccinated cattle. As a result, it was demonstrated with this study that BEF and FMD vaccines can be applied simultaneously to combat both diseases in cattle.

Anahtar Kelimeler

• FMDV
• BEFV
• vaccine
• immunity
• cattle

Kaynakça

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