FOLİKÜLER DENDRİTİK HÜCRELER

Yıl 2006, Cilt: 4 Sayı: 2, 103 - 107, 30.03.2006

Dürrin Özlem Dabak Fatih Sönmez

https://izlik.org/JA25KE76CK

Öz

Foliküler
dendritik hücre (FDH)’ler  lenf
düğümleri, dalak ve tonsillalardaki lenf foliküllerinde bulunurlar. Antijen
sunan bu hücreler komşu lenfoid hücrelerin arasına uzanan çok sayıda
sitoplazmik uzantılar (dendrit) ile karekterizedirler. FDH’ler germinal
merkez  mikroçevresinin bir anahtar
hücresel kompenenti olarak bi-linmektedir. Bu hücreler antijen antikor
kompleksini elde edip korur, hafıza B hücrelerini uyarabilir ve sonra daha
ileri T hücre aktivitesini uyarabilirler. Antijen, yerleştiği FDH’ler üzerinde
uzun zaman kalır ve bu özel-lik bazı enfeksiyon hastalıkları için çok
önemlidir. Bu derlemede FDH’ler geniş bir bakış açısından incelen-mişlerdir.

Anahtar Kelimeler

Foliküler Dendritik Hücreler , Antijen Sunan Hücreler , Antijenik Uyarım

Kaynakça

• 1. Aguzzi A, Miele G. Recent advances in prion biology. Curr Opin Neurol 2004; 17(3): 337-342.
• 2. Alavaikko MJ, Hansmann ML, Nebendahl C, Parwaresch MR, Lennert K. Follicular dendritic cells in Hodgkin's disease. Am J Clin Pathol. 1991; 95(2): 194-200.
• 3. Butch AW, Hug BA, Nahm MH. Properties of human follicular dendritic cells purified with HJ2, a new monoclonal antibody. Cell Immunol. 1994; 155(1): 27-41.
• 4. Dijkstra CD, Kamperdijk EWA, Döpp EA. The ontogenetic development of the follicular dendritic cell. An ultrastructural study by means of intravenously injected horseradish peroxidase (HRP)-anti-HRP complexes as marker. Cell Tissue Res 1984; 236: 203-206.
• 5. Georgalas C, Kanagalingam J, Gallimore A, O'Flynn P. Follicular dendritic cell sarcoma arising from the hypopharynx. J Laryngol Otol. 2004; 118(4): 317-8.
• 6. Gerdes J, Stein H, Mason DY, Ziegler A. Human dendritic reticulum cells of lymphoid follicles: their antigenic profile and their identification as multi-nucleated giant cells. Virchows Arch B. 1983; 42:161-172.
• 7. Groscurth P. Non-lymphatic cells in the lymph node cortex of the mouse . II. Postnatal development of the interdigitating cells and the dendritic reticular cells. Pathol Res Pract 1980; 169: 235-254.
• 8. Hanna MG, Szakal AK. Localization of 125I-labeled antigen in germinal centers of mouse spleen: histologic and ultrastructural autoradiographic studies of the secondary immune reaction. J Immunol. 1968; 101(5): 949-962.
• 9. Heikenwalker M, Prinz M, Heppner FL, Agguzi A. Current concepts and controversies in prion immunopathology. J Mol Neurosci. 2004; 23(1-2): 3-12.
• 10. Heusermann U, Zurborn KH, Schroeder L, Stutte MJ. The origin of the dendritic reticulum cell. An experimentalenzyme-histochemical and electron microscopic study on the rabbit spleen. Cell Tissue Res 1980; 209: 279-294.
• 11. Hur DY, Kim DJ, Kim S, Kim YI, Cho D, Lee DS, Hwang Y, Bae K, Chang KY, Lee WJ. Role of follicular dendritic cells in the apoptosis of germinal center B cells. Immunol Lett. 2000; 72(2):107-111.
• 12. Junqueira LC, Carneiro J, Kelley RO: Basic Histology, 8th Ed. Çeviri Ed: Prof. Dr. Yener Aytekin.Temel Histoloji, Barış Kitabevi, İstanbul, 1998: 252
• 13. Kapasi ZF, Qin D, Kerr WG, Kosco-Vilbois MH, Shultz LD, Tew jg, Szakal AK. Follicular dendritic cell (FDC) precusors in primary lymphoid tissues. The Journal of İmmunology 1998; 160:1078-1084.
• 14. Kinet-Denoel C, Heinen E, Radoux D, Simar LJ. Follicular dendritic cells in lymph nodes after x-irradiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1982; 42(2): 121-30.
• 15. Klaus GG, Humphrey JH. The generation of memory cells. I. The role of C3 in the generation of B memory cells. Immunology. 1977; 33(1): 31-40.
• 16. Knight SC, Stagg AJ. Antigen-presenting cell types. Current Opinion in Immunology 1993; 5: 374-382
• 17. McGee JOD, Isaacson PG, Wright NA. Oxford Textbook of Patology. 1st Ed. Oxford University Press, Oxford, 1992: 1746-1747.
• 18. Nossal GJ, Abbot A, Mitchell J, Lummus Z. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med. 1968; 127(2): 277-90.
• 19. Orui H, Yamakawa M, Imai Y. Proliferation and apoptosis of follicular lymphocytes: Relationship to follicular dendritic cell- associated clusters. Immunology 1997; 90(4): 489-495.
• 20. Park CS, Choi YS. How do follicular dendritic cells interact intimately with B cells in the germinal centre? Immunology 2005; 114(1): 2-10
• 21. Park CS, Yoon SO, Armitage RJ, Choi YS. Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form. J Immunol. 2004; 173(11): 6676-6683.
• 22. Parwaresch MR, Radzun HJ, Feller AC, Peters KP, Hansmann ML. Peroxidase-positive mononuclear leukocytes as possible precursors of human dendritic reticulum cells. J Immunol. 1983; 131: 2719.
• 23. Parwaresch MR, Radzun HJ, Hansmann ML, Peters KP. Monoclonal antibody Ki-M4 specifically recognizes human dendritic reticulum cells (follicular dendritic cells) and their possible precursor in blood. Blood. 1983; 62(3): 585-590.
• 24. Petrasch S, Kosco M, Schmitz J, Wacker HH, Brittinger G. Follicular dendritic cells in non-Hodgkin-lymphoma express adhesion molecules complementary to ligands on neoplastic B-cells. Br J Haematol. 1992; 82(4): 695-700.
• 25. Pinchuk G. Schaum’s Outline of Immunology. McGraw-Hill Professional, Blacklick, OH, 2001: 21.
• 26. Radoux D,Heinen E, Kinet-Denoel C, Tihange E, Simar L. Precise localization of antigens on follicular dendritic cells. Cell Tissue Res. 1984; 235(2): 267-74.
• 27. Schnizlein CT, Kosco MH, Szakal AK, Tew JG. Follicular dendritic cells in suspension: identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity. J Immunol.1985; 134(3): 1360-1368.
• 28. Schriever F, Freeman G, Nadler LM. Follicular dendritic cells contain a unique gene repertoire demonstrated by single-cell polymerase chain reaction. Blood 1991; 77:787-791.
• 29. Spiegel H, Herbst H, Niedobitek G, Foss HD, Stein H. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am J Pathol 1992; 140: 15-22
• 30. Szakal AK, Holmes KL, Tew JG. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. J Immunol. 1983; 131(4): 1714-1727.
• 31. Szakal AK, Kosco MH, Tew JG. A novel in vivo follicular dendritic cell-dependent iccosome-mediated mechanism for delivery of antigen to antigen proccessing cells. The Journal of Immunology 1988; 140: 341-353.
• 32. Tsunoda R, Bosseloir A, Onozaki K, Heinen E, Miyake K, Okamura H, Suzuki K,. Fujita T, Simar LJ, Sugai N. Human follicular dendritic cells in vitro and follicular dendritic-cell-like cells. Cell Tissue Res 1997; 288(2): 381-389
• 33. Tsunoda R, Nakayama M, Heinen E, Miyake K, Suzuki K, Sugai N, Kojima M. Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro. Virchows Arch B Cell Pathol Incl Mol Pathol. 1992; 62(2): 69-78.
• 34. Villena A, Zapata A, Rivera-pomar JM, Barrutia MG, Fonfria J. Structure of the non-lymphoid cells during the postnatal development of the rat lymph nodes, fibroblastic reticulum cells and interdigitating cells. Cell Tissue Res 1983; 229: 219-232.
• 35. Young B, Heat JN. Wheather’s Functional Histology. 4th Ed. Churchill Livingstone, Edinburg, 2000: 210