Prions and related diseases

Yıl 1994, Cilt: 7 Sayı: 5, 203 - 222, 01.12.1994

Vildan Özdemir

Öz

Prionlar ve Yaptıkları Hastalıklar

Öz

"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen,
temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundan
oluşan küçük, proteinden zengin, infeksiyöz partiküller" olarak
tanımlanabilirler (42).
Genetik bilginin nükleik asitlerden proteinlere dönüşümü , moleküler
biyolojinin temel doktrini olarak kabul edilmektedir. Insanlarda ve hayvanlarda
olduğu gibi bakterilerde de proteinlerin ve enzimierin yapısını belirleyen,
böylece şekil ve gelişmeyi tayin eden DNA'dır. Hücre dışında bağımsız
olarak üreyemeyen viruslar bile, kimliklerini bir DNA veya RNA molekülünden
alırlar. Bazı bitki hastalıklarını nakleden viroid'ler de ANA'dan
meydana gelmişlerdir (39) . Viroid'in nükleik asidi, proteini kodlamaz ancak
progeny moleküller için bir kalıp olarak hizmet eder (12). Prion olarak tanımlanan
infeksiyöz etkenin ortaya çıkması ise her organizmanın kendi
kimliğini belirleyen nükleik asitleri taşıdığı kuralını geçersiz kılmıştır (39).

Anahtar Kelimeler

Prionlar, 1994, Etlik Veteriner Mikrobiyoloji Dergisi

Kaynakça

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