SAD B19'un Türkiye'de Hedef Dışı Türlerdeki Zararsızlık Testleri

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 103 - 112, 01.06.1998

Tülin Güzel Orhan Aylan Ad Vos

Öz

SAD B 19 canlı modifiye virus suşunun, köpeklerin ağız yoluyla aşılanması
için güvenirliği Türkiye'de iki ana bait alıcısında degerlendirilmiştir:
bunlar evecil kedi ve karga vb. SAD B ı 9 aşı suşuının oral uygulamaclHn
soıırcı evcil kediler ve saksağanlar için tamamen zararsız olduğu gösterilmiştir. Ayrıca toplam 81 adet yerel kemirgen (17 Mus musculus. 9 Rattus
norvegicus. 13 Microtus epiroticus. 29 Apodemus sylvaticus ve 13 Apodemus
agrarius) SAD B 19 attenue kuduz aşı virusu ile inokule edildi. Elde edilen
sonuçlar ekstrem laboratuvar şartlarında oral uygulamalarda SAD B 19'un
kalıntı seviyesinde patojenitesinin oldugunu teyit etmiştir. Bu kemirgenlerden
toplam 5'i kuduzdan ölmüştür. Bununla birlikte bu rodentlerden 3 tane
fare, aşı uygulamasından önce ether, ketamin hydrochloride ile anestelzi edilmiştir. Aşı virusu muhtemelen direkt olarak solunum yolu organlarına
uygulanmış olabilir. Aşı virusunun aynı türdeki inokule hayvanlardan
kontrol hayvanlarına nakli gözlenmemiştir. Bu da SAD B 19'un kemirgen
populasyonlar içinde yayılım eğilimi olmadığını göstermektedir.

Anahtar Kelimeler

SAD B19, Türkiye, Hedef Dışı Türler, Zararsızlık

Innocuity Tests Of SAD B19 in Turkish Nontarget Species

Öz

The safety of tl1e live modified vaccine virus SAD B 19 for oral vaccination
of dogs was evaluated in the two main bait competitors in Turkey; domestic
cats anel corvine species. It was shown that the SAD B19 vaccine virus was
completely innocuous for domestic cats anel magpies (Pica pica) after oral
application. Furthermore, a total of 81 local Turkish rodents ( 17 Mus
musculus. 9 Rattus norvegicus. 13 Microtus epiroticus. 29 Apodemus
sylvaticus anel 13 Apodemus agrarius) were inoculated orally with the
attenuated rabies vaccine virus SAD B 19. The obtained results confirm that
under laboratory conditions a residual pathogenicity of SAD B 19 for
rodents exist when administered orally. A total of five rodents died from
rabies. However. of these animals three M. musculus were anaesthetized with ether and ketamine-hydrochloride before vaccine administration.
Partly. the vaccine virus was probably directly applied in the respiratory
organs. Transmission ofvaccine virus from inoculated to control animals of
the same species was not observed. indicating that there is no tendency for
SAD B 19 to spread within rodent populations.

Kaynakça

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