CİVCİVLERDE DENEYSEL A VİAN ENCEPHALOMYELİTİS HASTALIGINDA KLİNİK VE HiSTOPATOLOJiK BULGULARlN İNCELENMESİ

Yıl 1997, Cilt: 9 Sayı: 2, 31 - 46, 26.07.2022

Yavuz Selim Sağlam Hüdaverdi Erer

Öz

Bu çalışmada, A vian Encephalomyelitis (AE) hastalığı deneysel yolla
oluşturularak, klinik ve histopatolojik bulgulan incelenmiş, çabuk ve doğru
teşhis konulmasında histopatolojik bulguların önemi araştırılmıştır. Van Roekel
suşu ile intraserebral olarak inakule edilen SPF civcivlerin tamamında,
inokulasyonun 6. gününden itibaren klinik bulgulara rastlandı. 24 civcivde
ataksi, 20 civcivde parez ve paraliz, 12 civcivde tremor ve 8 civcivde toıtikollis
vardı. Santral sinir sisteminde rastlanan histopatolojik bulgular oldukça
şiddetli olup, nöronal dejenerasyon , santral kromatoliz ~ gliozis ve perivasküler
mononükleer hücre infiltrasyonları ile karakterize dissemine nonpurulent
akut encephalomyelitis tablosu görünümündeydi. -Perifer sinirlerde herhangi
bir bulguya rastlanmadı.
Deneme civcivlerinin tamamında santral sinir sistemi lezyonları oluştu
ve hastalığın erken safhasında dejeneratif ve nekrotik bulgular belirgin
iken sonraki safhalarında selüler değişiklikler tabloya hakimdi. AE için patognomik
bulgu kabul edilen santral kromatoliz, belirgin olarak inakulasyondan
sonraki iki haftada görüldü. İnokulasyonun üçüncü haftasından itibaren
nöronlarda dejeneratif ve nekrotik değişikliklerin azaldığı dikkati çekti. Hastalığın
her safhasında ve belli bir lokalizasyona sahip olmaksızın tüm santral
sinir sisteminde fokal ve diffuz gliozise rastlandı ve özellikle de hastalığın_
son dönemlerinde serebellumun sıratum molekülare tabakasında çok belirgindi.
Viseral organlarda gözlenen histopatolojik bulgular ise, mononüklear
hücre infiltrasyonu ile karakterize olup, belirgin olarak pankreas, bezsel inide,
kassel mide ve karaciğerdeydi.

Anahtar Kelimeler

Avian, encephalomyelitis, civciv, deneysel, patoloji, 1997, Etlik Veteriner Mikrobiyoloji Dergisi, Yavuz Selim SAĞLAM, Hüdaverdi ERER

CLINIC AND HISTOPATHOLOGICAL SIGNS ON EXPERiMENT AL INFECTION OF A VIAN ENCEPHALOMYELITIS IN CHICKEN

Öz

In this study, A vian encephalomyelitis (AE) w as experimentally in du- ,
ced and histopathological findings were evaluated in detail and the importance
of histopathological criteria in rapid and accurate diagnosis was investigated.
Spesific pathogene free (SPF) chicks were intracerebellary inoculated
with Van Roekel strain and the first clinic symptoms were seen 6-9 days after
the inoculation. All of the chtcks in investigation exhibited clinic symptoms
of AE. In all of the 24 chicks which were necropsied periodically, ataxia
characteristic for the diesase; in 20 chicks paresis and paralysis; in 12
chicks tremors; and 8 chicks torticollis was noted. At necropsy, chicks were
emaciated .
Histopathologicallesions in central nervous system were quite extensive
and of a disseminated nonpurulent acute encephalomylitis characterised
by mononuclear cell infiltrations . There w ere not any pathologicallesions in
peripheric nerves .
Central nervous system lesions were found in all the experimental
checks and at early stage of the disease degenerative and necrotic changes
predominated where as at later stages of the disease cellular changes were remarkable.
Central chromatolysis that is spesific for AE was seen on the 7. -
14. days post inatulation and after the third week of inoculation neurons showed
reversible changes trying to get their normal structure.
Focal and diffuse gliosis w as seen at every stage of the disease and gliosis
was seenin every part of central nervous system, particularly in stratum
moleculare of cerebellum during the later stages of disease. Histopathologicallesions
in viscera were characterised by mononuclear infiltration and were
notedin the pancreas , proventriculus, gizzard and liver.

Anahtar Kelimeler

Avian encephalomyelitis, chicken, experimental, pathology., pathology

Kaynakça

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