Derinin Bağışıklık Sistemindeki Rolü
Yıl 1999,
Cilt: 10 Sayı: 1, 31 - 45, 01.06.1999
Sibel Özkök
Hakan Yardımcı
Öz
Bu derlemede, vücudun en geniş organı olan derinin asıl görevlerinin yanında bağışıklık sistemini tamamlayıcı görevleri anlatılmaktadır.
Deri, vücudun dış yÜzünü örterek genel özellikleri ile koruyucu
görev üstlenmiş organlardan oluşan bir sistemdir. Geniş anlamdaki
görevi vücudu örtrnek olan deri, genellikle keratinleşmiş ve geçirgen
olmayan epidermis ve kıllarla kaplıdır
Kaynakça
- ARDA M, (1985). İmmunoloji (Bağışıklık Bilimi}, Edt.: Arda,
M. , Ankara Üniversitesi Basımevi. Ankara. pp:18-19.
- BOS J D, TEUNISSEN M B M, KAPSENBERG ML, (1989).
Immunology oj contact dermatitis. Acta. Derın. Venerol. (Stockh). 69
(Suppl. 151), 55.
- BOTHAM PA, RATTRAY N J, WALSH ST, RILEY E J,
(1987). Control oj the immune response to contact sensitizing chemicals
by cutaneous antigen-presenting cells. Br. J. Dermatol. 117: 1-9.
- BREATHNACH S M, (1986). Do epidermotropic T cells exist in
normal human slcin. A re-evaluation oj the SALT hypothesis. Br. J .
Dermatol. 115: 389-392.
- CERIO R, GRIFFITHS C E M, COOPER K D, NICKOLOFF
B J, READINGTON J T, (1987). Characterization oj jactor XIIa positive
dermal dendritic cells in normal and injlamed slcin. Br. J. Dermatol.
121: 421-431.
- DOWD PM, HUDSPITH B N, MILLER J A, BARR RM,
BROSTOFF J, GREAVES M W, (1987). Release in vivo oj IL-1 lilce activity
by human slcin. Clin. Exp. Immunol. 67 : 606-610.
- DE PANFILIS G, MANARA G C, FERRARI C, (1986). Immunogold
iabeliing oj ep idermal Langerhans cells on tissue sections oj human
slcin. Br. J. Dermatol. 115: 351-356.
- EDELSON R L, FINK J M, (1980). The immunologicjunction
oj slcin. Sci. American. 252(6): 34-41.
- GREENWAY HT, CORNELL RC, (1990) . Interferon. Arch.
Dermatol. 126: 1080- 1082.
- HALLIWELL RE W, GüRMAN NT, (1989). Atopic Disease.
In "Veterinary Clinical Immunology" Edt.: Halliwell, R.E.W., Gorman.
N.T .. W.B. Sounders Company, Philadelphia pp: 232-252.
- HOLGATE ST, ROBINSON C, CHURCH K, (1989). The
centribution oj mast cell mediators to acute allergic reactions in human
slcin and airways. Allergy. 5: 22-31 .
- LEUNG D Y M, SCHNEEBERGER E E, SIRAGANIAN RP,
GEHA R S, BHAN A K, (1987). The presence oj macrophages and
dendritic cells injiltrating into the s Icin lesion oj atopic dermatitis. Clin.
Immunol. Immunopathol. 42: 328-337.
- LUGER TA, (1989). Epidermal cytokines. Acad. Derm. Venereal.
69 (Supp-151): 61-76.
- MOLL H, (1993) . Epidermal Langerhans cells are criticaljor
immunoregulation oj cutaneous leishmaniasis. Immunol. Taday. 14(8):
383-387.
- OLLIER S, (1992) . Cutaneous respanses a window on injlamatory
processes. Clin. Exp. Allergy. 22: 3-6.
- PARISH W E, (1969). Effectors oj immunological responses:
their expressian and modes oj action in slcin. In "Immunology and the
slcin". Edt: Montagne, W., Bilingham, R.E. Appleton-Century-Crofts ,
New York, pp.: 1-5.
- RINGLER DJ, HANCOCK W W, KING N W, MUNPHY G F,
(1987). Characterization oj nonhuman primate ep idermal and dermal
dendritic cells with monoclonal antibodies. Lab. Invents. 56(3): 313-
320.
- ROSE N R, (1985) . Origins oj the immune response. Dermatol
Immuno/. Allergy. 3- 14 .
- SHIMADA S, KATZ S I, (1989) . The slcin as an immunologic
organ. Arch. Pathol. Lab. Med. 112 : 231 - 234 .
- SONTHEIMER R D, (1993). Antibodies inside our lceratinocytes?
Arch. Dermatol. 129: 1184-1186.
- TALLY FP (1989). Slcin and sojt tissue. In "Mechanisme oj
microbial disease, Section III". Edt.: Schechter, M. Willliams and Wilkins,
Baltimore. pp. : 682-696.
- THESTRUP-PEDERSEN K, (1989) . Immunology oj atopic
dermatitis. Acta. Dermatol. Venereal. 69 (Supp: 151): 77-83.
- VAN LAMBALGEN R, WAUBEN-PENRIS P J J, (1989). Conceps
in immuno-dermatology. 69 (Supp: 151): 56-60.
Yıl 1999,
Cilt: 10 Sayı: 1, 31 - 45, 01.06.1999
Sibel Özkök
Hakan Yardımcı
Öz
In this study it is rewieved that the skin which is the largest organ
of the body has complementary functions besides its main functions.
Kaynakça
- ARDA M, (1985). İmmunoloji (Bağışıklık Bilimi}, Edt.: Arda,
M. , Ankara Üniversitesi Basımevi. Ankara. pp:18-19.
- BOS J D, TEUNISSEN M B M, KAPSENBERG ML, (1989).
Immunology oj contact dermatitis. Acta. Derın. Venerol. (Stockh). 69
(Suppl. 151), 55.
- BOTHAM PA, RATTRAY N J, WALSH ST, RILEY E J,
(1987). Control oj the immune response to contact sensitizing chemicals
by cutaneous antigen-presenting cells. Br. J. Dermatol. 117: 1-9.
- BREATHNACH S M, (1986). Do epidermotropic T cells exist in
normal human slcin. A re-evaluation oj the SALT hypothesis. Br. J .
Dermatol. 115: 389-392.
- CERIO R, GRIFFITHS C E M, COOPER K D, NICKOLOFF
B J, READINGTON J T, (1987). Characterization oj jactor XIIa positive
dermal dendritic cells in normal and injlamed slcin. Br. J. Dermatol.
121: 421-431.
- DOWD PM, HUDSPITH B N, MILLER J A, BARR RM,
BROSTOFF J, GREAVES M W, (1987). Release in vivo oj IL-1 lilce activity
by human slcin. Clin. Exp. Immunol. 67 : 606-610.
- DE PANFILIS G, MANARA G C, FERRARI C, (1986). Immunogold
iabeliing oj ep idermal Langerhans cells on tissue sections oj human
slcin. Br. J. Dermatol. 115: 351-356.
- EDELSON R L, FINK J M, (1980). The immunologicjunction
oj slcin. Sci. American. 252(6): 34-41.
- GREENWAY HT, CORNELL RC, (1990) . Interferon. Arch.
Dermatol. 126: 1080- 1082.
- HALLIWELL RE W, GüRMAN NT, (1989). Atopic Disease.
In "Veterinary Clinical Immunology" Edt.: Halliwell, R.E.W., Gorman.
N.T .. W.B. Sounders Company, Philadelphia pp: 232-252.
- HOLGATE ST, ROBINSON C, CHURCH K, (1989). The
centribution oj mast cell mediators to acute allergic reactions in human
slcin and airways. Allergy. 5: 22-31 .
- LEUNG D Y M, SCHNEEBERGER E E, SIRAGANIAN RP,
GEHA R S, BHAN A K, (1987). The presence oj macrophages and
dendritic cells injiltrating into the s Icin lesion oj atopic dermatitis. Clin.
Immunol. Immunopathol. 42: 328-337.
- LUGER TA, (1989). Epidermal cytokines. Acad. Derm. Venereal.
69 (Supp-151): 61-76.
- MOLL H, (1993) . Epidermal Langerhans cells are criticaljor
immunoregulation oj cutaneous leishmaniasis. Immunol. Taday. 14(8):
383-387.
- OLLIER S, (1992) . Cutaneous respanses a window on injlamatory
processes. Clin. Exp. Allergy. 22: 3-6.
- PARISH W E, (1969). Effectors oj immunological responses:
their expressian and modes oj action in slcin. In "Immunology and the
slcin". Edt: Montagne, W., Bilingham, R.E. Appleton-Century-Crofts ,
New York, pp.: 1-5.
- RINGLER DJ, HANCOCK W W, KING N W, MUNPHY G F,
(1987). Characterization oj nonhuman primate ep idermal and dermal
dendritic cells with monoclonal antibodies. Lab. Invents. 56(3): 313-
320.
- ROSE N R, (1985) . Origins oj the immune response. Dermatol
Immuno/. Allergy. 3- 14 .
- SHIMADA S, KATZ S I, (1989) . The slcin as an immunologic
organ. Arch. Pathol. Lab. Med. 112 : 231 - 234 .
- SONTHEIMER R D, (1993). Antibodies inside our lceratinocytes?
Arch. Dermatol. 129: 1184-1186.
- TALLY FP (1989). Slcin and sojt tissue. In "Mechanisme oj
microbial disease, Section III". Edt.: Schechter, M. Willliams and Wilkins,
Baltimore. pp. : 682-696.
- THESTRUP-PEDERSEN K, (1989) . Immunology oj atopic
dermatitis. Acta. Dermatol. Venereal. 69 (Supp: 151): 77-83.
- VAN LAMBALGEN R, WAUBEN-PENRIS P J J, (1989). Conceps
in immuno-dermatology. 69 (Supp: 151): 56-60.