Aloe Vera Yüklü Kitosan/Fibroin Filmlerin Hazırlanması, Karakterizasyonu ve İlaç Salım Özelliklerinin Araştırılması

Öz

Bu çalışmada ilaç taşıyıcı özelliğe sahip, biyopolimer esaslı kitosan /ipek fibroin/aloe vera içeren filmler hazırlanmıştır. Bu amaçla öncelikle ham ipekten fibroin proteini saflaştırılarak ayrılmıştır. Daha sonra çözeltiden döküm yöntemiyle aloe vera katkılı fibroin/kitosan filmleri hazırlanmış ve SEM, FTIR ve TGA teknikleriyle hem yüzey, hem yapısal hem de ısıl davranışları karakterize edilmiştir. Ayrıca hazırlanan harman polimer filmlerine katılan antibiyotiğin salım şartları belirlenmiştir. Maksimum ilaç salımı %75 kitosan içeriğine sahip FK3 filminde gözlenmiştir. Ayrıca polimer filmlerinin pH 2 de en yüksek ilaç salımı sergilediği ve pH arttıkça salımın azaldığı belirlenmiştir.

Anahtar Kelimeler

• Fibroin
• Kitosan
• Aloevera
• İlaç Salım

Preparation, Characterization and Investigation of Drug Release Properties of Aloe Vera Loaded Chitosan/Fibroin Films

Öz

In this study, biopolymer-based chitosan/silk fibroin/aloe vera-based films with drug carrier properties were prepared. For this purpose, firstly, fibroin protein from raw silk was purified and separated. Then, aloe vera-doped fibroin/chitosan films were prepared by solution casting method and their surface, structural and thermal behaviors were characterized using SEM, FTIR and TGA techniques. Additionally, the release conditions of the antibiotic added to the prepared blend polymer films were determined. Maximum drug release was observed in FK3 film with 75% chitosan content. It was also determined that polymer films exhibited the highest drug release at pH 2 and that the release decreased as pH increased.

Anahtar Kelimeler

• Fibroin
• Chitosan
• Aloe vera
• Drug Release

Kaynakça

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