«Bovine viral diarrhea-Mucosal disease (BVD/MD) »

Yıl 1992, Cilt: 7 Sayı: 3, 65 - 76, 01.12.1992

Fatma Uyanık

Öz

Bovine Viral Diarrhea / Mucosal Disease ( BVD/MD)

Öz

Bovine viral diarrhea/mucosal disease (BVD/MD) infeksiyonu,bovine viral
diarrhea virusu (BVDV) tarafından oluşturulan ve sığırlarda görülen bir hastalıktır.
Bu hastalığı,ilk kez 1946 yılında Olafson ve arkadaşları,ABD'de
akut,genellikle öldürücü,sindirim sistemi mukozasında ülserler ve diyare ile
seyreden sığır vebasına benzer tablo gösteren bir sürüde saptamışlar ve" Virusi
Diarrhea " adını veımişlerdir. Ramsey ve Chivers de 1953 yılında benzer belirtiler
gösteren bir hastalığı saptamışlar ve mukozal lezyonların çok şiddetli
olması nedeni ile bu hastalığı "Mucosal Disease" olarak adlandırmışlardır. Bir
süre bunlar iki ayrı hastalık olarak düşünülmüşse de daha sonraları bu iki
sendromdan da aynı virusun sorumlu olduğuna karar verilmiş ve hastalığa
"Bovine Viral Diarrhea/Mucosal Disease" adı verilmiştir (2,12,18).
Bugün, BVD ve MD'in, aynı etyolojik ajan tarafından oluşturulduğu ve
ayrı klinik tablolar gösterdiği kabul edilmektedir. Deneyesel olarak sitepatojen
olmayan (CPE oluşturmayan) BVD virusu ile infeksiyondan sonra sitepatojen
(CPE oluşturan) bir BVD virusu ile infekte edilen sığırlarda mucosal disease
şekillenmektedir. Mukozal diseaese'in persiste infeksiyon oluşturan CPE
oluşturmayan BVD virusunun, CPE oluşturan BVD virusuna mutasyonu ile
de şekillenebileceği bildirilmiştir (2,7).

Anahtar Kelimeler

Bovine Viral Diarrhea, Bovine, Viral Diarrhea, Mucosal Disease, BVD, MD, Fatma UYANIK, 1992, Etlik Veteriner Mikrobiyoloji Dergisi

Kaynakça

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