Prions and related diseases

Öz

Prionlar ve Yaptıkları Hastalıklar

Öz

"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen, temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundan oluşan küçük, proteinden zengin, infeksiyöz partiküller" olarak tanımlanabilirler (42). Genetik bilginin nükleik asitlerden proteinlere dönüşümü , moleküler biyolojinin temel doktrini olarak kabul edilmektedir. Insanlarda ve hayvanlarda olduğu gibi bakterilerde de proteinlerin ve enzimierin yapısını belirleyen, böylece şekil ve gelişmeyi tayin eden DNA'dır. Hücre dışında bağımsız olarak üreyemeyen viruslar bile, kimliklerini bir DNA veya RNA molekülünden alırlar. Bazı bitki hastalıklarını nakleden viroid'ler de ANA'dan meydana gelmişlerdir (39) . Viroid'in nükleik asidi, proteini kodlamaz ancak progeny moleküller için bir kalıp olarak hizmet eder (12). Prion olarak tanımlanan infeksiyöz etkenin ortaya çıkması ise her organizmanın kendi kimliğini belirleyen nükleik asitleri taşıdığı kuralını geçersiz kılmıştır (39).

Anahtar Kelimeler

• Prionlar
• 1994
• Etlik Veteriner Mikrobiyoloji Dergisi

Kaynakça

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