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Bovine Spongiform Encephalopathy ve Sığırların Diğer Spongiform Encephalopathy'leri

Yıl 1992, Cilt: 7 Sayı: 3, 13 - 24, 01.12.1992

Öz

Spongifom terimi patoloji literatüründe esası intramyelinik ödem olan
beyaz madde mikrokavitasyonunu ifade etmek için kullanılır. Bir çok kimyasal,
toksik, metabolik ve kalıtsal bozuklukların nöyropatolojik temel bir
özelliğidir(28). .
Bovine spongifom encephalopathy ise ilk defa 1986 yılında Ingiltere'de
farklı coğrafik yerleşimlerdeki süt ineklerinde bildirilmiştir.Hastalık ergin
sığırların yavaş, progresif seyirli nöyrolojik bir hastalığıdır.Histolojik bakıda
beyin sterninin gri maddesinde bilateral, simetrik dejeneratif değişiklikler ve
özellikle gri madde nöyropilinde vakuolasyon dikkati çeker (30). BSE terimi
bir yandan morfolojik olarak nöyron ve nöyropildeki vakuolar değişiklikleri
açıklar diğer yandan da bu değişikliklerin bilinmeyen enfeksiyöz ajanlar
tarafından oluşturulan diğer spongifom1 ensefalopatilere olan yakın benzerliğini
vurgular.
Spongifom ensefalopatilerden sorumlu tutulan bilinmeyen aktarılabilir
ajanlar birçok biyolojik fiziksel ve kimyasal özelliklere sahiptir. Bu ajanlar formaldehide,
B-propiolaktona, EDTA ( etilen-diamin-tetra asetat)'ya,proteazlara
(tripsin, pepsin), nukleazlara (ribonukleazlar A ve III, deoksiribonukleaz I),
ısıya (8°C'ye kadar; 10° C'da tam olmayarak inaktive olurlar),ultraviyole
ışınlarına (2540 A'de), iyonize ışınlara(röntgen ışınları)ve ultrasonik enerjiye
dirençlidirler.Elektron mikroskopide tanımlanabilir viryonlar olarak
görülemezler.Enfekte doku kültürlerinde in vitro sitopatik etki gösterilmemiştir
.Ajanlara karşı interferon yapılmaz ve interferona duyarlılıkları yoktur.
Ajanlann virusların interferon yapımını engellediği de saptanmamıştır.

Kaynakça

  • Barlow, R. M. And Middleton, D.J. : 1990. Dietary transmission of bovine spongiform encephalopathy to mice. Vet. Rec., 126: 111-112
  • Bassett, H.F., and Sheridan, C.: 1989. Case of BSE in the Irish Republic. Vet.Rec., 124 (6) : 151
  • Bolton, D.C.: McKinley, M.P. and Prusiner. S.B. 1984.: Molecular characteristics of the major scrapie prion protein. Biochemistry, 23: 5898 - 5906
  • Bolton, D.C., Meyer. R.K. and Prusiner, S.B.: 1985. Scrapie Prp 27-30 is a sialoglycoprotein. J. Virol., 53 (2) : 596-606
  • Brown, P., Coker-Vann, M.: Pomeroy, K., Franko, M., Asher, D.M., Gibbs, C.J. and Gadjusek, D.C. : 1986. Diagnosis of Crcutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue N.Engl. J.Med., 314 (9): 547-551
  • Carp, R.I. Merz, P.A., Kascak, R.J., Merz, G.S. and Wi s niev~ki, H.M.: 1985. Nature of the scr:ıpie agent: Current status of facts and hypotheses. J. Gen. Virol., 66: ı357- . 1368
  • Cranwell, M.P., Hannock, R.D., Hindson. J.R., Hall, S.A., Daniel, N.J., Hopkins, A.R., Wonnacot, B., Vivian, M. and Hunt, P. : ı988. Bovine spongiform encephalopathy, Vet. Rec., ı22 (8) : ı90
  • Dawson, M., Wells, G.A.H. and Parker, B.N.J.: 1990. Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle. Vet. Rec. 126: 112-ıB
  • Fraser, H., McConnel, I., Wells, G.A.H. and Dawson, M.: 1988 Transmission of bovine spongiform encephalopathy to ınice. Vet. Rec., 123: 472
  • Gibson, P.H., Somerville, R.A., Fraser, H., Foster, J.D. and Kimberlin, R.H.: ı987 . Scrapie associated fibrils in the diagnosis of scrapie in sheep, Vet, Rec., 120; ı25-127
  • Harper, P.A.W., Healy, P.J. and Dennis, J.A.: 1986. Maple syrup urine disease as a ca use of spongiform encephalopathy in calves. Vet. Rec., 1 ı 9: 62-65
  • Harper, P.A.W., Heally, P.J. and Dennis, J.A. ı 986. Inherited congenital m yoel an us of polled Hereford ca!ves so-called neuraxial oedema: a clinical, pathological and biochemical study. Vet. Rec., 119: 59-62
  • Harper, P.A.W., Hartley, W.I., Coverdale, O.R. and Gill, J.M.: 1989. Multifokal symmetrical encephalopathy in Simmental calves. Vet. Rec., 124: ı22-ı23
  • Hope, J., Reeke, L.J.D., Hunter, N., Multhaup, G., Beyreuther. K., White, H., Scott, A.C., Stack, M.J., Dawson, M. and Wells, G.A.H.: 1988. Fibrils from brains of cows with new cattle disease contain scrapie associated protein. Nature, 336: 390-392
  • Hulland, T.J.: 1957. Cerebellar ataxia in calves. Can. J. Comp. Med. 21 (3): 72-76
  • Jolly, R.D.: 1974. Congenital brain oedeına of Hereford calves. J.Pathol., 114: 119- 204
  • Jones, T.C. and Hunt, R.D.: 1983. Veterinary Pathology. Fifth edition. Philadelplıia , Lea and Febiger, U.S.A. p. 500-505
  • Merz, P.A., Somerville, R.A. and Wisniewski, H.M.: 1983. Scrapie-associated fibrils in Creutsfeldt-Jakob disease. Nature, 306: 474-476 .
  • Morgan, K.L.: 1988. Bovine spongiform encephalopathy: time to take scrapie seriously. Vet. Rec., 122 (18): 445-446
  • Munday, B.L., Mason, R.W. and Hartley, W.J. : 1976. Encephalopathies in cattle in Tasmania. Aust. Vet. J., 52: 92-96
  • Palmer, A.C., Jackson, P.G.G. and Hudson, W. E.: 1988. Encephalopathy in calves. Vet. Rec., 123: 114
  • Pattison, I.H.: 1991. Origins of BSE. Vet. Rec., 128 (ll): 262 - 262
  • Prusiner, S.B.: 1984. Prions. Scientific American, 251: 48-57
  • Saunders, L.Z., Sweet, J.D., Martyı , S.M., Fox, F.H. and Fincher, M.G.: 1952. Hereditary congenital ataxia in Jersey calves. Comeli Vet., 42: 559-591
  • Scott, A.C., Done, S.H., Venables, C. and Dawson, M. 1987. Detection of scrapieassociated fibrils as an aid to the diagnosis of natural sheep scrapie.Vet. Rec., 120: 280- 281
  • Scott, P. R. Aldridge, B.M., Holmes, L.A., Milne, E.M. and Collins, D. M. :1988. Bovine spongiform encephalopathy in an adult British Friesian cow. Vet. Rec., 123: 373-374
  • Scott, P.R., Aldridge, B.M., Clarke, M. and Will, R.: 1989. Bovine spongiform encephalopathy ina cow in the United Kingdom. J.A.V.M.A., 195 (12): 1745- 1747
  • Jubb, K.V.F., Kenned, P.C. and Palmer, N.: 1985. Pathology of domestic animals. 3. rd edition. Vol. 1. Orlando, Acadeinic Press, p. 227-305
  • Taylor, D.M.: 1989. Scrapie agent decontamination: implications for bovine spongiform encephalopathy. Vet. Rec., 24: 291-292
  • Wells, G.A.H., Scott, A.C., Johnson, C.T., Gunning, R.F., Hannock, R.D., Jeffrey, M., Dawson, M. and Bradley, R.: 1987. A nowel progressive spongiform encephalopathy in cattle. Vet. Rec., 121: 419-420
  • Wilesmith, J.W., Wells, G.A.H., Cranwell, M.P. and Ryan, J.B.M.: 1988. Bovine spongiform encephalopathy : Epidemiological studies. Vet. Rec., 123: 638-644
  • Wilesmith, J.W., Ryan, J.I;l .M. and Atkinson, M.J.: 1991. Bovine spongiform encephalopathy: Epidemiological studies on the origin. Vet. Rec., 128 (9): 199-203
  • Winter, M.H., Aldridge, B. M., Scott, P. R. and Clarke, M.: 1989. Occurrence of 14· cases of bovine spongiforrn encephalopathy ina closed dairy herd. Br. Vet. J., 145: 191- 194

«Bovine spongioform encephalopathy and other bovine encephalopathies»

Yıl 1992, Cilt: 7 Sayı: 3, 13 - 24, 01.12.1992

Öz

Kaynakça

  • Barlow, R. M. And Middleton, D.J. : 1990. Dietary transmission of bovine spongiform encephalopathy to mice. Vet. Rec., 126: 111-112
  • Bassett, H.F., and Sheridan, C.: 1989. Case of BSE in the Irish Republic. Vet.Rec., 124 (6) : 151
  • Bolton, D.C.: McKinley, M.P. and Prusiner. S.B. 1984.: Molecular characteristics of the major scrapie prion protein. Biochemistry, 23: 5898 - 5906
  • Bolton, D.C., Meyer. R.K. and Prusiner, S.B.: 1985. Scrapie Prp 27-30 is a sialoglycoprotein. J. Virol., 53 (2) : 596-606
  • Brown, P., Coker-Vann, M.: Pomeroy, K., Franko, M., Asher, D.M., Gibbs, C.J. and Gadjusek, D.C. : 1986. Diagnosis of Crcutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue N.Engl. J.Med., 314 (9): 547-551
  • Carp, R.I. Merz, P.A., Kascak, R.J., Merz, G.S. and Wi s niev~ki, H.M.: 1985. Nature of the scr:ıpie agent: Current status of facts and hypotheses. J. Gen. Virol., 66: ı357- . 1368
  • Cranwell, M.P., Hannock, R.D., Hindson. J.R., Hall, S.A., Daniel, N.J., Hopkins, A.R., Wonnacot, B., Vivian, M. and Hunt, P. : ı988. Bovine spongiform encephalopathy, Vet. Rec., ı22 (8) : ı90
  • Dawson, M., Wells, G.A.H. and Parker, B.N.J.: 1990. Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle. Vet. Rec. 126: 112-ıB
  • Fraser, H., McConnel, I., Wells, G.A.H. and Dawson, M.: 1988 Transmission of bovine spongiform encephalopathy to ınice. Vet. Rec., 123: 472
  • Gibson, P.H., Somerville, R.A., Fraser, H., Foster, J.D. and Kimberlin, R.H.: ı987 . Scrapie associated fibrils in the diagnosis of scrapie in sheep, Vet, Rec., 120; ı25-127
  • Harper, P.A.W., Healy, P.J. and Dennis, J.A.: 1986. Maple syrup urine disease as a ca use of spongiform encephalopathy in calves. Vet. Rec., 1 ı 9: 62-65
  • Harper, P.A.W., Heally, P.J. and Dennis, J.A. ı 986. Inherited congenital m yoel an us of polled Hereford ca!ves so-called neuraxial oedema: a clinical, pathological and biochemical study. Vet. Rec., 119: 59-62
  • Harper, P.A.W., Hartley, W.I., Coverdale, O.R. and Gill, J.M.: 1989. Multifokal symmetrical encephalopathy in Simmental calves. Vet. Rec., 124: ı22-ı23
  • Hope, J., Reeke, L.J.D., Hunter, N., Multhaup, G., Beyreuther. K., White, H., Scott, A.C., Stack, M.J., Dawson, M. and Wells, G.A.H.: 1988. Fibrils from brains of cows with new cattle disease contain scrapie associated protein. Nature, 336: 390-392
  • Hulland, T.J.: 1957. Cerebellar ataxia in calves. Can. J. Comp. Med. 21 (3): 72-76
  • Jolly, R.D.: 1974. Congenital brain oedeına of Hereford calves. J.Pathol., 114: 119- 204
  • Jones, T.C. and Hunt, R.D.: 1983. Veterinary Pathology. Fifth edition. Philadelplıia , Lea and Febiger, U.S.A. p. 500-505
  • Merz, P.A., Somerville, R.A. and Wisniewski, H.M.: 1983. Scrapie-associated fibrils in Creutsfeldt-Jakob disease. Nature, 306: 474-476 .
  • Morgan, K.L.: 1988. Bovine spongiform encephalopathy: time to take scrapie seriously. Vet. Rec., 122 (18): 445-446
  • Munday, B.L., Mason, R.W. and Hartley, W.J. : 1976. Encephalopathies in cattle in Tasmania. Aust. Vet. J., 52: 92-96
  • Palmer, A.C., Jackson, P.G.G. and Hudson, W. E.: 1988. Encephalopathy in calves. Vet. Rec., 123: 114
  • Pattison, I.H.: 1991. Origins of BSE. Vet. Rec., 128 (ll): 262 - 262
  • Prusiner, S.B.: 1984. Prions. Scientific American, 251: 48-57
  • Saunders, L.Z., Sweet, J.D., Martyı , S.M., Fox, F.H. and Fincher, M.G.: 1952. Hereditary congenital ataxia in Jersey calves. Comeli Vet., 42: 559-591
  • Scott, A.C., Done, S.H., Venables, C. and Dawson, M. 1987. Detection of scrapieassociated fibrils as an aid to the diagnosis of natural sheep scrapie.Vet. Rec., 120: 280- 281
  • Scott, P. R. Aldridge, B.M., Holmes, L.A., Milne, E.M. and Collins, D. M. :1988. Bovine spongiform encephalopathy in an adult British Friesian cow. Vet. Rec., 123: 373-374
  • Scott, P.R., Aldridge, B.M., Clarke, M. and Will, R.: 1989. Bovine spongiform encephalopathy ina cow in the United Kingdom. J.A.V.M.A., 195 (12): 1745- 1747
  • Jubb, K.V.F., Kenned, P.C. and Palmer, N.: 1985. Pathology of domestic animals. 3. rd edition. Vol. 1. Orlando, Acadeinic Press, p. 227-305
  • Taylor, D.M.: 1989. Scrapie agent decontamination: implications for bovine spongiform encephalopathy. Vet. Rec., 24: 291-292
  • Wells, G.A.H., Scott, A.C., Johnson, C.T., Gunning, R.F., Hannock, R.D., Jeffrey, M., Dawson, M. and Bradley, R.: 1987. A nowel progressive spongiform encephalopathy in cattle. Vet. Rec., 121: 419-420
  • Wilesmith, J.W., Wells, G.A.H., Cranwell, M.P. and Ryan, J.B.M.: 1988. Bovine spongiform encephalopathy : Epidemiological studies. Vet. Rec., 123: 638-644
  • Wilesmith, J.W., Ryan, J.I;l .M. and Atkinson, M.J.: 1991. Bovine spongiform encephalopathy: Epidemiological studies on the origin. Vet. Rec., 128 (9): 199-203
  • Winter, M.H., Aldridge, B. M., Scott, P. R. and Clarke, M.: 1989. Occurrence of 14· cases of bovine spongiforrn encephalopathy ina closed dairy herd. Br. Vet. J., 145: 191- 194
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Öznur Yazıcıoğlu Bu kişi benim

Yayımlanma Tarihi 1 Aralık 1992
Gönderilme Tarihi 1 Aralık 1992
Yayımlandığı Sayı Yıl 1992 Cilt: 7 Sayı: 3

Kaynak Göster

APA Yazıcıoğlu, Ö. (1992). Bovine Spongiform Encephalopathy ve Sığırların Diğer Spongiform Encephalopathy’leri. Etlik Veteriner Mikrobiyoloji Dergisi, 7(3), 13-24.


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