Quorum Sensing

Yıl 2014, Cilt: 25 Sayı: 1, 25 - 32, 01.12.2014

İnci Başak Kaya Hakan Yardımcı

Öz

Günümüzde hücreler arası iletişim ve işbirliğinin sadece ökaryotlarda olmadığı prokaryotlarda da hücreler arası
iletişimin var olduğu anlaşılmıştır. Bakteriler arası bu iletişim quorum sensing (QS) olarak tanımlanmaktadır. Quorum
sensing bakteriye çok hücreli organizma gibi davranma yeteneği kazandırmaktadır. Bakteriler, diğer bakteriler tarafından
üretilen ve oto indükleyici olarak adlandırılan küçük hormon benzeri molekülleri spesifik deteksiyon sistemleri
kullanarak uyarıcı düzeydeki konsantrasyonlarını tespit eder. Böylece gen ekspresyonlarını ve dolayısıyla davranışlarını
değiştirirler. Bakteri, bu sinyal-yanıt sistemini kullanarak, popülasyon düzeyinde bireysel davranışlarını sekronize eder
ve çok hücreli organizma gibi davranır. Bu makale de prokaryotik hücreler arası ve prokaryot ile ökaryotik hücreler arası
quorum sensing mekanizmaları derlenmiştir.

Anahtar Kelimeler

Quorum sensing, prokaryot, regülon, ökaryot, iletişim., Hakan YARDIMCI, İnci Başak KAYA, Etlik Veteriner Mikrobiyoloji Dergisi, 2014

Quorum Sensing

Öz

Nowadays, cell to cell communication and co-operation has been proved to be not only found in eukaryotes,
but also in prokaryotes. In bacteria, this communication is termed quorum sensing (QS). QS enables bacteria to
act as multicellular organisms. Bacteria determine small hormone-like molecules termed auto inducer which produced
by another bacteria by using specific detection systems. Thus, they transform gene expression, and therefore behavior.
Using these signal-response systems, bacteria synchronize particular behavior on a population wide scale and function
as multicellular organisms. In this article, mechanism of cell to cell communication between prokaryotic cell and prokaryote
and eukaryotic cells are considered.

Anahtar Kelimeler

Communication, eukaryote, prokaryote, regulon, quorum sensing.

Kaynakça

• Ansaldi M, Marolt D, Stebe T, Mandic-Mulec I, Dubnau D, (2002). Specific activation of the Bacillus quorumsensing systems by isoprenylated pheromone variants. Mol Microbiol. 44, 1561-73.
• Dagkessamanskaia A, Moscoso M, Henard V, Guiral S, Overweg K, Reuter M, Martin B, Wells J, Claverys JP, (2004). Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells. Mol Microbiol. 51, 1071-86.
• Gallio M, Sturgill G, Rather P, Kylsten P, (2002). Aconserved mechanism for extracellular signaling in eukaryotes and prokaryotes. Proc Natl Acad Sci. USA 99, 12208-13.
• Gould TA, Schweizer HP, Churchill ME, (2004). Structure of the Pseudomonas aeruginosa Acyl-homoserinelactone synthase LasI. Mol Microbiol. 53, 1135-46.
• Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW, (2001). Quorum-sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol. 67, 2982- 2992.
• Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM, (2004). Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell. 15, 677-87.
• Nakayama J, Cao Y, Horii T, Sakuda S, Akkermans AD, De Vos WM, Nagasawa H, (2001). Gelatinase biosynthesis- activating pheromone: a peptide lactone that mediates a quorum sensing Enterococcus faecalis. Mol. Microbiol. 41, 145-54.
• Peterson SN, Sung CK, Cline R, Desai BV, Snesrud EC, Luo P, Walling J, Li H, Mintz M, Tsegaye G, Burr PC, Do Y, Ahn S, Gilbert J, Fleischmann RD, Morrison DA, (2004). Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays. Mol Microbiol. 51, 1051-70.
• Schuster M, Lostroh Cp, Ogi T, Greenberg EP, (2003). Identification, timing, and signal specifity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J Bacteriol. 185, 2066-79.
• Schuster M, Sexton DJ, Diggle SP, Greenberg EP, (2013). Acyl-homoserine lactone quorum-sensing: from evolution to application. Annu Rev Microbiol. 67, 43-63.
• Smith RS, Iglewski BH, (2003). P.aeruginosa quorumsensing systems and virulence. Curr Opin Microbiol. 6, 56-60.
• Vannini A, Volpari C, Gargioli C, Muraglia E, Cortese R, De Francesco R, Neddermann P, Marco SD, (2002). The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA. EMBO J. 21, 4393-401.
• Wagner VE, Bushnell D, Passador L, Brooks AI, Iglewski BH, (2003). Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J Bacteriol. 185, 2080-95.
• Waters CM, Bassler BL, (2005). Quorum-sensing: cell-tocell communication in Bacteria. Annu Rev Cell Dev. Biol. 21, 319-46.
• Zhu J, Miller MB, Vance RE, Dziejman M, Bassler BL, Mekalanos JJ, (2002). Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci. USA 99, 3129-34.