Egzersiz, İrisin ve Obezite

Yıl 2022, Cilt: 7 Sayı: 2, 137 - 152, 20.06.2022

Salih Öner , Yavuz Yasul

https://doi.org/10.31680/gaunjss.1119354

Öz

Gelişmiş ve gelişmekte olan ülkelerdeki şehir hayatının hareketsiz yaşamı, besinsel ürünlere kolay ulaşabilmeyi ve fas food kültürünü yaygınlaştırdığı görülmektedir. Yeni yaşam tarzı hem halk sağlığını tehdit etmekte hem de sistemik metabolik fonksiyon bozukluklarına kılavuzluk ederek obezite gibi hastalıkların yaygınlaşmasına neden olmaktadır. Bu yönüyle obezite ile birlikte adipoz dokudaki doku disfoksiyonu adipokinlerin salgılanması ve yapımında birçok komplikasyona neden olmakta ve yaşam koşullarındaki kaliteyi bozarak mortalite oranını arttırmaktadır. Dolayısıyla bir kartopu gibi büyüyen bu halk sağlığı problemine engel olmak veya ortadan kaldırmak için bilim insanları yeni bir yön bulma çabası içerisindedir. Bu çaba miyokin ailesinin adipokinlerin etkilerini dengelediği ve bunlara karşı koyabileceği şeklindeki keşif ile bilim insanlarını umutlandırmış olsa da bu yönde güçlü bir yargı ortaya koyabilmek için daha fazla idman yapılması şeklindeki gerçekte karşımızda durmaktadır. Özellikle son zamanlarda kas hücrelerindeki miyokinlerin ve miyokin ailesinin bir üyesi olan irisinin beyaz yağ dokusunu esmerleştirmesi, enerji harcanması, glukoz toleransındaki rolü, metabolik işlerle bağlantısı ve vücut kompozisyonu arasındaki ilişkinin keşfi bu yönde çalışan bilim insanlarını heyecanlandırmış ve egzersizin hem irisin hem de obezite üzerinde etkisine yeni bir pencere açmıştır. Bu kapsamda egzersizin insanlar üzerindeki etkilerini anlamaya çalışan bilim insanları egzersiz ve irisin arasındaki ilişkinin yönü hakkında titrek bir ses tonuyla konuşurken egzersiz, irisin ve obezite arasındaki ilişki konusunda daha açık ve anlaşılır bir ifade bütünlüğü görmekteyiz. Dolayısıyla bu derleme egzersiz ile irisin arasındaki ilişkiyi güncel çalışmalara göre değerlendirmek ve egzersiz, irisin ve obezite etkileşimine yeni bir bakış açısı sunmayı amaçlamaktadır.

Anahtar Kelimeler

Egzersiz, İrisin, Obezite, Lipit Metabolizması, FNDC5

Kaynakça

• A.B. Crujeiras, M. Pardo, R.R. Arturo, S. Navas-Carretero, M.A. Zulet, J.A. Martinez, F.F. Casanueva (2014). Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am. J. Hum. Biol. 26, 198–207.
• A.E. Huerta, P.L. Prieto-Hontoria, M. Fernandez-Galilea, N. Sainz, M. Cuervo, J.A. Martinez, M.J. Moreno-Aliaga (2015). Circulating irisin and glucose metabolism in overweight/obese women: effects of alpha-lipoic acid and eicosapentaenoic acid. J. Physiol. Biochem. 71, 547–558.
• Akbulut, T. (2020). How Does an Intensive Exercise Training Changes Irisin and Heat Shock Protein 70 Levels in Trained Males?. International Journal of Applied Exercise Physiology, 9(3), 134-139.
• Archundia-Herrera C., Macias-Cervantes M., Ruiz-Muñoz B., Vargas-Ortiz K., Kornhauser C., PerezVazquez V (2017). Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetol. Metab. Syndr. 1-9:165–172.
• Arıkan, Ş. (2018). The effect of acute exercise and gender on the levels of irisin in elite athletes. Physical education of students, 22(6), 304-307.
• Arıkan, Ş., Revan, S., Balcı, Ş.S., Şahin, M. ve Serpek, B. (2018). Effect of training on plasma irisin, leptin and insulin levels. Int J Appl Exerc Physiol, 2, 1-8.
• Blonde, L.,Pencek, R. ve Macconell, L. (2015). Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes. Cardiovascular Diabetology, 14, 12.
• Bortoluzzi, S., Scannapieco, P., Cestaro, A., Danieli, G. A., & Schiaffino, S. (2006). Computational reconstruction of the human skeletal muscle secretome. PROTEINS: Structure, Function, and Bioinformatics, 62(3), 776-792.
• Boström, P. A., Graham, E. L., Georgiadi, A., & Ma, X. (2013). Impact of exercise on muscle and nonmuscle organs. IUBMB life, 65(10),845-850.
• Briken, S., Rosenkranz, S. C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Gold, S. M. (2016). Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of neuroimmunology, 299, 53-58.
• Buscemi, S., Corleo, D., Buscemi, C., & Giordano, C. (2018). Does iris (in) bring bad news or good news?. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity, 23(4), 431-442.
• C. Gutierrez-Repiso, S. Garcia-Serrano, F. Rodriguez-Pacheco, E. Garcia-Escobar, J.J. Haro-Mora, J. Garcia-Arnes, S. Valdes, M. Gonzalo, F. Soriguer, F.J. Moreno-Ruiz, A. Rodriguez- Canete, A. Martinez-Ferriz, J.S. Santoyo, V. Perez-Valero, E. Garcia-Fuentes 2014, FNDC5 could be regulated by leptin in adipose tissue. Eur. J. Clin. Invest. 44, 918–925.
• Castillo-Quan JI (2011). Parkin control: regulation of PGC-1α through PARIS in Parkinson's disease. Dis Model Mech. 4:427-429.
• D. Loffler, U. Muller, K. Scheuermann, D. Friebe, J. Gesing, J. Bielitz, S. Erbs, K. Landgraf, I.V. Wagner, W. Kiess, A. Korner (2015). Serum irisin levels are regulated by acute strenuous exercise. J. Clin. Endocrinol. Metab. 100, 1289–1299.
• De Oliveira, M., Mathias, L. S., Rodrigues, B. M., Mariani, B. G., Graceli, J. B., De Sibio, M. T., Nogueira, C. R. (2020). The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells. Molecular and cellular endocrinology, 506, 110744.
• Dünnwald T., Melmer A., Gatterer H., Salzmann K., Ebenbichler C., Burtscher M., Schobersberger W., Grander W (2019). Tip 2 diyabetli hastalarda plazma irisin konsantrasyonları üzerine kısa süreli yüksek yoğunluklu eğitim . Int. J. Spor Med. 40 :158-164.
• Elsen, M., Raschke, S. ve Eckel, J. (2014). Browning of white fat: does irisin play a role in humans? J Endocrinol, 222, 25-38.
• Erdogan, R., Tel, M., Cinar, V., & Pala, R. (2021). Effect of Regular Exercise on Fat Metabolism in Rats Fed on Zinc Picolinate Supplemented Diet. Pakistan Journal of Zoology, 53(6).
• Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S. (2013). Irisin and exercise training in humans – results from a randomized controlled training trial. Bmc Med, 11, 235.
• Inoue, K., Fujie, S., Hasegawa, N., Horii, N., Uchida, M., Iemitsu, K., Sanada, K., Hamaoka, T., & Iemitsu, M. (2020). Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 45(7), 715–722.
• J. Huang, S. Wang, F. Xu, D. Wang, H. Yin, Q. Lai, J. Liao, X. Hou, M. Hu (2017). Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study. e3669
• J. Zhang, P. Valverde, X. Zhu, D. Murray, Y. Wu, L. Yu, H. Jiang, M.M. Dard, J. Huang, Z. Xu, Q. Tu, J. Chen (2017). Exerciseinduced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism. Bone Res. 5, 16056.
• J.I. Castillo-Quan (2012). From white to brown fat through the PGC1alpha-dependent myokine irisin: implications for diabetes and obesity. Dis. Model Mech. 5, 293–295. J.M. Moreno-Navarrete, F. Ortega, M. Serrano, E. Guerra, G. Pardo, F. Tinahones, W. Ricart, J.M. Fernandez-Real (2014). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J. Clin. Endocrinol. Metab. 98, E769–E778.
• J.Y. Huh, F. Dincer, E. Mesfum, C.S. (2014). Mantzoros, Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. Int. J. Obes. 38, 1538–1544.
• J.Y. Huh, G. Panagiotou, V. Mougios, M. Brinkoetter, M.T. Vamvini, B.E. Schneider, C.S. Mantzoros (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61, 1725–1738.
• Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM. Detection and quantitation of circulating human irisin by tandem mass spectrometry. Cell Metab 2015;22:734–740.
• Jia, J., Yu, F., Wei, W. P., Yang, P., Zhang, R., Sheng, Y., & Shi, Y. Q. (2019). Relationship between circulating irisin levels and overweight/obesity: A meta-analysis. World journal of clinical cases, 7(12), 1444–1455.
• Kabasacalis, A., Nikolaidis, S.,Tsalis, G., Christoulas, K. ve Mougios, V. (2019). Effects of sprint interval exercise dose and sex on circulating irisin and redox status markers in adolescent swimmers. Journal of Sports Sciences, 37(7), 827-832.
• Karampatsou, S. I., Genitsaridi, S. M., Michos, A., Kourkouni, E., Kourlaba, G., Kassari, P., Manios, Y., & Charmandari, E. (2021). The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity. Nutrients, 13(4), 1274.
• Khalafi, M., Shabkhız, F., Alamdarı, K.A. ve Bakhtıyarı, A. (2016). Irisin response to two types of exercise training in type 2 diabetic male rats. Arak Med University J, 19, 37-45.
• Khodadadi H., Rajabi H., Seyyed Reza Attarzadeh S.R., Abbasian S (2014). The efect of high intensity interval training (HIIT) and pilates on levels of irisin and insulin resistance in overweight women. Iran. J. Endocrinol. Metab. 16:190–196.
• Küçük, H. (2018). The effect of aerobic and anaerobic capacity on serum irisin, leptin, ghrelin levels. Unpublished Doctoral Thesis, Ondokuz Mayıs University Health Sciences Institute, Samsun.
• Liu, R., Zhang, Q., Peng, N., Xu, S., Zhang, M., Hu, Y., Chen, Z., Tang, K., He, X., Li, Y., & Shi, L. (2021). Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population. BMC cardiovascular disorders, 21(1), 570.
• Mai, S., Grugni, G., Mele, C., Vietti, R., Vigna, L., Sartorio, A., Aimaretti, G., Scacchi, M., & Marzullo, P. (2020). Irisin levels in genetic and essential obesity: clues for a potential dual role. Scientific reports, 10(1), 1020.
• Mohr, T., Andersen, J. L., Biering-Sørensen, F., Galbo, H., Bangsbo, J., Wagner, A., & Kjaer, M. (1997). Long term adaptation to electrically induced cycle training in severe spinal cord injured individuals. Spinal cord, 35(1), 1-16.
• Murawska-Cialowicz, E., Wolanski, P., Zuwala-Jagiello, J., Feito, Y., Petr, M., Kokstejn, J., Stastny, P., & Goliński, D. (2020). Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men. International journal of environmental research and public health, 17(10), 3589.
• N. Perakakis, G.A. Triantafyllou, J.M. Fernandez-Real, J.Y. Huh, K.H. Park, J. Seufert, C.S (2017). Mantzoros, Physiology and role of irisin in glucose homeostasis. Nat. Rev. Endocrinol. 13, 324–337.
• P. Bostrom, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, J.C. Lo, K.A. Rasbach, E.A. Bostrom, J.H. Choi, J.Z. Long, S. Kajimura, M.C. Zingaretti, B.F. Vind, H. Tu, S. Cinti, K. Hojlund, S.P. Gygi, B.M. Spiegelman (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463–468.
• P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, B.M (1998). Spiegelman, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829–839. Palacios‐González, B., Vadillo‐Ortega, F., Polo‐Oteyza, E., Sánchez, T., Ancira‐Moreno, M., Romero‐Hidalgo, S., ... & Antuna‐Puente, B. (2015). Irisin levels before and after physical activity among school‐age children with different BMI: A direct relation with leptin. Obesity, 23(4), 729-732.
• Pedersen, B., Febbraio, M (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8, 457–465.
• Polyzos S.A., Anastasilakis, A.D., Efstathiadou, Z.A., Makras, P., Perakakis, N., Kountouras, J., Mantzoros, C.S. (2018). Irisin in metabolic diseases. Endocrine, 2, 260-74
• Polyzos S.A., J. Kountouras, K. Shields, C.S. Mantzoros (2013). Irisin: a renaissance in metabolism? Metabolism 62, 1037–1044.
• Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS (2014). Irisin in patients with nonalcoholic fatty liver disease. Metabolism. Feb;63(2), 207-17.
• Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Pardo, M. (2013). FNDC5/irisin is not only a myokine but also an adipokine. PloS one, 8(4), 60563.
• Qian, S. W., Tang, Y., Li, X., Liu, Y., Zhang, Y. Y., Huang, H. Y., ... & Tang, Q. Q. (2013). BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proceedings of the National Academy of Sciences, 110(9), 798-807.
• Rajabi A, Siahkouhian M, Akbarnejad A,Yari M (2018). Comparison between the effects of two different frequencies of aerobic exercise with the same volume and detraining period on the levels of irisin hormone, lipid profiles, and insulin resistance index in obese women with type 2 diabetes. Journal of Birjand University of Medical Sciences, 24(4), 291-305.
• Rashid, F. A., Abbas, H. J., Naser, N. A., & Addai Ali, H. (2020). Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men. The Scientific World Journal, 2020.
• S. Gao, F. Li, H. Li, Y. Huang, Y. Liu, Y. Chen. (2016). Effects and molecular mechanism of GST-Irisin on lipolysis and autocrine function in 3T3-L1 adipocytes. PLoS ONE 11, 1.
• Sengupta, P., Dutta, S., Karkada, I. R., Akhigbe, R. E., & Chinni, S. V. (2021). Irisin, energy homeostasis and male reproduction. Frontiers in Physiology, 12.
• Shim, Y. S., Kang, M. J., Yang, S., & Hwang, I. T. (2017). Irisin is a biomarker for metabolic syndrome in prepubertal children. Endocrine journal, EJ17-0260.
• Tibana, R. A., da Cunha Nascimento, D., Frade de Souza, N. M., De Souza, V. C., de Sousa Neto, I. V., Voltarelli, F. A., ... & Prestes, J. (2017). Irisin levels are not associated to resistance training-induced alterations in body mass composition in older untrained women with and without obesity. The journal of nutrition, health & aging, 21(3), 241-246.
• Timmons, J.A., Baar, K., Davidsen, P.K. ve Atherton, P.J. (2012). Is irisin a human exercise gene?. Nature, 488, 10.
• Uysal, N., Yuksel, O., Kizildag, S., Yuce, Z., Gumus, H., Karakilic, A., ... & Ates, M. (2018). Regular aerobic exercise correlates with reduced anxiety and incresed levels of irisin in brain and white adipose tissue. Neuroscience Letters, 676, 92-97.
• X.Q. Xiong, D. Chen, H.J. Sun, L. Ding, J.J. Wang, Q. Chen, Y. H. Li, Y.B. Zhou, Y. Han, F. Zhang, X.Y. Gao, Y.M. Kang, G. Q. Zhu. (2015). FNDC5 overexpression and irisin ameliorate glucose/ lipid metabolic derangements and enhance lipolysis in obesity. Biochim. Biophys. Acta 1852, 1867–1875.
• Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., ... & Tang, D. (2014). Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes, 63(2), 514-525.
• Yuksel Ozgor, B., Demiral, I., Zeybek, U., Celik, F., Buyru, F., Yeh, J., & Bastu, E. (2020). Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity. Metabolic syndrome and related disorders, 18(3), 141–145.
• Zhang, G., Sun, Q., & Liu, C. (2016). Influencing factors of thermogenic adipose tissue activity. Frontiers in physiology, 7, 29.
• Zhao, J., Su, Z., Qu, C. ve Dong, Y. (2017). Effects of 12 weeks resistance training on serum irisin in older male adults front. Physiol, 8,171.