Antifriz proteinler

Yıl 2007, Cilt: 18 Sayı: 1-2, 27 - 32, 01.12.2007

Gizem Işıl Bektaş Arif Altıntaş

Öz

İlk kez Antartik sularda yaşayan Notothenioid’lerde varlığı gösterilen Antifriz proteinler (AFGP ve AFP) her biri üç amino asitlik bir peptid zincirinin üçüncü amino asidine kovalan bağlarla bağlanmış bir disakkarit molekülünden oluşan birimlerin (alanin-alanin-threonin-galaktozil-N-asetilgalaktozamin)n tekrarlanması ile meydana gelen bir glikopeptid yapıdadır. Bu glikopeptidler balığın derisinden vücuda giren ufacık buz kristallerine hidroksil grupları (-OH), diğer polar grupları ve amino asit zincirlerindeki karbonil (=C=O) grupları ile tutunup, kristallerin büyümesini önleyerek canlıyı donmaya karşı korumaktadır. Antifriz proteinlerin tripsinojen genin birtakım çoğalmaları sonucunda oluştuğu ve karaciğer ve deri kaynaklı olabileceği, antifriz protein ailesinin bitki ve böcek tipine ek olarak 5 tip proteini kapsadığı saptanmıştır. Günümüzde bu proteinler tıp, gıda ve endüstri alanlarında etkin biçimde kullanılmaktadır.

Anahtar Kelimeler

Etlik veterinerlik Mikrobiyoloji Dergisi, Antifriz, Protein, Gizem Işıl BEKTAŞ, Arif ALTINTAŞ, 2007

Antifreeze Proteins

Öz

Antifreeze proteins first found in the Notothenioid in Antartic ocean. The protein consist of a repeated glycopeptide, Ala-Ala-Thr-galactosyl-N-acetyl galactosamine. These glycopeptides made bond with hydroxyl (-OH) and carbonyl (=C=O) groups to the ice crystal to prevent freezing. While ice crystal was entering the skin antifreeze proteins bind to ice crystal, by this way crystal growth can be stopped. Evolution of antifreeze glycoprotein gene from a trypsinogen gene and origin from skin or liver. Antifreeze proteins family has 5 type of protein, plant and insect form. Nowadays antifreeze proteins are common used in foods, medical and industrial area.

Kaynakça

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