Dental kök hücrelerin rejeneratif medikal tedavideki yeri

Yıl 2015, , 98 - 105, 21.04.2015

Özlem Özer Yücel Sibel Gültekin

https://doi.org/10.17214/aot.10464

Öz

Kök hücreler birçok farklı hücre tipine farklılaşabilme potansiyeline sahip, sınırsız bölünebilme ve yenilenebilme kapasitesi olan hücrelerdir. Kök hücre bazlı tedaviler ve doku mühendisliği, nörodejeneratif hastalıklar, kalp hastalıkları, diabet, ve kanser dahil birçok hastalığın tedavi edilebilmesi için umut vaad etmektedir. Oral bölgeden izole edilen dental kök hücrelerin kemik iliği stroma hücreleri gibi diğer kök hücre kaynaklarına göre daha az invaziv yöntemlerle elde edilebildikleri ve benzer farklılaşma yetenekleri olduğu gösterilmiştir. Bu derleme, kök hücrelerin biyolojik özelliklerini, farklı kök hücre tiplerini, farklılaşma potansiyellerini ve kök hücre kaynaklı rejeneratif medikal tedavi ve doku mühendisliğindeki güncel gelişmeleri özetlemektedir.

Anahtar Kelimeler

Kök hücre, doku mühendisliği, rejeneratif tıp

Dental stem cells in regenerative medicine

Öz

Stem cells have remarkable potential to develop into many different cell types with unlimited dividing and self-renewal capacity. Stem cell-based therapies and tissue engineering are considered to be promising for treatment of many diseases including neurodegenerative diseases, heart diseases, diabetes, cancer, etc. Dental stem cells isolated from the oral niches are reported to have similar differentiation capabilities and less invasive isolation methods compared to other stem cells like bone-marrow stem cells. This review outlines the biological properties and different types of stem cells; differentiation potentials and the recent progress of stem cells used in regenerative medicine and tissue engineering.

Anahtar Kelimeler

Stem cell, tissue engineering, regenerative medicine

Kaynakça

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