Prostat kanserlerinde kapalı döngü aşı uygulaması: benzetim tabanlı bir yaklaşım

Yıl 2026, Cilt: 41 Sayı: 1 , 679 - 692 , 31.03.2026

Reşat Özgür Doruk

https://doi.org/10.17341/gazimmfd.1740422

https://izlik.org/JA57XX26JU

Öz

Bu çalışmanın amacı prostat kanseri immunoterapisinde uygulanabilecek kapalı döngü allojenik tam hücreli aşılama yöntemine ilişkin benzetim tabanlı bir yaklaşım geliştirmektedir. Bu noktada bir denetleyici tasarımı gerekli olup bu araştırmada Lyapunov'un ikinci kararlılık kuramından yararlanılmaktadır. Söz konusu amaca erişebilmek için, prostat kanseri olgusunun gelişimini tanımlayan yenilikçi bir matematiksel modele gereksinim duyulmaktadır. Bu çalışmada kullanılan modelde iki girdi yer almakta olup bunlar sırasıyla allojenik aşılama ve ikincil kemoterapi uygulama hızlarıdır. Yapılan tüm benzetimlerde değişik koşullar incelenmiştir. Bu şartlar alçak ve yüksek başlangış dozları, kontrollü ve serbest aşı uygulanması ve düşük düzeyli kemoterapinin eşlik edip etmemesi durumlarıdır. Yapılan benzetimlerde anlaşılmaktadır ki, eğer sadece düşük başlangıç dozlu bir aşı uygulanıyorsa tümör popülasyonu yavaşça artmaktadır. Kontrol uygulanmadığı durumlarda çok yüksek başlangıç dozu gerekmektedir. Kapalı döngüde ise düşük başlangış dozunda 65 gün içerisinde tam remisyon hali elde edilebilmektedir. Eğer son uygulama düşük dozlu bir kemoterapi ile desteklenirse anılan süre 11 güne kadar düşmektedir.

Anahtar Kelimeler

Prostat kanseri , immünoterapi , dendritik hücre aşılama , Lyapunov kuramı , kapalı döngü tedaviler

Etik Beyan

benzetim tabanlıdır, herhangi bir deney yapılmamıştır.

Destekleyen Kurum

Yoktur. Tamamen kendi insiyatifimle yaptım.

Kaynakça

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