The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration

Altuğ Küçükgül

doi:10.35864/evmd.514517

The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration

Öz

Oxidative stress has been known to play an important role in the pathogenesis of various neurodegenerative diseases. Dietary polyphenols and other natural antioxidants are the most popular compounds in clinical testing for the elimination of neurodegeneration. It has been demonstrated in recent studies that fruit of Zizyphus jujuba possesses several vital biological activities. This study intends to evaluate antioxidant activity of Zizyphus jujuba on human glioblastoma cells. Cell survival was quantified by colorimetric viability assay with dose response. Cells were pretreated with 100 μM Ziziphus jujuba essential oil for 1h, then 100 μM H2O2 was added to the cells for 12 hours. After that, the cell medium were taken after treatment period and replaced with fresh medium. Total oxidant capacity (TOS) and total antioxidant capacity (TAS) levels were estimated using specific colorimetric methods. Oxidative stress index (OSI) was calculated from the ratio of TOS and TAS values. Many researches have been reported that the essential oil from seeds helps to prevent the oxidative stress induced neuronal diseases. The antioxidant potential of Ziziphus jujuba may be attributed to the presence of flavonoids and the other constituents present therein. Our data suggested that Ziziphus jujuba is effective in preventing H2O2-induced oxidative stress.

Anahtar Kelimeler

Oxidative stress,Neurodegeneration,Ziziphus jujuba

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

Altuğ Küçükgül ^* Bu kişi benim

Yayımlanma Tarihi

15 Aralık 2016

Gönderilme Tarihi

18 Ekim 2016

Kabul Tarihi

15 Kasım 2016

Yayımlandığı Sayı

Yıl 2016 Cilt: 27 Sayı: 2

DOI

https://doi.org/10.35864/evmd.514517

IZ

https://izlik.org/JA56UN49NN

Kaynak Göster

RIS / Bibtex

APA

Küçükgül, A. (2016). The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration. Etlik Veteriner Mikrobiyoloji Dergisi, 27(2), 108-112. https://doi.org/10.35864/evmd.514517

AMA

1.Küçükgül A. The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration. Etlik Vet. Mik. Derg. 2016;27(2):108-112. doi:10.35864/evmd.514517

Chicago

Küçükgül, Altuğ. 2016. “The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration”. Etlik Veteriner Mikrobiyoloji Dergisi 27 (2): 108-12. https://doi.org/10.35864/evmd.514517.

EndNote

Küçükgül A (01 Aralık 2016) The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration. Etlik Veteriner Mikrobiyoloji Dergisi 27 2 108–112.

IEEE

[1]A. Küçükgül, “The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration”, Etlik Vet. Mik. Derg., c. 27, sy 2, ss. 108–112, Ara. 2016, doi: 10.35864/evmd.514517.

ISNAD

Küçükgül, Altuğ. “The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration”. Etlik Veteriner Mikrobiyoloji Dergisi 27/2 (01 Aralık 2016): 108-112. https://doi.org/10.35864/evmd.514517.

JAMA

1.Küçükgül A. The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration. Etlik Vet. Mik. Derg. 2016;27:108–112.

MLA

Küçükgül, Altuğ. “The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration”. Etlik Veteriner Mikrobiyoloji Dergisi, c. 27, sy 2, Aralık 2016, ss. 108-12, doi:10.35864/evmd.514517.

Vancouver

1.Altuğ Küçükgül. The Antioxidant Effects of Ziziphus Jujuba on Neurodegeneration. Etlik Vet. Mik. Derg. 01 Aralık 2016;27(2):108-12. doi:10.35864/evmd.514517

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