Kitosan tekstil kompozitli ve elektrostimülasyon ile güçlendirilmiş yara örtüsü tasarımı

Öz

Dekübit ülserleri, yaşam kalitesini olumsuz etkileyen ve uzun tedavi gerektiren yaralardır. Bu çalışmada iyileşmeyi hızlandırmak ve ülser gelişimini azaltmak amacıyla kitosan/gliserol kaplı spacer kumaş ve elektrostimülasyon cihazından oluşan bir yara örtüsü sistemi geliştirilmiştir. Kitosan ve kitosan/gliserol karışımları polyamid (PA) ve polyester (PES) spacer kumaşlara emdirme, baskı ve daldırma yöntemleriyle uygulanmıştır. Kumaşlar; bırakılma/aplikasyon miktarı, elastikiyet, antimikrobiyal aktivite ve elektrostimülasyon performansı açısından değerlendirilmiştir. Kitosan kaplı kumaşlar güçlü antimikrobiyal etki göstermiştir. Gliserol eklenmesiyle şişme ve emilim özellikleri artmış, kumaşlara plastisite kazandırılarak esnek yapı sağlanmıştır. Ayrıca Howland devresi kullanılarak elektrostimülasyon sistemi geliştirilmiş, simülasyonu ve prototipi gerçekleştirilmiştir. Sonuçlar, geliştirilen sistemin dekübit ülseri tedavisinde etkili ve kapsamlı bir yaklaşım sunduğunu, hem hastaların yaşamını iyileştirecek hem de sağlık sektörüne katkı sağlayacak potansiyele sahip olduğunu göstermektedir.

Anahtar Kelimeler

• Dekübit ülserleri
• yara iyileşmesi
• kitosan
• elektrostimülasyon
• spacer kumaş

Chitosan composite textile and electrostimulation enhanced wound dressing design

Öz

Pressure ulcers are wounds that negatively affect quality of life and require long-term treatment. In this study, a wound dressing system composed of chitosan/glycerol-coated spacer fabric, and an electrical stimulation device was developed to accelerate healing and reduce ulcer formation. Chitosan and chitosan/glycerol mixtures were applied to polyamide (PA) and polyester (PES) spacer fabrics using foulard, printing, and dip-coating processes. The fabrics were evaluated in terms of application/retention amount, elasticity, antimicrobial activity, and electrical stimulation performance. Chitosan-coated fabrics showed strong antimicrobial effects. The addition of glycerol improved swelling and absorption properties provided plasticity, and enhanced fabric flexibility. Additionally, an electrical stimulation system was developed using the Howland circuit, with both simulation and prototype completed. The results demonstrated that the designed system offers an effective and comprehensive approach for pressure ulcer treatment, with the potential to improve patients’ quality of life and contribute significantly to the healthcare sector.

Anahtar Kelimeler

• Decubitus ulcers
• wound healing
• chitosan
• electrostimulation
• spacer fabric

Kaynakça

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