Comparative Studies on Vaccination of dogs With Avianized Kelev Virus and unactivated Semple Vaccine

Yıl 1968, Cilt: 3 Sayı: 5-6, 10 - 22, 01.12.1968

Mükerrem Güley Mehmet Toker

Öz

Avianized Kelev and inactivated Semple rables Vaccines comparativly
tested on 20 dogs, older than six months: In this experiment 10 dogs were vaccinated with Kelev vaccine 2.5 ml intramuscularly
Another 10 dogs were inoculated twice, at ten days interval
with a dose of 10 ml inactiveted Semple vaccine. A serum- neutralization
test was carried out on these dogs before and at 1 st, 3 rd,
6 the and 12 th months after vaccination. Only the Nr. 1 dog serum
had prevaccination antibodies.
Revaccination carried out on 5 dogs from each group at the
end of sixth month of the first vaccaination.
(Table: I and II) showing the results of serum neutralization
test.
The neutralizing antibodies of Kelev vaccine established in 2
dogs in the first month, in S dogs in the third month, and in 9
dogs at the end of sixth months of the vaccination. The revaccinated
5 dogs showed some rising titers of antibodies. After twelve
months, all the sera contained a certain amount of antibidies excpt Nr. 16.
We obtained the following results with the Semple vaccine
test: Antibodies demonstrated in 3 dogs after one month, in 3 dogs
after three months and in 4 dogs after six months of vaccination.
Three out of 5 revaccinated animals gave the high antibody titers.
With- this test only 4 revaccinated dogs gave antibodies at the end
of twelve months.
It was understood that one dose of Kelev vaccine produce antibodies
for one year.

Avianize Kelev Kuduz Aşısı ile Semple Tipi Kuduz Aşısının Köpeklerde Meydana Getirdiği Muafiyetin Serolajik Olarak Tesbiti

Öz

Altı aylıktan büyük 20 köpek üzerinde avianize Kelev ve inaktiv
Semple aşıları mukayeseli olarak denendi. 10 köpeğe adele içi 2,5
ml Kelev aşısı, 10 köpeğe deri altı yoluyla 10 gün ara ile iki defada
10'ar ml Semple aşısı verildi. Bu köpeklerde aşılamadan evvel
ve · aşılandıktan sonra 1 ci. 3 üncü, 6 ncı ve 12 nci aylar kan a'lınarak
serum nötralizasyon testi yapıldı. Aşılamadan önce alınan serumlardan sadece 1 numaralı köpekte antikor tesbit edildi. Her iki gruptan beşer adet köpek aşılamanın altıncı ayında birer doz aşı ile revaksine edildi.
Serum Nötralizasyon testinin sonuçları (Cetvel: I ve II) de görülmektedir.
Kelev aşısında, nötralizan antikor aşılamanın birinci ayında
iki, üçüncü ayında beş, altıncı ayında dokuz köpekte tesbit edildi.
Revaksineden sonra beş köpeğin antikor titrelerinde biraz yükselme,
onikinci ay alınan serumlarda ise 16 numaralı köpek müstesna
diğer dokuz köpekte antikor mevcut olduğu görüldü.
Semple aşısında, aşılamanın birinci ayında üç, üçüncü ayında
üç, altıncı ayında ise dört köpekte antikor tesbit edilmiş, altıncı
ayda epruve edilen beş köpekten bilhassa üç adedinü1 kanındaki
antikor titresi çok yükselmiş, onikinci ay serumlarında sadece
revaksine edilenlerden dört adedinde antikor tesbit edilebilmiş,
diğerlerinde kayda değer birşey bulunamamıştır.
Bu deneme göstermiştir ki Kelev aşısının bir dozu köpeklerde,
bir sene devam eden antikor tevlit etmektedir.

Anahtar Kelimeler

Avianize Kelev Kuduz Aşısı, Kuduz, Avianize Kelev, Semple, Köpek

Kaynakça

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