Kuzuların Deneysel "Cerebral Coenurosis"inde Albendazol ve Praziquantel'in Kistler Üzerine Etkisinin Patolojik Olarak İncelenmesi

Öz

Kuzularda deneysel olarak oluştunılmuş cerebral coenurosis olgularında, albendazol ve praziquantel ' in kistler üzerine etkileri, ınakroskopik ve mikroskobik bulguları yla patolojik yönden incelendi. Bu amaçla, 5500 Taenia multiceps yumurtası ile oral enfekte edilmiş ve 5 ' ine albendazol ve 5 ' ine de praziquantel uygulanmış toplam 10 adet 3-4 aylık Akkaraman kuzu 'ya ait beyinler kullanıldı . Kontrol grubu olarak kullanılan 5 kuzudaki kistler ile albendazol ve praziquantel sağaltını gnıbundaki kİstiere ait yapılarla protoskolekslerin nekroze olması , kalsifıkasyonu ve ayrıca konakçı reaksiyonunun gerilemesi şeklinde etkili oldu . Patolojik bulgular açısından, her iki ilacın etkisinde belirgin bir fark gözlenmedi. Ancak dejenere olan kist sayısının daha çok ve canlı protoskolekslerin saptanmamasıyla praziquantel ' in albendazol 'e göre daha etkili olduğu gözönüne alınabilir.

Anahtar Kelimeler

• Cerebral Coenurosis
• Kuzu
• Albendazol
• Praziquantel
• Kist
• Patolojik İnceleme
• 1996
• Yılmaz AYDIN
• Gülay BIYIKOĞLU
• Etlik Veteriner Mikrobiyoloji Dergisi

A Pathological Study Of Effects Of Praziquantel and Albendazole on Cerebral Coenurosis in Experimentally İnfected Lambs

Öz

The effects of praziquantel and albendazole on cerebral cocnurosis in experimentally infected lambs was examined pathologically. For this purposc, 15 Akkaraman Lambs aged 3-4 months were used. All lambs were infected orally with suspensions of 5500 Taenia multiceps eggs in physiologycal saline. They were divided into 3 groups consisting of 5 lambs each. Animals in groups one and two included individuals which were subjected to albendazole and praziquantel treatınent.respectively. The third group was kept as control. The brain of each lamb was removed soon after death and examinecl grossly and histopathologically for coenuri. The location of coenuri and associated lesioııs in the brain of control and treatment groups were deseribed in detail. Both albendazole and praziquantel was found to be affected against coenuri such as shrunken and degeneration of cysts, necrosis and calcifıcation in interi or parts of cysts, regression of surraunding host reaction. lt was not observed prominent differences in effects of these two dnıgs. The number of the degenerated cysts was higher and the alive protoscoleces were not found in praziquantel group. Therefore, it could be considered that praziquantel was more effective than albendazole.

Kaynakça

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