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Pesticides and the silent threat: Potential risks to animal and human health

Yıl 2025, Cilt: 36 Sayı: 1, 82 - 91, 24.07.2025
https://doi.org/10.35864/evmd.1638844

Öz

Pesticides are chemicals used against pests in agricultural control, veterinary medicine, and public health. Although pesticides are used for pest control, increasing crop productivity, and preventing vector-borne diseases, their excessive and unconscious use can lead to serious toxic effects on animal and human health. Humans and animals can be indirectly exposed to food, feed, water, air, and soil containing pesticide residues. There is also direct exposure through the application of pesticides used in ectoparasite control to humans and animals. Residues of pesticides and/or their metabolites can be found in vegetables, fruits, cereals, and animal products such as meat, milk, and eggs. The presence of pesticides and their metabolites has also been shown in biological samples such as blood, urine, and faeces from humans and animals and in environmental samples such as water, sediment, and soil. In order to reduce the use of pesticides and their harmful effects on health, the use of chemical pesticides should be reduced as much as possible and minimised through Good Agricultural Practices and Integrated Pest Management practices. Natural and environmentally friendly alternative methods such as biological control, biopesticides, semiochemicals, and transgenic crops should be preferred instead. Public awareness on the hazards of pesticides should be raised. Awareness should be raised among pesticide applicators, and certified courses should be made compulsory. The frequency of inspections and controls by official authorities should be increased. Human-animal-environmental health should be considered as a whole, and all relevant professional groups should approach the issue with the awareness of One Health.

Kaynakça

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Pestisitler ve Sessiz Tehlike: Hayvan ve İnsan Sağlığı için Potansiyel Risk

Yıl 2025, Cilt: 36 Sayı: 1, 82 - 91, 24.07.2025
https://doi.org/10.35864/evmd.1638844

Öz

Pestisitler tarımsal mücadele, veteriner hekimlik ve halk sağlığı alanında zararlılara karşı kullanılan kimyasal maddelerdir. Pestisitler haşere mücadelesinde, ürün verimliliğinin artmasında ve vektör kaynaklı hastalıkların önlenmesinde kullanılmasına rağmen aşırı ve bilinçsiz kullanımı hayvan ve insan sağlığı üzerinde ciddi toksik etkilere yol açabilir. İnsan ve hayvanlar pestisit kalıntılarını içeren gıda, yem, su, hava ve toprakla dolaylı olarak maruz kalabilirler. Ayrıca ektoparazit mücadelesinde kullanılan pestisitlerin insanlara ve hayvanlara uygulanması yoluyla doğrudan maruziyet de söz konusudur. Pestisit ve/veya metabolitlerinin kalıntılarına sebze, meyve ve tahıllar ile et, süt, yumurta gibi hayvansal ürünler rastlanabilmektedir. İnsan ve hayvanlardan alınan kan, idrar, dışkı gibi biyolojik örnekler ile su, sediment, toprak gibi çevresel örneklerde de pestisit ve metabolitlerinin varlığı gösterilmiştir. Pestisit kullanımı ve buna bağlı olarak sağlık üzerine zararlı etkilerini azaltmak için öncelikli olarak kimyasal pestisitlerin kullanımı mümkün olduğunca azaltılmalı, İyi Tarım Uygulamaları ve Entegre Haşere Yönetimi uygulamalarıyla en aza indirilmelidir. Bunların yerine biyolojik kontrol, biyopestisitler, semiokimyasallar ve transgenik ürünler gibi doğal ve çevre dostu alternatif yöntemler tercih edilmelidir. Pestisitlerin zararlarıyla ilgili toplumsal farkındalık artırılmalıdır. Pestisit uygulaması yapan kişiler bilinçlendirilmeli uygulayıcılara sertifikalı kurslar zorunlu hale getirilmelidir. Resmi Otoritelerce denetim ve kontrollerin sıklığı artırılmalıdır. İnsan-hayvan-çevre sağlığı bir bütün olarak ele alınmalı, ilgili tüm meslek grupları konuya Tek Sağlık bilinciyle yaklaşmalıdır.

Etik Beyan

Derleme niteliğinde olduğu için herhangi bir izne gerek bulunmamaktadır.

Kaynakça

  • Kaynaklar Ahmad MF, Ahmad FA, Alsayegh AA, Zeyaullah M, AlShahrani AM, Muzammil K, Saati A A, Wahab S, Elbendary EY, Kambal N. (2024) Pesticides Impacts on Human Health and the Environment with Their Mechanisms of Action and Possible Countermeasures. Heliyon. 10(7), e29128.
  • Aksoy A, Dervisoglu M, Güvenç D, Gul O, Yazici F, Atmaca E. (2013) Levels of Organochlorine Pesticide Residues in Butter Samples Collected from the Black Sea Region of Turkey. Bull Environ Contam Toxicol. 90(1), 110-115.
  • Aksoy A, Güvenç D, Yavuz O, Das YK, Atmaca E. (2012) Seasonal Variation of Polychlorinated Biphenyls and Organochlorine Pesticide Levels of Sea and Cultured Farm Fish in the Samsun Region of Turkey. Bull Environ Contam Toxicol. 88(6), 842-849.
  • Ali RN, Mehdi TM, Eqani SMASS, Javeed AH, Covaci AN. (2013) Organohalogenated Contaminants (OHCs) in the Serum and Hair of Pet Cats and Dogs: Biosentinels of Indoor Pollution. Sci Total Environ. 449, 29-36.
  • Ali S, Ullah MI, Sajjad A, Shakeel Q, Hussain A. (2018) Environmental and Health Effects of Pesticide Residues. Inamuddin Ahamed MI, Lichtfouse E. eds. Sustainable Agriculture Reviews. Springer Cham, USA. p. 3-14.
  • Al-Saleh I, Al-Doush I, Alsabbaheen A, Mohamed GED, Rabbah A. (2012) Levels of DDT and Its Metabolites in Placenta, Maternal and Cord Blood and Their Potential Influence on Neonatal Anthropometric Measures. Sci Total Environ. 416, 62-74.
  • Anadón A, Martínez-Larrañaga M, Martínez M. (2009) Use and Abuse of Pyrethrins and Synthetic Pyrethroids in Veterinary Medicine. Vet J. 182(1), 7-20.
  • Anderson SE, Meade BJ. (2014) Potential Health Effects Associated with Dermal Exposure to Occupational Chemicals. Environ Health Insights. 8(1), S15258.
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  • Güvenç D, Kabak YB, Atmaca E, Aksoy A, Güvenç T. (2013b) Biological Significance of the Overexpression of HSP70 and Alpha B-Crystallin in Rat Substantia Nigra Exposed to Different Doses of Permethrin. Arhiv Za Higijenu Rada I Toksikologiju. 64, 47-55.
  • Güvenç D. (2024) Gıdalardaki Pestisitler ve Risk Değerlendirmesi. Filazi A., Şireli UT. eds. Gıda Toksikolojisi. Nobel, Türkiye. p. 439-486.
  • Harley KG, Marks AR, Bradman A, Barr DB, Eskenazi B. (2008) DDT Exposure, Work in Agriculture, and Time to Pregnancy Among Farmworkers in California. J Occup Environ Med. 50(12), 1335-1342.
  • Henneberger PK, Liang X, London SJ, Umbach DM, Sandler DP, Hoppin JA. (2014) Exacerbation of Symptoms in Agricultural Pesticide Applicators with Asthma. Int Arch Occup Environ Health. 87, 423-432.
  • Hepsağ F, Kizildeniz T. (2021) Pesticide Residues and Health Risk Appraisal of Tomato Cultivated in Greenhouse from the Mediterranean Region of Turkey. Environ Sci Pollut Res Int. 28(18), 22551-22562.
  • Huffling K. (2006) The Effects of Environmental Contaminants in food on Women’s Health. JMWH. 51(1), 19-25. Jaacks LM, Staimez LR. (2015) Association of Persistent Organic Pollutants and Non-Persistent Pesticides with Diabetes and Diabetes-related Health Outcomes in Asia: A systematic review. Environ Inter. 76, 57-70.
  • Kaur N, Swain SK, Banerjee BD, Sharma T, Krishnalata T. (2019) Organochlorine Pesticide Exposure As a Risk Factor for Breast Cancer in Young Indian Women: A case–control study. South Asian J Cancer. 8(4), 212-214.
  • Kaur R, Choudhary D, Bali S, Bandral SS, Singh V, Ahmad MA. (2024) Pesticides: An Alarming Detrimental to Health and Environment. Sci Total Environ. 915, 170113.
  • Kim KH, Kabir E, Jahan SA. (2017) Exposure to Pesticides and the Associated Human Health Effects. Sci Total Environ. 575, 525-535.
  • King AM, Aaron CK. (2015) Organophosphate and Carbamate Poisoning. Emerg Med Clin. 33(1), 133-151.
  • Kojima H, Sata F, Takeuchi S, Sueyoshi T, Nagai T. (2011) Comparative Study of Human and Mouse Pregnane X Receptor Agonistic Activity in 200 Pesticides using in vitro reporter Gene Assays. Toxicol. 280(3), 77-87.
  • Kuzukiran O, Yurdakok-Dikmen B, Sevin S, Sireli UT, Iplikcioglu-Cil G, Filazi A. (2018) Determination of Selected Endocrine Disruptors in Organic, Free-Range, And Battery-Produced Hen Eggs and Risk Assessment. Environ Sci Pollut Res Int. 25(35), 35376-35386.
  • Li ZM, Robinson M, Kannan K. (2022) An Assessment of Exposure to Several Classes of Pesticides in Pet Dogs and Cats from New York, United States. Environ Int. 169, 107526.
  • Lorsirigool A, Sudjaroen Y, Kulnides N. (2022) Abuse of Chemical Substances Cause Poisoning in Dogs and Cats: A review. IJFMT, 16(4), 137-143.
  • Meenakshi M, Sharon Prabhakar SP, Bhawana Mittal BM, Anita Sharma AS, Gothecha VK. (2012) A short review on how pesticides affect human health. J. Ayurvedic Herb Med. 2(5), 935-946.
  • Meftaul IM, Venkateswarlu K, Dharmarajan R, Annamalai P, Megharaj M. (2020) Pesticides in the Urban Environment: A Potential Threat that Knocks at the Door. Sci Total Environ. 711, 134612.
  • Mehrpour O, Karrari P, Zamani N, Tsatsakis AM, Abdollahi M. (2014) Occupational Exposure to Pesticides and Consequences on Male Semen and Fertility: A Review. Toxicol Lett. 230(2), 146-156.
  • Nakayama SM, Morita A, Ikenaka Y, Mizukawa H, Ishizuka M. (2019) A review: Poisoning by Anticoagulant Rodenticides in Non-target Animals Globally. J Vet Med Sci. 81(2), 298-313.
  • Ortega-García JA, Aguilar-Ros E, Ares-Segura S, Agüera-Arenas JJ, Pernas-Barahona A, de Pipaón MS. (2021)
  • Occupational Exposures, Diet and Storing: Recommendations to Reduce Environmental Pollutants in Breastfeeding. AEP. 94(4), 261.
  • Ossola R, Farmer D. (2024) The Chemical Landscape of Leaf Surfaces and Its Interaction with the Atmosphere. Chem Rev. 124(9), 5764-5794.
  • Pan J, Liu P, Yu X, Zhang Z, Liu, J. (2024) The Adverse Role of Endocrine Disrupting Chemicals in the Reproductive System. Front Endocr. 14, 1324993.
  • Parks CG, D’Aloisio AA, Sandler DP. (2018) Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-onset Rheumatoid Arthritis in Women. Am J Epidemiol. 187(2), 214-223.
  • Pezzoli G, Cereda E. (2013) Exposure to Pesticides or Solvents and Risk of Parkinson Disease. Neurol. 80(22), 2035-2041.
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  • Poppenga RH, Oehme FW. (2010) Pesticide Use and Associated Morbidity and Mortality in Veterinary Medicine. In Hayes' Handbook of Pesticide Toxicology. Elsevier.p. 285-301.
  • Rother HA. (2018) Pesticide Labels: Protecting Liability or Health?–Unpacking “Misuse” of Pesticides. Curr Opin Environ Sci Health. 4, 10-15.
  • Saldana TM, Basso O, Hoppin JA, Baird DD, Knott C, Blair A, Alavanja MC, Sandler DP. (2007) Pesticide Exposure and Self-reported Gestational Diabetes Mellitus in the Agricultural Health Study. Diabetes Care. 30(3), 529-534.
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  • Shekhar C, Khosya R, Thakur K, Mahajan D, Kumar R, Kumar S, Sharma AK. (2024) A Systematic Review of Pesticide Exposure, Associated Risks, and Long-Term Human Health Impacts. Toxicol Rep. 101840.
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  • Trabert B, Chen Z, Kannan K, Peterson CM, Pollack AZ, Sun L. (2015) Persistent Organic Pollutants (POPs) and Fibroids: Results from the ENDO Study. JESEE. 25(3), 278-285.
  • Ulutaş OK, Çok İ, Darendeliler F, Aydin B, Çoban A. Henkelmann B, Schramm KW. (2015) Blood Concentrations and Risk Assessment of Persistent Organochlorine Compounds in Newborn Boys in Turkey. A pilot study. ESPR. 22, 19896-19904.
  • van der Werf HM. (1996) Assessing the Impact of Pesticides on the Environment. Agric Ecosyst Environ. 60(2), 81-96.
  • Wahlang B. (2018) Exposure to Persistent Organic Pollutants: Impact on Women’s Health. REVEH. 33(4), 331-348.
  • Wilhoit L. (2018) History of Pesticide Use Reporting in California. Zhang M, Jackson S, Robetson MA, Zeıss MS. eds. Managing and Analyzing Pesticide Use Data for Pest Management, Environmental Monitoring, Public Health, and Public Policy. American Chemical Society Publications, USA. p. 3-14.
  • Wise CF, Hammel SC, Herkert NJ, Ospina M, Calafat AM, Breen M, Stapleton HM. (2022) Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring. Environ Sci Technol. 56, 1149-1161.
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  • World Health Organization (WHO). (1990) Public Health Impact of Pesticides Used in Agriculture. Erişim adresi: http://apps.who.int/iris/bitstream/handle/10665/39772/9241561394.pdf;jsessionid=D11167B0AE3FDA438D22789BC9470B6E?sequence=1, Erişim tarihi: 01.04.2024.
  • World Health Organization (WHO). (2024) One Health. Erişim adresi: https://www.who.int/news-room/fact-sheets/detail/one-health, Erişim tarihi: 17.08.2024.
Toplam 92 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Farmakoloji
Bölüm Derleme
Yazarlar

Dilek Güvenç 0000-0003-0036-0914

Sedat Gökmen 0000-0002-4793-3030

Sinem İnal 0000-0002-2552-5159

Gönderilme Tarihi 12 Şubat 2025
Kabul Tarihi 28 Nisan 2025
Yayımlanma Tarihi 24 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 36 Sayı: 1

Kaynak Göster

APA Güvenç, D., Gökmen, S., & İnal, S. (2025). Pestisitler ve Sessiz Tehlike: Hayvan ve İnsan Sağlığı için Potansiyel Risk. Etlik Veteriner Mikrobiyoloji Dergisi, 36(1), 82-91. https://doi.org/10.35864/evmd.1638844


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