FOLİKÜLER DENDRİTİK HÜCRELER

Yıl 2006, Cilt: 4 Sayı: 2, 103 - 107, 30.03.2006

Dürrin Özlem Dabak Fatih Sönmez

Öz

Foliküler
dendritik hücre (FDH)’ler  lenf
düğümleri, dalak ve tonsillalardaki lenf foliküllerinde bulunurlar. Antijen
sunan bu hücreler komşu lenfoid hücrelerin arasına uzanan çok sayıda
sitoplazmik uzantılar (dendrit) ile karekterizedirler. FDH’ler germinal
merkez  mikroçevresinin bir anahtar
hücresel kompenenti olarak bi-linmektedir. Bu hücreler antijen antikor
kompleksini elde edip korur, hafıza B hücrelerini uyarabilir ve sonra daha
ileri T hücre aktivitesini uyarabilirler. Antijen, yerleştiği FDH’ler üzerinde
uzun zaman kalır ve bu özel-lik bazı enfeksiyon hastalıkları için çok
önemlidir. Bu derlemede FDH’ler geniş bir bakış açısından incelen-mişlerdir.

Anahtar Kelimeler

Foliküler Dendritik Hücreler, Antijen Sunan Hücreler, Antijenik Uyarım

Kaynakça

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