Otitis eksternalı köpeklerden izole edilen Pseudomonas aeruginosa suşlarının antibiyotik direnç profilleri

Yıl 2021, Cilt: 32 Sayı: 2, 118 - 123, 30.12.2021

Tansu Bıçakcıoğlu , Şimal Yörük , Hamit Kaan Müştak

https://doi.org/10.35864/evmd.986820

Öz

Pseudomonas aeruginosa, köpeklerin otitis vakalarından sıklıkla izole edilen bir patojendir ve çoğu antibiyotiğe karşı birçok içsel ve edinilmiş direnç mekanizmasına sahip, çoklu antibiyotik direnci geliştirme kabiliyeti olduğu bilinen bir bakteridir. Bu çalışmanın amacı, otitis eksterna semptomları gösteren köpeklerden izole edilen P. aeruginosa suşlarının antibiyotik direnç profillerinin belirlenmesidir. 170 kulak sürüntüsü örneğinden toplam 43 (%26.70) P. aeruginosa suşu izole edildi ve bu suşların tümü disk difüzyon duyarlılık testine tabi tutuldu. İzole edilen P. aeruginosa suşlarının direnç profilleri trimetoprim sülfametoksazole %100, doksisikline %93,02, neomisine %79,06, oksitetrasikline %58,13, enrofloksasine %34,88, tobramisine %25,58, gentamisine %20,93, siprofloksasine %13,95, amikasine %4,30, polimiksin B’ye %4.65 şeklinde bulundu. Ayrıca toplam 17 (% 39.53) P. aeruginosa suşunda çoklu antibiyotik direnci saptandı. Sonuç olarak köpeklerin otitis eksterna vakalarından en sık izole edilen Gram-negatif bakterinin P. aeruginosa olduğu ve bu izolatların farklı gruplardan antibiyotiklere yüksek direnç gösterdiği anlaşıldı.

Anahtar Kelimeler

Antibiyotik direnci, Köpek, Otitis eksterna, Pseudomonas aeruginosa

Antibiotic resistance profiles of Pseudomonas aeruginosa strains isolated from dogs with otitis externa

Öz

Pseudomonas aeruginosa is an important pathogen that is frequently isolated from otitis cases in dogs, known to have high intrinsic and acquired resistance mechanisms to resist most antibiotics, and the ability to develop multiple antibiotic resistance. The aim of this study was to determine the antibiotic resistance profile of P. aeruginosa strains isolated from dogs with otitis externa symptoms. Totally 43 (26.70%) P. aeruginosa strains were isolated from 170 ear swab samples and all these strains were subjected to disk diffusion susceptibility testing and the resistance profiles of the strains were found to be as follows; 100% to trimethoprim sulfamethoxazole, 93.02% to doxycycline, 79.06% to neomycin, 58.13% to oxytetracycline, 34.88% to enrofloxacin, 25.58% to tobramycin, 20.93% to gentamicin, 13.95% to ciprofloxacin, 9.30% to amikacin, 4.65% to polymyxin B. Furthermore, multiple antibiotic resistance was detected in a total of 17 (39.53%) P. aeruginosa strains. As a result, it was understood that the most common Gram-negative bacteria isolated from otitis externa cases of dogs was P. aeruginosa and these isolates have shown high resistance to antibiotics from many antibiotic groups.

Anahtar Kelimeler

Antibiotic resistance, Dog, Otitis externa, Pseudomonas aeruginosa

Kaynakça

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