Araştırma Makalesi
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SAD B19'un Türkiye'de Hedef Dışı Türlerdeki Zararsızlık Testleri

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 103 - 112, 01.06.1998

Öz

SAD B 19 canlı modifiye virus suşunun, köpeklerin ağız yoluyla aşılanması
için güvenirliği Türkiye'de iki ana bait alıcısında degerlendirilmiştir:
bunlar evecil kedi ve karga vb. SAD B ı 9 aşı suşuının oral uygulamaclHn
soıırcı evcil kediler ve saksağanlar için tamamen zararsız olduğu gösterilmiştir. Ayrıca toplam 81 adet yerel kemirgen (17 Mus musculus. 9 Rattus
norvegicus. 13 Microtus epiroticus. 29 Apodemus sylvaticus ve 13 Apodemus
agrarius) SAD B 19 attenue kuduz aşı virusu ile inokule edildi. Elde edilen
sonuçlar ekstrem laboratuvar şartlarında oral uygulamalarda SAD B 19'un
kalıntı seviyesinde patojenitesinin oldugunu teyit etmiştir. Bu kemirgenlerden
toplam 5'i kuduzdan ölmüştür. Bununla birlikte bu rodentlerden 3 tane
fare, aşı uygulamasından önce ether, ketamin hydrochloride ile anestelzi edilmiştir. Aşı virusu muhtemelen direkt olarak solunum yolu organlarına
uygulanmış olabilir. Aşı virusunun aynı türdeki inokule hayvanlardan
kontrol hayvanlarına nakli gözlenmemiştir. Bu da SAD B 19'un kemirgen
populasyonlar içinde yayılım eğilimi olmadığını göstermektedir.

Kaynakça

  • Artois M, Guittre C, Thomas I, Leblois H, Brochier B, Barrat J (1982) Potential pathogenicity for rodents of vaccines inteneleel for orcıJ vaccination against rabies: a comparison. Vaccine. 10:524-528 .
  • Beran GW (1991) Urban Rabies. In : The Natural history of rabies. 2nd ed. (Eel. Baer GM). 427-444. CRC Press. Boca Ra ton.
  • Blancou J, Meslin F-X (1996) Modified live-virus rabies vaccines for oral immunization of carnivores. In: Laboratory techniques in rabies. 4th ed. (ecls. Meslin F-X. Kaplan MM, Koprowski H) 324-337. World Health Organization, Geneva.
  • Ciuchini F, Pestalozza Al, Buonavoglia C, Di Trani L, Tollis M, Orfei Z (1986) Effects of Corticosteroids Mediated Immunosuppression on the Distribution of Rabies Vaccine Virus in Red Foxes orally immunized against Rabies. J . Vet. Med. B. 33: 628-631.
  • Ciuchini F, Bozzano Al, Pestalozza S, Tollis M (1988) Researclı on Susceptibility of Ca ts to the Oral Administration of Rabies Vaccine SAD B19 Tü. J . Vet. Med. B, 35: 677-680
  • Perry BD, Wandeler AI (1993) The clelivery of oral rabies vaccines to clogs: an African perspective. Onclerstepoort J . Vet. Res .. 60 : 451-457 .
  • Müller WW, Güzel T, Aylan O, Kaya C, Cox JH, Schneider LG (1998) The feasibility of oral vaccination of clogs in Turkey - a European Union supported project. J. Etlik Vet. Microbiol., 9:61-71
  • Schneider LG, Cox JH (1983) Ein Feldversuclı zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland. Tierarzt. Umschau. 38:315-324.
  • Steck F, Wandeler Al, Bischel P, Capt S, Hilliger U, Schneider LG (1982) Oral immunization of foxes against rabies . Laboratory anel field studies. Comm. Immun. Microbiol. infect. Dis .. 5 : 165- 171
  • Vantorre R (1994) Zelf inloopvallen m"ctken. Zoogdier. 5(1 ): 20-23.
  • V os A, Şanlı S (1998) Evaluation of a bait delivery systemsfor oral vaccination of dogs against rabies in Turkey. J. Etlik Vet. Microbiol.. 9:83-91
  • Wandeler Al, Bauder W, Prochaska S, Steck F (1982) Small manımal studies in a SAD baiting area. Comm. Immun. Microbiol. infect Dis .. 5:173 -176.
  • WHO ( 1989) Report of the WHO Consultation on requirements and criteria for field trials on oral rabies vaccination of dogs and wild carnivores. Rab.Res./89 .32. World Health Organization, Geneva

Innocuity Tests Of SAD B19 in Turkish Nontarget Species

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 103 - 112, 01.06.1998

Öz

The safety of tl1e live modified vaccine virus SAD B 19 for oral vaccination
of dogs was evaluated in the two main bait competitors in Turkey; domestic
cats anel corvine species. It was shown that the SAD B19 vaccine virus was
completely innocuous for domestic cats anel magpies (Pica pica) after oral
application. Furthermore, a total of 81 local Turkish rodents ( 17 Mus
musculus. 9 Rattus norvegicus. 13 Microtus epiroticus. 29 Apodemus
sylvaticus anel 13 Apodemus agrarius) were inoculated orally with the
attenuated rabies vaccine virus SAD B 19. The obtained results confirm that
under laboratory conditions a residual pathogenicity of SAD B 19 for
rodents exist when administered orally. A total of five rodents died from
rabies. However. of these animals three M. musculus were anaesthetized with ether and ketamine-hydrochloride before vaccine administration.
Partly. the vaccine virus was probably directly applied in the respiratory
organs. Transmission ofvaccine virus from inoculated to control animals of
the same species was not observed. indicating that there is no tendency for
SAD B 19 to spread within rodent populations.

Kaynakça

  • Artois M, Guittre C, Thomas I, Leblois H, Brochier B, Barrat J (1982) Potential pathogenicity for rodents of vaccines inteneleel for orcıJ vaccination against rabies: a comparison. Vaccine. 10:524-528 .
  • Beran GW (1991) Urban Rabies. In : The Natural history of rabies. 2nd ed. (Eel. Baer GM). 427-444. CRC Press. Boca Ra ton.
  • Blancou J, Meslin F-X (1996) Modified live-virus rabies vaccines for oral immunization of carnivores. In: Laboratory techniques in rabies. 4th ed. (ecls. Meslin F-X. Kaplan MM, Koprowski H) 324-337. World Health Organization, Geneva.
  • Ciuchini F, Pestalozza Al, Buonavoglia C, Di Trani L, Tollis M, Orfei Z (1986) Effects of Corticosteroids Mediated Immunosuppression on the Distribution of Rabies Vaccine Virus in Red Foxes orally immunized against Rabies. J . Vet. Med. B. 33: 628-631.
  • Ciuchini F, Bozzano Al, Pestalozza S, Tollis M (1988) Researclı on Susceptibility of Ca ts to the Oral Administration of Rabies Vaccine SAD B19 Tü. J . Vet. Med. B, 35: 677-680
  • Perry BD, Wandeler AI (1993) The clelivery of oral rabies vaccines to clogs: an African perspective. Onclerstepoort J . Vet. Res .. 60 : 451-457 .
  • Müller WW, Güzel T, Aylan O, Kaya C, Cox JH, Schneider LG (1998) The feasibility of oral vaccination of clogs in Turkey - a European Union supported project. J. Etlik Vet. Microbiol., 9:61-71
  • Schneider LG, Cox JH (1983) Ein Feldversuclı zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland. Tierarzt. Umschau. 38:315-324.
  • Steck F, Wandeler Al, Bischel P, Capt S, Hilliger U, Schneider LG (1982) Oral immunization of foxes against rabies . Laboratory anel field studies. Comm. Immun. Microbiol. infect. Dis .. 5 : 165- 171
  • Vantorre R (1994) Zelf inloopvallen m"ctken. Zoogdier. 5(1 ): 20-23.
  • V os A, Şanlı S (1998) Evaluation of a bait delivery systemsfor oral vaccination of dogs against rabies in Turkey. J. Etlik Vet. Microbiol.. 9:83-91
  • Wandeler Al, Bauder W, Prochaska S, Steck F (1982) Small manımal studies in a SAD baiting area. Comm. Immun. Microbiol. infect Dis .. 5:173 -176.
  • WHO ( 1989) Report of the WHO Consultation on requirements and criteria for field trials on oral rabies vaccination of dogs and wild carnivores. Rab.Res./89 .32. World Health Organization, Geneva
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Tülin Güzel Bu kişi benim

Orhan Aylan Bu kişi benim

Ad Vos Bu kişi benim

Yayımlanma Tarihi 1 Haziran 1998
Gönderilme Tarihi 1 Ocak 1998
Yayımlandığı Sayı Yıl 1998 Cilt: 9 Sayı: Özel Sayı

Kaynak Göster

APA Güzel, T., Aylan, O., & Vos, A. (1998). SAD B19’un Türkiye’de Hedef Dışı Türlerdeki Zararsızlık Testleri. Etlik Veteriner Mikrobiyoloji Dergisi, 9(Özel Sayı), 103-112.


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