Araştırma Makalesi
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Zoonotik ajan: Rodentlerde Bartonella spp

Yıl 2021, Cilt: 32 Sayı: 1, 63 - 68, 30.06.2021
https://doi.org/10.35864/evmd.905289

Öz

Zoonotik ajanların konakçı türlerini belirlemek, ortaya çıkan bulaşıcı hastalıkları kontrol etmenin anahtarlarından biridir. Dünya çapında yapılan çalışmalar, kemirgenlerin bakteriyel ve viral bulaşıcı ajanların eko-epidemiyolojisinde önemli rol oynadığı göstermiştir. Aynı zamanda, kemirgenler, zoonoz etkenlerden olan Bartonella spp etkeninin doğal rezervuarlarıdır. Özellikle, konakçı ve rezervuar görevi üstlenen rodentlerlerde, Bartonella spp gibi göz ardı edilebilen patojenlerin izlenmesi ve epidemiyolojik çalışmalar yapılması önemlidir. Potansiyel halk sağlığı riskli bir etken olmasına ragmen, Bartonella spp etkeninin tespiti üzerine ülkemizde sınırlı sayıda araştırma yapılmıştır. Çalışmamızda, Türkiye’nin beş farklı yerleşim biriminden toplanan 41 rodent örneğinde real time PCR yöntemi ile Bartonella spp. varlığı araştırıldı. Real time PCR ile çalışılan rodent dalak örneklerinden 6’sı (% 14.63) Bartonella spp. yönünden pozitif bulundu. Çalışmamızın sonucunda, yabani kemirgen türlerinin, hastalığın oluşumunda olası rezervuar olarak kabul edilebileceği ve bu alanda daha fazla çalışmaya ihtiyaç olduğu kanaatine varıldı.

Kaynakça

  • Abbot P, Aviles AE, Eller L, Durden LA (2007). Mixed infections, cryptic diversity, and vector-borne pathogens: Evidence from Polygenis fleas and Bartonella species. Appl Environ Microbiol, 73:6045–6052.
  • Alexsandra Rodrigues de Mendonça Favachoa Marcelle Novaes Andradea Renata Carvalhode Oliveiraa Cibele Rodrigues Bonvicinob Paulo Sergio D'Andrea Elba Regina Sampaiode Lemosa (2015). Zoonotic Bartonella species in wild rodents in the state of Mato Grosso do Sul, Brazil Microbes and Infection, 17, 11–12, 889-892.
  • Avidor B, Graidy M, Efrat G, Leibowitz C, Shapira G, Schattner A, Zimhony O, Giladi M Bartonella infections. Koehler JE (1996). Adv Pediatr Infect Dis, 11,1-27.
  • Bermond D, Boulouis HJ, Heller R, Laere Guy Van, Monteil Henri, B Chomel Bruno, Sander Anna, Dehio Christoph, Piémont Yves (2002) Bartonella bovis sp. nov. and Bartonella capreoli sp. nov., isolated from European ruminants. Int J Syst Evol Microbiol, 52(Pt 2):383-390. doi: 10.1099/00207713-52-2-383.
  • Birtles J Richard J (2005). Bartonellae as elegant hemotropic parasites. Ann N Y Acad Sci, 1063:270-9. doi: 10.1196/annals.1355.044.
  • Breitschwerdt EB, Kordick DL (2000). Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. Clin Microbiol Rev, 13(3), 428-38.
  • Brinkerhoff RJ (2008). Mammal and Flea Occurrence in Association with Black-Tailed Prairie Dog (Cynomys Ludovicianus) Colonies: Implications for Interspecific Plague Transmission. Ph.D. Dissertation University of Colorado, Boulder, Colorado, USA.
  • Buffet JP, Kosoy M, Vayssier TM (2013). Natural history of Bartonella-infecting rodents in light of new knowledge on genomics, diversity and evolution. Future Microbiol, 8:1117–1128.
  • Chang CC, Chomel BB, Kasten RW, Heller RM, Kocan KM, Ueno H, Yamamoto K, Bleich VC, Pierce BM, Gonzales BJ, Swift PK, Boyce WM, Jang SS, Boulouis HJ, Piémont Y (2000). Bartonella spp. isolated from wild and domestic ruminants in North America. Emerg Infect Dis, 6(3):306-11.
  • Chomel B B, Abbott RC, Kasten RW, Hawkins F KA, Kass PH, Glaser CA, Pedersen NC, Koehler CE (1995). Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. Journal of Clinical Microbiology, 33 (9), 2445-2450.
  • Chomel BB, Kasten RW, Floyd-Hawkins K, Chi B, Yamamoto K, Roberts-Wilson J, Gurfield AN, Abbott RC, Pedersen NC, Koehler JE (1996). Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol, 34(8), 1952-6.
  • Chomel BB, R C Abbott, R W Kasten, K A Floyd-Hawkins, P H Kass, C A Glaser, N C Pedersen, J E Koehler 1995J Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. Clin Microbiol. Sep;33(9):2445-50. doi: 10.1128/JCM.33.9.2445-2450.1995.
  • Çelebi B (2008). Bartonella henselae and its infections. Mikrobiyoloji Bülteni, 42(1):163.
  • Çelebi B, Karagöz A, Öktem M A, Çarhan A, Matur F, Özkazanç NK, Babür C , Kılıç S , Sözen M , Karataş A, Durmaz R (2015). Bartonella species in wild small mammals in Western Black Sea Region of Turkey . Journal of Ankara University Faculty Medicine, 62, 3, 183 – 187. doi: 10.3201/eid1804.110816
  • Diaz MH, Bai Y, Malania L, Winchell JM, Kosoy MY (2012). Development of a novel genus specific real-time PCR assay for detection and differentiation of Bartonella species and genotypes. J Clin Microbiol, 50(5), 1645-9.
  • Gutiérrez R, Krasnov B, Morick D, Gottlieb Y, Khokhlova IS, Harrus S (2015). Bartonella Infection in Rodents and Their Flea Ectoparasites: An Overview. Vector Borne Zoonotic Dis, 1, 15(1), 27–39.
  • Jardine C, Appleyard G, Kosoy MY, McColl D, Chirino-Trejo M, Wobeser G, Leighton FA (2005). Rodent-associated Bartonella in Saskatchewan. Canada Vector Borne Zoonotic Dis, 5,4,402-9. doi: 10.1089/vbz.2005.5.402.
  • Kamani J, Morick D, Mumcuoglu K, Harrus S (2013). Prevalence and Diversity of Bartonella Species in Commensal Rodents and Ectoparasites from Nigeria, West Africa, PLOS Neglected Tropical Dis. doi: 10.1371/journal.pntd.0002246.
  • Kandelaki G, Malania L , Bai Y, Chakvetadze N , Katsitadze G , Imnadze P , Nelson C , Harrus S (2016). Human Lymphadenopathy Caused by Ratborne Bartonella , Tbilisi, Georgia. Emerg Infect Dis, 22, 1 – 3. doi: 10.3201/eid2203.151823.
  • Karagöz A, Çelebi B, Şimsek, H, Taner, M, Kılıç S, Durmaz R, Ertek M (2013). Detection of Bartonella spp. in field mice (Microtus socialis) by culture and PCR. Ankara Üniv Vet Fak Derg, 60: 235-239.
  • Kevin C , Kosoy M , Lerdthusnee K, Phelan L , Bai Y , Gage K , leepitakrat W , Monkanna T , Khlaimanee N , Chandranoi K , Jones J , Coleman R (2004). Prevalence and diversity of bartonella in rodents of northern thailand: a comparison with bartonella in rodents from southern China. The American journal of tropical medicine and hygiene 70(4):429-33. doi: doi: 10.4269/ajtmh.2004.70.429.
  • Kim CM, Kim JY, Yi YH, Lee MJ, Cho MR, Shah DH, Klein TA, Kim HC, Song JW, Chong ST, O'Guinn ML, Lee JS, Lee IY, Park JH, Chae JS (2005). Detection of Bartonella species from ticks, mites and small mammals in Korea. J Vet Sci, 6(4), 327-34.
  • Koehler J E (1995) Bartonella-associated infections in HIV-infected patients AIDS. Clin Care, 7(12):97-102.
  • Kosoy M (2010). Ecological associations between bacteria of the genus Bartonella and mammals. Biol. Bull, 37, 716–724.
  • Kosoy M, Hayman DT, Chan KS. (2003) Bartonella bacteria in nature: where does population variability end and a species start? Infect Genet Evol, 12, 894-904.
  • Li D-M, Hou Y, Song X-P, Fu Y-Q, Li G-C, Li M, Eremeeva ME, Wu H-X, Pang B, Yue Y-J, Huang Y, Lu L, Wang J, Liu Q-Y (2015). High prevalence and genetic heterogeneity of rodent-borne Bartonella species on Heixiazi Island, China. Appl Environ Microbiol, 81: 7981–92.
  • Polat M, Parlak AH (2010). Infections Caused by Bartonella. Turkiye Klinikleri J Dermatol- Special Topics, 3,3,56-64.
  • Sığırcı BD, Ilgaz A (2013), Detection of the Presence of Bartonella henselae in Cats in Istanbul. Journal of The Faculty of Veterinary Medicine Istanbul University, 39 , 2, 209 – 217.
  • Vayssier TM, Rhun D Le, Bonnet S, V Cotte (2009 ). Insights in Bartonella host specificity. Ann N Y Acad Sci, 1166, 127 – 132. doi: 10.1111 / j.1749-6632.2009.04531.x. Vijay G, Billeter SA, Rood MP, Kosoy M (2012). Bartonella spp. in Rats and Zoonoses, Emerg Infect Dis, 18,4, 631–633.

Zoonotic agent: Bartonella spp in Rodents

Yıl 2021, Cilt: 32 Sayı: 1, 63 - 68, 30.06.2021
https://doi.org/10.35864/evmd.905289

Öz

Identifying the host types of zoonotic agents is one of the keys to controlling emerging infectious diseases. Worldwide studies have shown that rodents play an important role in the eco-epidemiology of bacterial and viral infectious agents. At the same time, rodents are natural reservoirs of Bartonella spp. It is important to monitor negligible pathogens such as Bartonella spp. especially in rodents that act as hosts and reservoirs, and to conduct epidemiological studies. Although it is a potential public health risk factor, a limited number of studies have been conducted in our country on the detection of Bartonella spp. In our study, existence of Bartonella spp. was investigated by real time PCR method 41 rodent samples collected from five different settlements in Turkey. A total number of six rodent spleen samples studied with real time PCR were found positive for Bartonella spp. (14.63%). As a result of our study, it was concluded that wild rodent species can be considered as possible reservoirs in the formation of the disease and further studies are needed in this area.

Kaynakça

  • Abbot P, Aviles AE, Eller L, Durden LA (2007). Mixed infections, cryptic diversity, and vector-borne pathogens: Evidence from Polygenis fleas and Bartonella species. Appl Environ Microbiol, 73:6045–6052.
  • Alexsandra Rodrigues de Mendonça Favachoa Marcelle Novaes Andradea Renata Carvalhode Oliveiraa Cibele Rodrigues Bonvicinob Paulo Sergio D'Andrea Elba Regina Sampaiode Lemosa (2015). Zoonotic Bartonella species in wild rodents in the state of Mato Grosso do Sul, Brazil Microbes and Infection, 17, 11–12, 889-892.
  • Avidor B, Graidy M, Efrat G, Leibowitz C, Shapira G, Schattner A, Zimhony O, Giladi M Bartonella infections. Koehler JE (1996). Adv Pediatr Infect Dis, 11,1-27.
  • Bermond D, Boulouis HJ, Heller R, Laere Guy Van, Monteil Henri, B Chomel Bruno, Sander Anna, Dehio Christoph, Piémont Yves (2002) Bartonella bovis sp. nov. and Bartonella capreoli sp. nov., isolated from European ruminants. Int J Syst Evol Microbiol, 52(Pt 2):383-390. doi: 10.1099/00207713-52-2-383.
  • Birtles J Richard J (2005). Bartonellae as elegant hemotropic parasites. Ann N Y Acad Sci, 1063:270-9. doi: 10.1196/annals.1355.044.
  • Breitschwerdt EB, Kordick DL (2000). Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. Clin Microbiol Rev, 13(3), 428-38.
  • Brinkerhoff RJ (2008). Mammal and Flea Occurrence in Association with Black-Tailed Prairie Dog (Cynomys Ludovicianus) Colonies: Implications for Interspecific Plague Transmission. Ph.D. Dissertation University of Colorado, Boulder, Colorado, USA.
  • Buffet JP, Kosoy M, Vayssier TM (2013). Natural history of Bartonella-infecting rodents in light of new knowledge on genomics, diversity and evolution. Future Microbiol, 8:1117–1128.
  • Chang CC, Chomel BB, Kasten RW, Heller RM, Kocan KM, Ueno H, Yamamoto K, Bleich VC, Pierce BM, Gonzales BJ, Swift PK, Boyce WM, Jang SS, Boulouis HJ, Piémont Y (2000). Bartonella spp. isolated from wild and domestic ruminants in North America. Emerg Infect Dis, 6(3):306-11.
  • Chomel B B, Abbott RC, Kasten RW, Hawkins F KA, Kass PH, Glaser CA, Pedersen NC, Koehler CE (1995). Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. Journal of Clinical Microbiology, 33 (9), 2445-2450.
  • Chomel BB, Kasten RW, Floyd-Hawkins K, Chi B, Yamamoto K, Roberts-Wilson J, Gurfield AN, Abbott RC, Pedersen NC, Koehler JE (1996). Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol, 34(8), 1952-6.
  • Chomel BB, R C Abbott, R W Kasten, K A Floyd-Hawkins, P H Kass, C A Glaser, N C Pedersen, J E Koehler 1995J Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. Clin Microbiol. Sep;33(9):2445-50. doi: 10.1128/JCM.33.9.2445-2450.1995.
  • Çelebi B (2008). Bartonella henselae and its infections. Mikrobiyoloji Bülteni, 42(1):163.
  • Çelebi B, Karagöz A, Öktem M A, Çarhan A, Matur F, Özkazanç NK, Babür C , Kılıç S , Sözen M , Karataş A, Durmaz R (2015). Bartonella species in wild small mammals in Western Black Sea Region of Turkey . Journal of Ankara University Faculty Medicine, 62, 3, 183 – 187. doi: 10.3201/eid1804.110816
  • Diaz MH, Bai Y, Malania L, Winchell JM, Kosoy MY (2012). Development of a novel genus specific real-time PCR assay for detection and differentiation of Bartonella species and genotypes. J Clin Microbiol, 50(5), 1645-9.
  • Gutiérrez R, Krasnov B, Morick D, Gottlieb Y, Khokhlova IS, Harrus S (2015). Bartonella Infection in Rodents and Their Flea Ectoparasites: An Overview. Vector Borne Zoonotic Dis, 1, 15(1), 27–39.
  • Jardine C, Appleyard G, Kosoy MY, McColl D, Chirino-Trejo M, Wobeser G, Leighton FA (2005). Rodent-associated Bartonella in Saskatchewan. Canada Vector Borne Zoonotic Dis, 5,4,402-9. doi: 10.1089/vbz.2005.5.402.
  • Kamani J, Morick D, Mumcuoglu K, Harrus S (2013). Prevalence and Diversity of Bartonella Species in Commensal Rodents and Ectoparasites from Nigeria, West Africa, PLOS Neglected Tropical Dis. doi: 10.1371/journal.pntd.0002246.
  • Kandelaki G, Malania L , Bai Y, Chakvetadze N , Katsitadze G , Imnadze P , Nelson C , Harrus S (2016). Human Lymphadenopathy Caused by Ratborne Bartonella , Tbilisi, Georgia. Emerg Infect Dis, 22, 1 – 3. doi: 10.3201/eid2203.151823.
  • Karagöz A, Çelebi B, Şimsek, H, Taner, M, Kılıç S, Durmaz R, Ertek M (2013). Detection of Bartonella spp. in field mice (Microtus socialis) by culture and PCR. Ankara Üniv Vet Fak Derg, 60: 235-239.
  • Kevin C , Kosoy M , Lerdthusnee K, Phelan L , Bai Y , Gage K , leepitakrat W , Monkanna T , Khlaimanee N , Chandranoi K , Jones J , Coleman R (2004). Prevalence and diversity of bartonella in rodents of northern thailand: a comparison with bartonella in rodents from southern China. The American journal of tropical medicine and hygiene 70(4):429-33. doi: doi: 10.4269/ajtmh.2004.70.429.
  • Kim CM, Kim JY, Yi YH, Lee MJ, Cho MR, Shah DH, Klein TA, Kim HC, Song JW, Chong ST, O'Guinn ML, Lee JS, Lee IY, Park JH, Chae JS (2005). Detection of Bartonella species from ticks, mites and small mammals in Korea. J Vet Sci, 6(4), 327-34.
  • Koehler J E (1995) Bartonella-associated infections in HIV-infected patients AIDS. Clin Care, 7(12):97-102.
  • Kosoy M (2010). Ecological associations between bacteria of the genus Bartonella and mammals. Biol. Bull, 37, 716–724.
  • Kosoy M, Hayman DT, Chan KS. (2003) Bartonella bacteria in nature: where does population variability end and a species start? Infect Genet Evol, 12, 894-904.
  • Li D-M, Hou Y, Song X-P, Fu Y-Q, Li G-C, Li M, Eremeeva ME, Wu H-X, Pang B, Yue Y-J, Huang Y, Lu L, Wang J, Liu Q-Y (2015). High prevalence and genetic heterogeneity of rodent-borne Bartonella species on Heixiazi Island, China. Appl Environ Microbiol, 81: 7981–92.
  • Polat M, Parlak AH (2010). Infections Caused by Bartonella. Turkiye Klinikleri J Dermatol- Special Topics, 3,3,56-64.
  • Sığırcı BD, Ilgaz A (2013), Detection of the Presence of Bartonella henselae in Cats in Istanbul. Journal of The Faculty of Veterinary Medicine Istanbul University, 39 , 2, 209 – 217.
  • Vayssier TM, Rhun D Le, Bonnet S, V Cotte (2009 ). Insights in Bartonella host specificity. Ann N Y Acad Sci, 1166, 127 – 132. doi: 10.1111 / j.1749-6632.2009.04531.x. Vijay G, Billeter SA, Rood MP, Kosoy M (2012). Bartonella spp. in Rats and Zoonoses, Emerg Infect Dis, 18,4, 631–633.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Tıbbi Mikrobiyoloji, Veteriner Bilimleri
Bölüm Araştırma Makaleleri
Yazarlar

Derya Karataş Yeni 0000-0001-7261-1394

Erken Görünüm Tarihi 7 Ocak 2021
Yayımlanma Tarihi 30 Haziran 2021
Gönderilme Tarihi 29 Mart 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 32 Sayı: 1

Kaynak Göster

APA Karataş Yeni, D. (2021). Zoonotik ajan: Rodentlerde Bartonella spp. Etlik Veteriner Mikrobiyoloji Dergisi, 32(1), 63-68. https://doi.org/10.35864/evmd.905289


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