Salmonella patojenite adaları (1-10)

Yıl 2011, Cilt: 22 Sayı: 2, 79 - 82, 29.12.2011

Elçin Günaydın Selahattin Şen

Öz

Patojenite adaları üzerinde lokalize olan virulens genleri, Salmonella enterica infeksiyonlarının patogenezisinde, çok önemli bir rol oynamaktadır. Bu patojenite adalarının yapısı, fonksiyonu, Salmonella serovarları arasındaki dağılımı, belirgin bir farklılık gösterse de, Salmonella patojenite adaları arasında birçok ortak motif vardır. Günümüze kadar identifiye edilen toplam 16 adet Salmonella patojenite adası mevcuttur. Bu derlemede, bunlardan sadece 10 patojenite adasına değinilmektedir.

Anahtar Kelimeler

Elçin GÜNAYDIN, Selahattin ŞEN, Salmonella, patojenite adası

Salmonella pathogenicity islands (1-10)

Öz

Virulence genes located on pathogenicity islands play a crucial role in the pathogenesis of Salmonella enterica infections. Altough the structure, function and distribution of these pathogenicity islands among Salmonella serovars show markedly difference, several common motifs are peresent among Salmonella pathogenicity islands. Currently, identified total 16 Salmonella pathogenicity islands are peresent. In this review, of them all, 10 pathogenicity islands are mentioned.

Anahtar Kelimeler

Salmonella, pathogenicity islands

Kaynakça

• Schmidt H, Hensel M, (2004). Pathogenicity islands in bacterial pathogenesis. Clin Microbiol Rev. 17, 14-56.
• Groisman EA, Ochman H, (1996). Pathogenicity islands: bacterial evolution in quantum leaps. Cell. 87, 791-794.
• Sandra LM, Brumell JH, Pfeifer CG, Finlay BB, (2000). Salmonella pathogenicty islands: big virulence in small packages. Microb and Infec. 2, 145-156.
• Hensel M, (2004). Evolution of pathogenicity islands of Salmonella enterica. Int J Med Biol. 291, 95-102.
• Collazo CM, Galan JE, (1997), The invasion-associated type-III protein secretion system in Salmonella. Gene. 192, 51-59.
• Groisman EA, Ochman H, (1997). How Salmoella became a pathogen. Trends in Microbiol. 5, 343-349.
• Suarez M, Rüssmann, (1998). Molecular mechanisms of Salmonella invasion: the type III secretion system of the pathogenicity island 1. Microbiol. 1, 197–204.
• Jones BD, Falkow S, (1994). Identification and characterization of a Salmonella typhimurium oxygen-regulataed gene required for bacterial internalization. Infect Immun. 62, 3745-3752.
• Fu Y, Galan JE, (1998). The Salmonella typhimurium tyrosine phosphatase SptPis translocated into host cells and distrupts the actin cytoskeleton. Mol Micobiol. 27, 359-368.
• Hensel M, Shea JE, Baumler AJ, Gleeson C, Blattner FR, Holden DW, (1997). Analysis of boundaries of Salmonella pathogenicity island 2 and the corresponding choromosomal region of Escherichia coli K-12. J Bacteriol. 179, 1105-1111.
• Hensel M, Nikolaus T, Egelseer C, (1999a). Molecular and functional analysis indicates mosaic structure of Salmonella pathogenicity Island 2. Mol Microbiol. 31, 489-498.
• Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC, (1999b). The genetic basis of Salmonella Typhimurium. Mol Microbiol. 32, 275-288.
• Hensel M, Shea JE, Waterman SR, Mundy R, Nikolaus T, Banks G, Vazquez-Torres A, Gleeson C, Fang FC, Holden DW, (1998). Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. Mol Microbiol. 30, 163-174.
• Blanc-Potard AB, Solomon F, Kayser J, Groisman EA, (1999). The SPI-3 pathogenicity islands of Salmonella enterica. J Bacteriol. 181, 998-1004.
• Amavisit P, Lightfoot D, Browning GF, Markham PF, (2003). Variation between pathogenic serovars within Salmonella pathogenicity islands. J Bacteriol. 185, 3624-3635.
• Wong KK, McClelland M, Stillwell LC, Sisk EC, Thurston SJ, Saffer JD, (1998). Identification and sequence analysis of a 27-kilobase chromosomal fragment containing a Salmonella pathogenicity island located at 92 min on the choromosome map of Salmonella enterica serovar typhimurium LT2. Infect Immun. 66, 3365-3371.
• Chen LM, Kaniga K, Galan JE, (1996). Salmonella spp. are cytotoxic for cultured macrophages. Proc Natl Acad Sci. USA. 93, 4197-4201.
• Parkhill J, Dougan G, James KD, Thomson NR, Bentley SD, Holden MT, Sebaihia M, Baker S, Basham D, Brooks K, Chilingworth T, Connerton P, Cronin A, Davis P, Davies RM, Dowd L, White N, Farrar J, Feltwell T, Hamlin N, Haque A, Hien TT, Holroyd S, Jagels K, Krogh A, Larsen TS, Leather S, Moule S, O’Gora P, Parry C, Quail M, Rutherford K, Simmonds M, Skelton J, Stevens K, White head S, Barrell BG, (2001). Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature. 413,848-852
• Folkesson A, Lofdahl S, Normark S, (2002). The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells. Res Microbiol. 153, 537-545.
• Zhang XL, Morris C, Hackett J, (1997). Molecular clonning, nucleotide sequences, and function of a site-specific recombinase encoded in the major ‘pathogenicity island’ of Salmonella Typhi. Gene. 202, 139-146.
• Hansen-Wester I, Hensel M, (2002). Genome based identification of choromosomal regions specific for Salmonella spp. Infect Immun. 70, 2351-2360.
• Seth-Smith HMB, (2008). SPI-7: Salmonella’s Vi-encoding pathogenicity island. J. Infect. Developing Countries. 2, 267-271.
• Pickard D, Wain J, Baker S, Line A, Chohan S, Fookes M, Barron A, Gaora PO, Chabalgoity JA, Thanky N, Scholes C, Thomson N, Quail M, Parkhill J, Dougan G, (2003). Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7. J Bacteriol. 185, 5055-5065.
• Saroj SD, Shashidhar R, Karani M, Bandekar JR, (2008). Distribution of Salmonella pathogenicity island SPI-8 and SPI-10 among different serotypes of Salmonella. J Med Microbiol, 57, 424-427.
• Towsend SM, Kramer NE, Edwards R, Baker S, Hamlin N, Simmonds M, Stevens K, Maloy S, Parkhill J, Dougan G, Baumbler AJ, (2001). Salmonella enterica serovar Typhi posseses a unique repertoire of fimbrial gene sequences. Infect Immun. 69, 2894-2901.