Araştırma Makalesi
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The Effect of Parity, Lactation Period, and Milk Yield on Metabolic Profile Parameters in Holstein Dairy Cows

Yıl 2025, Cilt: 36 Sayı: 2, 107 - 114, 13.01.2026
https://doi.org/10.35864/evmd.1752756

Öz

Metabolic profile analyses are widely used to determine and standardize the nutritional and disease status of animals. Metabolic profile parameters do not have the same reference ranges in every case. In this study, it is aimed to evaluate the effect of parity and lactation period on metabolic parameters in Holstein dairy cows. In the study, a total of 60 dairy cows in the transition period (the last three weeks of pregnancy and the first three weeks of lactation) were used. Dairy cows were grouped according to their parity (1 (n:20), 2 (n:20), and 3 or more (n:20)), lactation period (early period: 0-60 days (n:20), mid period: 60-120 (n:20), late period: >120 (n:20)), and 305-day average milk yield (<35 L: low yield (n:20), >35 L: high yield (n:20)). Significant changes were detected in the levels of non-esterified fatty acid (NEFA) and β-hydroxybutyric acid (BHBA), which indicate energy status, alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), gama glutamil transferaz (GGT), and cholesterol, which indicate liver damage, and albumin levels among plasma proteins. It was concluded that considering these factors while evaluating the metabolic profile parameters in dairy cattle could be beneficial for better understanding the animals' condition and accurately interpreting the analyses.

Kaynakça

  • Andjelić B, Djoković R, Cincović M, Bogosavljević-Bošković S, Petrović M, Mladenović J, Čukić A. (2022) Relationships between milk and blood biochemical parameters and metabolic status in dairy cows during lactation. Metabolites. 12(8), 733.
  • Cavestany D, Blanc JE, Kulcsar M, Uriarte G, Chilibroste P, Meikle A, Krall E. (2005) Studies of the transition cow under a pasture‐based milk production system: metabolic profiles. J Vet Med. 52(1), 1-7.
  • Cozzi G, Ravarotto L, Gottardo F, Stefani AL, Contiero B, Moro L, Dalvit P. (2011) Reference values for blood parameters in Holstein dairy cows: Effects of parity, stage of lactation, and season of production. J Dairy Sci. 94(8), 3895-3901.
  • Gianesella M, Perillo L, Fiore E, Giudice E, Zumbo A, Morgante M, Piccione, G. (2018). Transition period in healthy and diseased dairy cows: evaluation of metabolic modifications. Large Anim Rev. 24: 107-111
  • Goff JP. (2008) The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J. 176(1), 50-57.
  • Gross JJ, Kessler EC, Albrecht C, Bruckmaier RM. (2015) Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage. PloS one. 10(6), e0121956.
  • Kuczyńska B, Puppel K, Gołębiewski M, Wiśniewski K, Przysucha T. (2020) Metabolic profile according to the parity and stage of lactation of high-performance Holstein-Friesian cows. Anim Biosci. 34(4), 575.
  • Lager K, Jordan E. (2012) The metabolic profile for the modern transition dairy cow. In Mid-South Ruminant Nutrition Conference (pp. 9-16), April 25–26, Texas-USA.
  • Lopez H, Caraviello DZ, Satter LD, Fricke PM, Wiltbank MC. (2005) Relationship between level of milk production and multiple ovulations in lactating dairy cows. J Dairy Sci. 88(8), 2783-2793.
  • Lee AJ, Twardock AR, Bubar RH, Hall JE, Davis CL. (1978) Blood metabolic profiles: their use and relation to nutritional status of dairy cows. J Dairy Sci. 61(11), 1652-1670.
  • Madreseh-Ghahfarokhi S, Dehghani-Samani A. (2020 Blood metabolic profile tests at dairy cattle farms as useful tools for animal health management. Bulg J Vet Med. 23(1), 1-20.
  • Morales-Piñeyrúa JT, Damián JP, Banchero G, Blache D, Sant'Anna AC. (2022) Metabolic profile and productivity of dairy Holstein cows milked by a pasture-based automatic milking system during early lactation: Effects of cow temperament and parity. Res Vet Sci. 147, 50-59.
  • Mukača A, Katica M. (2018) Effect of daily milk production levels on plasma calcium, phosphorus and magnesium concentrations in dairy cows. J İstanbul Vet Sci. 2(1), 23-29.
  • Nogalska A, Momot M, Sobczuk-Szul M, Pogorzelska-Przybyłek P, Nogalski Z. (2017) Calcium and magnesium content in the milk of high-yielding cows. J Elem. 22(3), 809-815.
  • Ospina PA, Nydam DV, Stokol T, Overton TR. (2010) Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J Dairy Sci. 93(2), 546-554.
  • Payne JM, Dew SM, Manston R, Faulks M. (1970) The use of a metabolic profile test in dairy herds, Vet Rec. 87, 150-158.
  • Puppel K, Kuczyńska B. (2016) Metabolic profiles of cow's blood; a review. J Sci Food Agric. 96(13), 4321-4328.
  • Sakowski T, Kuczyńska B, Puppel K, Metera E, Słoniewski K, Barszczewski J. (2012) Relationships between physiological indicators in blood, and their yield, as well as chemical composition of milk obtained from organic dairy cows. J Sci Food Agric. 92(14), 2905-2912.
  • Silva JH, Contreras LVQ, Ponath CF, Bondan C, Machado MC, González F. (2023) Concentrações sanguíneas de cálcio, fósforo e magnésio e diferença cátion-ânion da dieta de vacas leiteiras. Arq Bras Med Vet Zootec.75, 127-136.
  • Stengärde L, Tråvén M, Emanuelson U, Holtenius K, Hultgren J, Niskanen, R. (2008) Metabolic profiles in five high-producing Swedish dairy herds with a history of abomasal displacement and ketosis. Acta Vet Scand. 50, 1-11.
  • Stojević Z, Piršljin J, Milinković-Tur S, Zdelar-Tuk M, Beer Ljubić B. (2005) Activities of AST, ALT and GGT in clinically healthy dairy cows during lactation and in the dry period. Vet Arh. 75(1), 67-73.
  • Tsiamadis V, Banos G, Panousis N, Kritsepi-Konstantinou M, Arsenos G, Valergakis GE. (2016) Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows. J Dairy Sci. 99(7), 5535-5544.
  • Van Saun RJ. (2004) Metabolic profiling and health risk in transition cows. In American Association of Bovine Practitioners Conference Proceedings (pp. 212-213), September 23–25, Texas-USA.

Holştayn Sütçü Sığırlarda Parite, Laktasyon Dönemi ve Süt Verimi Metabolik Profil Parametreleri Üzerine Etkisi

Yıl 2025, Cilt: 36 Sayı: 2, 107 - 114, 13.01.2026
https://doi.org/10.35864/evmd.1752756

Öz

Metabolik profil analizleri hayvanların beslenme ve hastalık durumunun belirlenmesi ve standardize edilmesi için yaygın kullanılmaktadır. Metabolik profil parametreleri her durumda aynı referans aralıklarına sahip değildir. Bu çalışmada Holştayn ırkı sütçü sığırlarda parite ve laktasyon döneminin metabolik parametreler üzerindeki etkisinin değerlendirilmesi amaçlanmaktadır. Çalışmada geçiş döneminde (gebeliğinin son üç haftası ve laktasyonunun ilk üç haftası) bulunan toplam 60 adet süt ineği kullanıldı. Sütçü sığırlar kendi içerisinde paritesine (1 (n:20), 2 (n:20) ve 3 veya daha fazla (n:20)), laktasyon dönemine (erken dönem: 0-60 gün (n:20), orta dönem: 60-120 (n:20), geç dönem: >120 (n:20)) ve 305 günlük ortalama süt verimine (<35 L: düşük verim (n:20), >35 L: yüksek verim (n:20)) göre gruplandırıldı. Enerji durumunu gösteren belirteçlerden esterleşmemiş yağ asidi (NEFA) ve β-hidroksibutirik asit (BHBA), karaciğer hasarını gösteren belirteçlerden alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), gama glutamil transferaz (GGT) ve kolesterolün, plazma proteinlerinden ise albümin seviyesinde önemli değişiklikler tespit edildi. Sütçü sığırlarda metabolik profil parametreleri değerlendirilirken söz konusu faktörlerin dikkate alınmasının hayvanların durumunun daha iyi anlaşılması ve analizlerin doğru yorumlanması açısından faydalı olabileceği kanaatine varıldı.

Kaynakça

  • Andjelić B, Djoković R, Cincović M, Bogosavljević-Bošković S, Petrović M, Mladenović J, Čukić A. (2022) Relationships between milk and blood biochemical parameters and metabolic status in dairy cows during lactation. Metabolites. 12(8), 733.
  • Cavestany D, Blanc JE, Kulcsar M, Uriarte G, Chilibroste P, Meikle A, Krall E. (2005) Studies of the transition cow under a pasture‐based milk production system: metabolic profiles. J Vet Med. 52(1), 1-7.
  • Cozzi G, Ravarotto L, Gottardo F, Stefani AL, Contiero B, Moro L, Dalvit P. (2011) Reference values for blood parameters in Holstein dairy cows: Effects of parity, stage of lactation, and season of production. J Dairy Sci. 94(8), 3895-3901.
  • Gianesella M, Perillo L, Fiore E, Giudice E, Zumbo A, Morgante M, Piccione, G. (2018). Transition period in healthy and diseased dairy cows: evaluation of metabolic modifications. Large Anim Rev. 24: 107-111
  • Goff JP. (2008) The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J. 176(1), 50-57.
  • Gross JJ, Kessler EC, Albrecht C, Bruckmaier RM. (2015) Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage. PloS one. 10(6), e0121956.
  • Kuczyńska B, Puppel K, Gołębiewski M, Wiśniewski K, Przysucha T. (2020) Metabolic profile according to the parity and stage of lactation of high-performance Holstein-Friesian cows. Anim Biosci. 34(4), 575.
  • Lager K, Jordan E. (2012) The metabolic profile for the modern transition dairy cow. In Mid-South Ruminant Nutrition Conference (pp. 9-16), April 25–26, Texas-USA.
  • Lopez H, Caraviello DZ, Satter LD, Fricke PM, Wiltbank MC. (2005) Relationship between level of milk production and multiple ovulations in lactating dairy cows. J Dairy Sci. 88(8), 2783-2793.
  • Lee AJ, Twardock AR, Bubar RH, Hall JE, Davis CL. (1978) Blood metabolic profiles: their use and relation to nutritional status of dairy cows. J Dairy Sci. 61(11), 1652-1670.
  • Madreseh-Ghahfarokhi S, Dehghani-Samani A. (2020 Blood metabolic profile tests at dairy cattle farms as useful tools for animal health management. Bulg J Vet Med. 23(1), 1-20.
  • Morales-Piñeyrúa JT, Damián JP, Banchero G, Blache D, Sant'Anna AC. (2022) Metabolic profile and productivity of dairy Holstein cows milked by a pasture-based automatic milking system during early lactation: Effects of cow temperament and parity. Res Vet Sci. 147, 50-59.
  • Mukača A, Katica M. (2018) Effect of daily milk production levels on plasma calcium, phosphorus and magnesium concentrations in dairy cows. J İstanbul Vet Sci. 2(1), 23-29.
  • Nogalska A, Momot M, Sobczuk-Szul M, Pogorzelska-Przybyłek P, Nogalski Z. (2017) Calcium and magnesium content in the milk of high-yielding cows. J Elem. 22(3), 809-815.
  • Ospina PA, Nydam DV, Stokol T, Overton TR. (2010) Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J Dairy Sci. 93(2), 546-554.
  • Payne JM, Dew SM, Manston R, Faulks M. (1970) The use of a metabolic profile test in dairy herds, Vet Rec. 87, 150-158.
  • Puppel K, Kuczyńska B. (2016) Metabolic profiles of cow's blood; a review. J Sci Food Agric. 96(13), 4321-4328.
  • Sakowski T, Kuczyńska B, Puppel K, Metera E, Słoniewski K, Barszczewski J. (2012) Relationships between physiological indicators in blood, and their yield, as well as chemical composition of milk obtained from organic dairy cows. J Sci Food Agric. 92(14), 2905-2912.
  • Silva JH, Contreras LVQ, Ponath CF, Bondan C, Machado MC, González F. (2023) Concentrações sanguíneas de cálcio, fósforo e magnésio e diferença cátion-ânion da dieta de vacas leiteiras. Arq Bras Med Vet Zootec.75, 127-136.
  • Stengärde L, Tråvén M, Emanuelson U, Holtenius K, Hultgren J, Niskanen, R. (2008) Metabolic profiles in five high-producing Swedish dairy herds with a history of abomasal displacement and ketosis. Acta Vet Scand. 50, 1-11.
  • Stojević Z, Piršljin J, Milinković-Tur S, Zdelar-Tuk M, Beer Ljubić B. (2005) Activities of AST, ALT and GGT in clinically healthy dairy cows during lactation and in the dry period. Vet Arh. 75(1), 67-73.
  • Tsiamadis V, Banos G, Panousis N, Kritsepi-Konstantinou M, Arsenos G, Valergakis GE. (2016) Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows. J Dairy Sci. 99(7), 5535-5544.
  • Van Saun RJ. (2004) Metabolic profiling and health risk in transition cows. In American Association of Bovine Practitioners Conference Proceedings (pp. 212-213), September 23–25, Texas-USA.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Hekimlik
Bölüm Araştırma Makalesi
Yazarlar

Cennet Nur Ünal 0000-0002-8676-6490

Hakan Keçeci 0000-0001-8236-100X

Murat Uztimür 0000-0001-9294-1825

Gönderilme Tarihi 29 Temmuz 2025
Kabul Tarihi 7 Kasım 2025
Yayımlanma Tarihi 13 Ocak 2026
Yayımlandığı Sayı Yıl 2025 Cilt: 36 Sayı: 2

Kaynak Göster

APA Ünal, C. N., Keçeci, H., & Uztimür, M. (2026). The Effect of Parity, Lactation Period, and Milk Yield on Metabolic Profile Parameters in Holstein Dairy Cows. Etlik Veteriner Mikrobiyoloji Dergisi, 36(2), 107-114. https://doi.org/10.35864/evmd.1752756


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