Araştırma Makalesi
BibTex RIS Kaynak Göster

Elit Türk Sporcularında Anjiotensin Dönüştürücü Enzim (I / D) Polimorfizmi ile Sportif Performans Arasındaki İlişkinin İncelenmesi

Yıl 2018, Cilt: 3 Sayı: 4, 122 - 137, 28.12.2018
https://doi.org/10.31680/gaunjss.476196

Öz

Anjiotensin dönüştürücü
enzim fiziksel aktivite ile ilişkili önemli bir gendir. ACE geni intron 16’da
plazma ve dokularda ACE düzeylerini belirleyen bir polimorfizme (I/D) sahiptir.
Bu çalışmanın amacı elit Türk sporcularından  (dayanıklılık ve kuvvet sporcusu) oluşan bir
populasyonda (kayak, hentbol, voleybol, güreş) ACE geni I/D polimorfizmi ile
spor performansı arasında bir ilişki olup olmadığını belirlemektir. Periferal
kandan DNA elde edildi ve her bir bireyin ACE genotip dağılımı polimeraz zincir
reaksiyonu yöntemiyle belirlendi. 114 elit Türk sporcusu dayanıklılık (18) ve
kuvvet sporcuları (96) olarak iki gruba ayrıldı. Sporcuların ACE geni genotip
ve alel frekansları; 114 elit sporcu, her bir sporcu grubu,  dayanıklılık sporcuları ve kuvvet sporcuları
olmak üzere dört ayrı katagoride kontrol grubu ile karşılaştırıldı. Ayrıca her
bir spor grubundaki sporcular ile dayanıklılık ve kuvvet sporcuları birbirleriyle
Ki-kare and Fisher exact testi ile karşılaştırıldı.
Elit Türk sporcu ve
kontrol grubu arasında ve diğer kategoriler arasında yapılan karşılaştırmalarda
ACE geni genotip dağılımı ve alel frekanslarında istatistiksel olarak anlamlı
bir fark tespit edilmedi (p > 0.05).

Kaynakça

  • Alvarez, R., Terrados, N., Ortolano, R., Iglesias-Cubero, G., Reguero, J.R., Batalla, A. ve ark. (2000). Genetic variation in the renin-angiotensin system and athletic performance. Eur J Appl Physiol., 82(1-2), 117-120.Ahmetov, I.I. ve Fedotovskaya, O.N. (2015). Current Progress in Sports Genomics. Adv Clin Chem., 70, 247-314.
  • Ahmetov, I.I. ve Rogozkin, V.A. (2009). Genes, athlete status and training -- An overview. Med Sport Sci., 54, 43-71.
  • Ash, G.I., Scott, R.A., Deason, M., Dawson, T.A., Wolde, B., Bekele, Z. ve ark. (2011). No association between ACE gene variation and endurance athlete status in Ethiopians. Med Sci Sports Exerc., 43(4), 590-597.
  • Bayraktar, B. ve Kurtoğlu, M. (2009). Sporda performans, etkili faktörler, değerlendirilmesi ve artırılması. Klinik Gelişim, 22(1), 16-24.
  • Bray, M.S., Hagberg, J.M., Perusse, L., Rankinen, T., Roth, S.M., Wolfarth, B. ve ark. (2009). The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc., 41, 35-73.
  • Brewster, U.C. ve Perazella, M.A. (2004). The renin-angiotensin-aldosterone system and the kidney: Effects on kidney disease. Am J Med., 116, 263-72.
  • Cieszczyk, P., Krupecki, K., Maciejewska, A., Sawczuk, M. (2009). The angiotensin converting enzyme gene I/D polymorphism in polish rowers. Int J Sports Med., 30, 624-627.
  • Collins, M., Xenophontos, S.L., Cariolou, M.A., Mokone, G.G., Hudson, D.E., Anastasiades, L. ve ark. (2004). The ACE gene and endurance performance during the South African Ironman Triathlons. Med Sci Sports Exerc., 36, 1314-1320.
  • Costa, A.M., Silva, A.J., Garrido, N., Louro, H., Marinho, D.A., Cardoso Marques, M. ve ark. (2009). Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes. J Sports Sci Med., 8, 410-418.
  • Costa, A.M., Silva, A.J., Garrido, N.D., Louro, H., de Oliveira, R.J., Breitenfeld, L. (2009). Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol., 106, 785-790.
  • De Moor, M.H., Spector, T.D., Cherkas, L.F., Falchi, M., Hottenga, J.J., Boomsma, D.I. ve ark. (2007). Genome wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet.,10(6), 812-820.
  • Drozdovska, S.B., Dosenko, V.E., Ahmetov, I.I., Ilyin, V.N. (2013). The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport., 30(3), 163-167
  • Durmic, T.S., Zdravkovic, M.D., Djelic, M.N., Gavrilovic, T.D., Djordjevic Saranovic, S.A. Plavsic, J.N. ve ark. (2017). Polymorphisms in ACE and ACTN3 genes and blood pressure response to acute exercise in elite male athletes from Serbia. Tohoku J Exp Med., 243(4), 311-320.
  • Eider, J., Cieszczyk, P., Ficek, K., Leonska-Duniec, A., Sawczuk, M, Maciejewska-Karlowska, A. ve ark. (2013). The association between D allele of the ACE gene and power performance in Polish elite athletes. Association entre l’allèle D du gène ACE et les performances en force chezdes sportifs polonais de haut niveau. Science & Sports, 28, 325-330.
  • Folland, J., Leach, B., Little, T., Hawker, K., Myerson, S., Montgomery, H. ve ark. (2000). Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol., 85, 575-579.
  • Gayagay, G., Yu, B., Hambly, B., Boston, T., Hahn, A., Celermajer, D.S. ve ark. (1998). Elite endurance athletes and the ACE I allele: the role of genes in athletic performance. Hum Genet., 103(1), 48-50.
  • Gunel, T., Gumusoglu, E., Hosseini, M.K., Yilmazyildirim, E., Dolekcap, I., Aydınlı, K. (2014). Effect of angiotensin I-converting enzyme and α-actinin-3 gene polymorphisms on sport performance Mol Med Rep., 9, 1422-1426.
  • Günay, M., Ülküer, K.M., Çelenk, Ç., Bezci, Ş., Gökdemir, K., Gevat, C., Kesici, T. (2010). Angiotensin-converting enzyme polymorphism in elite taekwondo athletes of Turkish and Azerbaijan taekwondo teams. Ovidius University Annals. Series Physical Education and Sport / Science, Movement and Health, 10(2), 165-168.
  • Jones, A., Montgomery, H.E., Woods, D.R. (2002). Human performance: A role for the ACE genotype? Exerc Sport Sci Rev., 30,184-190.
  • Kikuchi, N., Min, S.K., Ueda, D., Igawa, S., Nakazato, K. (2012). Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res., 26(12), 3275-3280.
  • Kim, C.H., Cho, J.Y., Jeon, J.Y., Koh, Y.G., Kim, Y.M., Kim, H.J. ve ark. (2010). ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med., 31(1), 65-71.
  • Lindpaintner, K., Pfeffer, M.A., Kreutz, R., Stampfer, M.J., Grodstein, F., LaMotte, F. ve ark. (1995). A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med., 332, 706-711.
  • Lucia, A., Gomez-Gallego, F., Chicharro, J., Hoyos, J., Celaya, K., Cordova, A. (2005). Is there no association between ACE and CKMM polymorphisms and cycling performance status during 3-weeks races? Int J Sports Med., 26(6), 442-447.
  • Ma, F., Yang, Y., Li, X., Zhou, F., Gao, C., Li, M. ve ark. (2013). The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PLoS One, 8, e54685.
  • Macarthur, D.G. ve North, K.N. (2005). Genes and human elite athletic performance. Hum Genet., 116, 331-339.
  • Mattei, M.G., Hubert, C., Alhenc-Gelas, F., Roeckel, N., Corvol, P., Soubrier F. (1989). Angiotensin I converting enzyme gene is on chromosome 17. Cytogenet Cell Genet., 51, 1041-1045.
  • Min, S.K., Takahashi, K., Ishigami, H., Hiranuma, K., Mizuno, M., Ishii, T., ve ark. (2009). Is there a gender difference between ACE gene and race distance? Appl Physiol Nutr Metab., 34(5), 926-932.
  • Montgomery, H.E., Marshall, R., Hemingway, H., Myerson, S., Clarkson, P., Dollery, C., ve ark. (1998). Human gene for physical performance. Nature, 393(6682), 221-222.
  • Moran, C.N., Vassilopoulos, C., Tsiokanos, A., Jamurtas, A.Z., Bailey, M.E., Montgomery, H.E. ve ark. (2006). The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. Eur J Hum Genet., 14, 332-339.
  • Murphey, L.J., Gainer, J.V., Vaughan, D.E., Brown, N.J. (2000). Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation, 102, 829-632.
  • Myerson, S., Hemingway, H., Budget, R., Martin, J., Humphries, S., Montgomery, H. (1999). Human angiotensin I–converting enzyme gene and endurance performance. J Appl Physiol., 87(4), 1313-1316.
  • Nagashima, J., Musha, H., Takada, H., Awaya, T., Oba, H., Mori, N. ve ark. (2000). Influence of angiotensin-converting enzyme gene polymorphism on development of athlete's heart. Clin Cardiol., 23, 621-624.
  • Nazarov, I.B., Woods, D.R., Montgomery, H.E., Shneider, O.V., Kazakov, V.I., Tomilin, N.V. ve ark. (2001). The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet., 9, 797-801.
  • Oh, S.D. (2007). The distribution of I/D polymorphism in the ACE gene among Korean male elite athletes. J Sports Med Phys Fitness., 47(2), 250-254.
  • Oktem, F., Sirin, A., Bilge, I., Emre, S., Ağaçhan, B., Ispir, T. (2004). ACE I/D gene polymorphism in primary FSGS and steroid-sensitive nephrotic syndrome. Pediatr Nephrol., 19, 384-389.
  • Orysiak, J., Zmijewski, P., Klusiewicz, A., Kaliszewski, P., Malczewska-Lenczowska, J., Gajewski, J. ve ark. (2013). The association between ace gene variation and aerobic capacity in winter endurance disciplines. Biol Sport., 30(4), 249-253.
  • Ostrander, E.A., Huson, H.J. ve Ostrander, G.K. (2009). Genetics of athletic performance. Annu Rev Genomics Hum Genet., 10, 407-429.
  • Papadimitriou, I.D., Papadopoulos, C., Kouvatsi, A., Triantaphyllidis, C. (2009). The ACE I/D polymorphism in elite Greek track and field athletes. J Sports Med Phys Fit., 49, 459-463.
  • Phillips, P.C. (2008). Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet., 9(11), 855-67.
  • Puthucheary, Z., Skipworth, J.R., Rawal, J., Loosemore, M., Van Someren, K., Montgomery, H.E. (2011). The ACE gene and human performance: 12 years on. Sports Med., 41(6), 433-448.
  • Rankinen, T., Wolfarth, B., Simoneau, J.A., Maier-Lenz, D., Rauramaa, R., Rivera, M.A. ve ark. (2000). No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol., 88(5), 1571-1575.
  • Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., Soubrier, F. (1990). An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Ciln Invest., 86(4), 1343-1346.
  • Rigat, B., Hubert, C., Corvol, P., Soubrier, F. (1992). PCR Detection of the Insertion/Deletion of the Human Angiotensin Converting Enzyme Gene (DCP 1) (Dipeptidyl Carboxypeptidase 1). Nucleic Acids Res., 20(6), 1433.
  • Sambrook, J., Fritsch, E.F., Maniatis, T. (1989). Molecular Cloning. Cold Spring Harbor, Cold Spring Harbor, NY, USA.
  • Scanavini, D., Bernardi, F., Castoldi, E., Conconi, F., Mazzoni, G. (2002). Increased frequency of the homozygous II ACE genotype in Italian Olympic endurance athletes. Eur J Hum Genet., 10(10), 576-577.
  • Scott, R.A., Irving, R., Irwin, L., Morrison, E., Charlton, V., Austin, K. ve ark. (2010). ACTN3 and ACE genotypes in elite Jamaican and US sprinters. Med Sci Sports Exerc., 42, 107-112.
  • Scott, R.A., Moran, C., Wilson, R.H., Onywera, V., Boit, M.K., Goodwin, W.H. ve ark. (2005). No association between Angiotensin Converting Enzyme (ACE) gene variation and endurance athlete status in Kenyans. Comp Biochem Physiol – Part A: Mol Integr Physiol., 141(2), 169-175.
  • Sercan, C., Eken, B.F., Erel, Ş., Ülgüt, D., Kapıcı, S., Ulucan, K. (2016). Spor genetiği ve ACE gen ilişkisi. İnönü Üniversitesi, Beden Eğitimi ve Spor Bilimleri Dergisi, 3(2), 26-34.
  • Shahmoradi, S., Ahmadalipour, A., Salehi, M. (2014). Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res., 3, 207.
  • Sonna, L.A., Sharp M.A., Knapik, J.J., Cullivan, M., Angel, K.C., Patton, J.F. ve ark. (2001). Angiotensin-converting enzyme genotype and physical performance during US Army basic training. J Appl Physiol., 91(3), 1355-1363.
  • Spriet, L.L. (2018). Nutritional and Environmental Influences on Athlete Health and Performance. Sports Med., 48(Suppl 1),1-2.
  • Süel, E. ve Pehlivan, A. (2015). Angiotensin dönüştürücü (converting) enzim (ACE) gen polimorfizminin elit basketbolcu ve voleybolcularda karşılaştırılması. Uluslararası Spor, Egzersiz ve Antrenman Bilimi Dergisi, 1(1), 40-50.
  • Taylor, R.R., Mamotte, C.D.S., Fallon, K., van Bockxmeer, F.M. (1999). Elite athletes and the gene for angiotensin-converting enzyme. J Appl Physiol., 87(3), 1035-1037.
  • Thomis, M.A., Huygens, W., Heuninckx, S., Chagnon, M., Maes, H.H., Claessens, A.L. ve ark. (2004). Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. Eur J Appl Physiol., 92(3), 267-274.
  • Tsianos, G., Sanders, J., Dhamrait, S., Humphries, S., Grant, S., Montgomery, H. (2004). The ACE gene insertion/deletion polymorphism and elite endurance swimming. Eur J Appl Physiol., 92, 360-362.
  • Turgut, G., Turgut, S., Genc, O., Atalay, A., Atalay E.O. (2004). The angiotensin converting enzyme I/D polymorphism in Turkish athletes and sedentary controls. Acta Medica (Hradec Kralove), 47(2), 133-136.
  • Williams, A.G., Rayson, M.P., Jubb, M., World, M., Woods, D.R., Hayward M. ve ark. (2000). Physiology: The ACE gene and muscle performance. Nature, 403(6770), 614.
  • Woods, D., Hickman, M., Jamshidi, Y., Brull, D., Vassiliou, V., Jones, A. ve ark. (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet., 108, 230-232.
  • Woods, D.R., World, M., Rayson, M.P., Williams, A.G., Jubb, M., Jamshidi, Y. ve ark. (2002). Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training. Eur J Appl Physiol., 86(3), 240-244.
  • Zhang, B., Tanaka, H., Shono, N., Miura, S., Kiyonaga, A., Shindo, M. ve ark. (2003). The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet., 63(2), 139-144.
Toplam 60 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Spor Hekimliği
Bölüm Hareket ve Antrenman Bilimleri
Yazarlar

Melahat Kurtuluş

Mehmet Günay

Ebru Çetin

Çağrı Çelenk

İbrahim Cicioğlu

Ebru Alp Bu kişi benim

Meral Yirmibeş Karaoğuz Bu kişi benim

Tahsin Kesici Bu kişi benim

Yayımlanma Tarihi 28 Aralık 2018
Gönderilme Tarihi 31 Ekim 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 3 Sayı: 4

Kaynak Göster

APA Kurtuluş, M., Günay, M., Çetin, E., Çelenk, Ç., vd. (2018). Elit Türk Sporcularında Anjiotensin Dönüştürücü Enzim (I / D) Polimorfizmi ile Sportif Performans Arasındaki İlişkinin İncelenmesi. Gaziantep Üniversitesi Spor Bilimleri Dergisi, 3(4), 122-137. https://doi.org/10.31680/gaunjss.476196

ISSN: 2536-5339

Gaziantep Üniversitesi Spor Bilimleri Dergisi

16157

Bu dergi içerisinde yer alan eserler aksi belirtilmedikçe Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı ile lisanslanmıştır.