Dental kök hücrelerin rejeneratif medikal tedavideki yeri

Yıl 2015, Cilt: 32 Sayı: 2, 98 - 105, 21.04.2015

Özlem Özer Yücel Sibel Gültekin

https://doi.org/10.17214/aot.10464

Öz

Kök hücreler birçok farklı hücre tipine farklılaşabilme potansiyeline sahip, sınırsız bölünebilme ve yenilenebilme kapasitesi olan hücrelerdir. Kök hücre bazlı tedaviler ve doku mühendisliği, nörodejeneratif hastalıklar, kalp hastalıkları, diabet, ve kanser dahil birçok hastalığın tedavi edilebilmesi için umut vaad etmektedir. Oral bölgeden izole edilen dental kök hücrelerin kemik iliği stroma hücreleri gibi diğer kök hücre kaynaklarına göre daha az invaziv yöntemlerle elde edilebildikleri ve benzer farklılaşma yetenekleri olduğu gösterilmiştir. Bu derleme, kök hücrelerin biyolojik özelliklerini, farklı kök hücre tiplerini, farklılaşma potansiyellerini ve kök hücre kaynaklı rejeneratif medikal tedavi ve doku mühendisliğindeki güncel gelişmeleri özetlemektedir.

Anahtar Kelimeler

Kök hücre, doku mühendisliği, rejeneratif tıp

Dental stem cells in regenerative medicine

Öz

Stem cells have remarkable potential to develop into many different cell types with unlimited dividing and self-renewal capacity. Stem cell-based therapies and tissue engineering are considered to be promising for treatment of many diseases including neurodegenerative diseases, heart diseases, diabetes, cancer, etc. Dental stem cells isolated from the oral niches are reported to have similar differentiation capabilities and less invasive isolation methods compared to other stem cells like bone-marrow stem cells. This review outlines the biological properties and different types of stem cells; differentiation potentials and the recent progress of stem cells used in regenerative medicine and tissue engineering.

Anahtar Kelimeler

Stem cell, tissue engineering, regenerative medicine

Kaynakça

• NIH Stem Cell Information Home Page. In Stem Cell Information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2013 [cited Tuesday, May 14, 2013] Available at <http://stemcells.nih.gov/Pages/Default.aspx>)
• Regenerative medicine glossary. Regen Med 2009;4:S1-88.
• Asano T, Sasaki K, Kitano Y, Terao K, Hanazono Y. In vivo tumor formation from primate embryonic stem cells. Methods Mol Biol 2006;329:459-67.
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
• Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
• Do JT, Schöler HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 2004;22:941-9.
• Pralong D, Trounson AO, Verma PJ. Cell fusion for reprogramming pluripotency: toward elimination of the pluripotent genome. Stem Cell Rev 2006;2:331-40.
• Pralong D, Verma PJ. Techniques for nuclear transfer to mouse embryonic stem cells. Methods Mol Biol 2006;348:269-84.
• Ho PJ, Yen ML, Lin JD, Chen LS, Hu HI, Yeh CK, et al. Endogenous KLF4 expression in human fetal endothelial cells allows for reprogramming to pluripotency with just OCT3/4 and SOX2--brief report. Arterioscler Thromb Vasc Biol 2010;30:1905-7.
• Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2:3081-9.
• Kaufman MH, Robertson EJ, Handyside AH, Evans MJ. Establishment of pluripotential cell lines from haploid mouse embryos. J Embryol Exp Morphol 1983;73:249-61.
• Thomson JA, Itskovitz-Eldor J, Shapiro SS,Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
• Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, et al. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 2004;350:1353-6.
• Thomson JA, Marshall VS, Trojanowski JQ. Neural differentiation of rhesus embryonic stem cells. APMIS 1998;106:149-56.
• Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008;9:11-21.
• Ho PJ, Yen ML, Yet SF, Yen BL. Current applications of human pluripotent stem cells: Possibilities and challenges. Cell Transplant 2012;21:801-14.
• Colter DC, Sekiya I, Prockop DJ. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci U S A 2001;98:7841-5.
• Yamagiwa H, Endo N, Tokunaga K, Hayami T, Hatano H, Takahashi HE. In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2. J Bone Miner Metab 2001;19:20-8.
• Palmer TD, Ray J, Gage FH. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci 1995;6:474-86.
• Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-30.
• Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. Shed: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807-12.
• Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
• Coura GS, Garcez RC, de Aguiar CB, Alvarez-Silva M, Magini RS, Trentin AG. Human periodontal ligament: a niche of neural crest stem cells. J Periodontal Res 2008;43:531-6.
• Morsczeck C, Moehl C, Götz W, Heredia A, Schäffer TE, Eckstein N, et al. In vitro differentiation of human dental follicle cells with dexamethasone and insulin. Cell Biol Int 2005;29:567-75.
• Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I,Webster AR, et al. A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet 2008;45:155-60.
• Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 2008;26:1065-73.
• Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 2005;24:155-65.
• Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, et al. Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype. Exp Biol Med (Maywood) 2010;235:522-30.
• Xu C, Police S, Hassanipour M, Li Y, Chen Y, Priest C, et al. Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells. Regen Med 2011;6:53-66.
• Noguchi H. Production of pancreatic beta-cells from stem cells. Curr Diabetes Rev 2010;6:184-90.
• Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: Accomplishments to date and future promise. Ther Deliv 2010;1:693-705.
• Baddour JA, Sousounis K, Tsonis PA. Organ repair and regeneration: an overview. Birth Defects Res C Embryo Today 2012;96:1-29.
• Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, et al. Myoblast transplantation for heart failure. Lancet 2001;357:279-80.
• Bai H, Wang ZZ. Directing human embryonic stem cells to generate vascular progenitor cells. Gene Ther 2008;15:89-95.
• Hill KL, Obrtlikova P, Alvarez DF, King JA, Keirstead SA, Allred JR, et al. Human embryonic stem cell-derived vascular progenitor cells capable
• of endothelial and smooth muscle cell function. Exp Hematol 2010;38:246-57.
• Levenberg S, Ferreira LS, Chen-Konak L, Kraehenbuehl TP, Langer R. Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells. Nat Protoc 2010;5:1115-26.
• Xu XQ, Graichen R, Soo SY, Balakrishnan T, Rahmat SN, Sieh S, et al. Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation 2008;76:958-70.
• Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, et al. Cd44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 2004;103:2981-9.
• Ben-Hur T. Human embryonic stem cells for neuronal repair. Isr Med Assoc J 2006;8:122-6.
• Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in parkinsonian rats. Stem Cells 2004;22:1246-55.
• Shin S, Mitalipova M, Noggle S, Tibbitts D, Venable A, Rao R, et al. Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions. Stem Cells 2006;24:125-38.
• Hu BY, Du ZW, Zhang SC. Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc 2009;4:1614-22.
• Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, et al. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci USA 2009;106:7613-8.
• Bissonnette CJ, Lyass L, Bhattacharyya BJ, Belmadani A, Miller RJ, Kessler JA. The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells 2011;29:802-11.
• Lee H, Shamy GA, Elkabetz Y, Schofield CM, Harrsion NL, Panagiotakos G, et al. Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 2007;25:1931-9.
• Strauss S. Geron trial resumes, but standards for stem cell trials remain elusive. Nat Biotechnol 2010;28:989-90.
• Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol 2005;23:857-61.
• Sahu S, Tosh D, Hardikar AA. New sources of beta-cells for treating diabetes. J Endocrinol 2009;202:13-6.
• Champeris Tsaniras S, Jones PM. Generating pancreatic beta-cells from embryonic stem cells by manipulating signaling pathways. J Endocrinol 2010;206:13-26.
• Hansen JA, Beatty PG, Anasetti C, Martin PJ, Mickelson E, Thomas ED. Transplantation of hematopoietic stem cells (HSC). Br Med Bull 1987;43:203-16.
• Bhatia M. Hematopoietic development from human embryonic stem cells. Hematology Am Soc Hematol Educ Program 2007:11-6.
• Bhatia M. Hematopoiesis from human embryonic stem cells. Ann N Y Acad Sci 2007;1106:219-22.
• Tucker A, Sharpe P. The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 2004;5:499-508.
• Yamazaki H, Tsuneto M, Yoshino M, Yamamura K, Hayashi S. Potential of dental mesenchymal cells in developing teeth. Stem Cells 2007;25:78-87.
• Giordano G, La Monaca G, Annibali S, Cicconetti A, Ottolenghi L. Stem cells from oral niches: a review. Ann Stomatol (Roma) 2012;2:3-8.
• Ulmer FL, Winkel A, Kohorst P, Stiesch M. Stem cells-prospects in dentistry. Schweiz Monatsschr Zahnmed 2010;120:860-83.
• Peng L, Ye L, Zhou XD. Mesenchymal stem cells and tooth engineering. Int J Oral Sci 2009;1:6-12.
• Rosa V, Della Bona A, Cavalcanti BN, Nör JE. Tissue engineering: from research to dental clinics. Dent Mater 2012;28:341-8.
• Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, et al. The development of a bioengineered organ germ method. Nat Methods 2007;4:227-30.
• Kim BC, Bae H, Kwon IK, Lee EJ, Park JH, Khademhosseini A, et al. Osteoblastic/cementoblastic and neural differentiation of dental stem cells
• and their applications to tissue engineering and regenerative medicine. Tissue Eng Part B Rev 2012;18:235-44.
• Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-4.
• Hu B, Nadiri A, Kuchler-Bopp S, Perrin-Schmitt F, Peters H, Lesot H. Tissue engineering of tooth crown, root, and periodontium. Tissue Eng 2006;12:2069-75.
• Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. J Dent Res 2002;81:531-5.
• Papaccio G, Graziano A, d'Aquino R, Graziano MF, Pirozzi G, Menditti D, et al. Long-term cryopreservation of dental pulp stem cells (SBPDPSCs) and their differentiated osteoblasts: a cell source for tissue repair. J Cell Physiol 2006;208:319-25.
• Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, et al. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biol Int 2007;31:1191-7.
• Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod 2008;34:962-9.
• Nakamura S, Yamada Y, KatagiriW, Sugito T, Ito K, Ueda M. Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp. J Endod 2009;35:1536-42.
• Wang J, Wang X, Sun Z, Wang X, Yang H, Shi S, et al. Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells. Stem Cells Dev 2010;19:1375-83.
• Yokoi T, Saito M, Kiyono T, Iseki S, Kosaka K, Nishida E, et al. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res 2007;327:301-11.
• Kemoun P, Laurencin-Dalicieux S, Rue J, Farges JC, Gennero I, Conte-Auriol F, et al. Human dental follicle cells acquire cementoblast features under stimulation by bmp-2/-7 and enamel matrix derivatives (EMD) in vitro. Cell Tissue Res 2007;329:283-94.
• Yao S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental follicle. J Dent Res 2008;87:767-71.
• Gültekin SE, Odenthall M, Dienes HP. MicroRNA expression in multipotent progenitor cells of dental follicle. Proceedings of the 88th General Session and Exibition of IADR. 2010 July 14-17; Barcelona, Spain.
• Trubiani O, Orsini G, Zini N, Di Iorio D, Piccirilli M, Piattelli A, et al. Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. J Biomed Mater Res A 2008;87:986-93.
• Gay IC, Chen S, MacDougall M. Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod Craniofac Res 2007;10:149-60.
• Lindroos B, Mäenpää K, Ylikomi T, Oja H, Suuronen R, Miettinen S. Characterisation of human dental stem cells and buccal mucosa fibroblasts. Biochem Biophys Res Commun 2008;368:329-35.
• Park JC, Kim JM, Jung IH, Kim JC, Choi SH, Cho KS, et al. Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed pdl tissue: In vitro and in vivo evaluations. J Clin Periodontol 2011;38:721-31.
• Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 2006;1:e79.
• Sonoyama W, Seo BM, Yamaza T, Shi S. Human hertwig's epithelial root sheath cells play crucial roles in cementum formation. J Dent Res 2007;86:594-9.
• Zhu SJ, Choi BH, Huh JY, Jung JH, Kim BY, Lee SH. A comparative qualitative histological analysis of tissue-engineered bone using bone marrow mesenchymal stem cells, alveolar bone cells, and periosteal cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:164-9.
• Cicconetti A, Sacchetti B, Bartoli A, Michienzi S, Corsi A, Funari A, et al. Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:618.e1-12.
• Hunt DP, Irvine KA,Webber DJ, Compston DA, BlakemoreWF, Chandran S. Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord. Cell Transplant 2008;17:865-73.
• Idelson M, Alper R, Obolensky A, Ben-Shushan E, Hemo I, Yachimovich-Cohen N, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell 2009;5:396-408.
• Mohsin S, Shams S, Ali Nasir G, Khan M, Javaid Awan S, Khan SN, et al. Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue. Differentiation 2011;81:42-8.
• Giannoni P, Muraglia A, Giordano C, Narcisi R, Cancedda R, Quarto R, et al. Osteogenic differentiation of human mesenchymal stromal cells on surface-modified titanium alloys for orthopedic and dental implants. Int J Artif Organs 2009;32:811-20.