Delphinidin-3-glikozid, hyaluronik asit ve portakal yağı içeren poli-3-hidroksibutirat-ko-3-hidroksiheksaonat membranlarının elektroeğirme yöntemi ile hazırlanması ve antibakteriyel uygulamaları

Yıl 2025, Cilt: 40 Sayı: 2, 837 - 846

Emine Kutlu , Beliz Duyar , Muhammad Asım Ali , Fatih Mehmet Emen , Derya Kılıç , Kumar Sudesh

https://doi.org/10.17341/gazimmfd.1393199

Öz

Bu çalışmada Poli-3-hidroksibutirat-ko-3-hidroksiheksaonat (PHBHHx) ve delphinidin-3-glikozit (antosiyanin, pembe-mor), yüksek nem tutma kapasitesine sahip hyaluronik asit ve portakal yağı içeren ve biyolojik olarak parçalanabilen Poli-3-hidroksibutirat-ko-3-hidroksiheksaonat (PHBHHx-M) mikrofiber örtüleri elektrosipining yöntemi kullanılarak hazırlandı, FT-IR ve XRD teknikleri kullanılarak karakterize edildi. Mikrofiber örtülerinin termal davranışları TG/DTG/DTA kombine sistemiyle, yüzey morfolojileri ise SEM tekniği ile incelendi. Bu Mikrofiber örtülerin antibakteriyel aktivitesi farklı bakteri kültürlerine (Staphylococcus aureus, Escherichia coli, Salmonella enterica, Listeria monocytogenes) karşı incelendi. Antibakteriyel sonuçlarına göre PHBHHx mikrofiber örtülerinin Escherichia coli üzerinde 12,5 mg/mL’de, Staphylococcus aureus ve Salmonella enterica üzerinde 6,25 mg/mL’de, Listeria monocytogenes bakterileri üzerinde ise 3,12 mg/mL’de etkin oldukları görülmektedir. PHBHHx-M mikrofiber örtüleri ise Staphylococcus aureus, Escherichia coli, Salmonella enterica, bakterileri üzerinde 1,56 mg/mL gibi düşük konsantrasyonda etki ederken, Listeria monocytogenes bakterileri üzerinde ise 3,12 mg/mL’de etkinlik göstermiştir. Polimere yapılan antosiyanin, hyaluronik asit ve portakal yağı katkılarının Listeria monocytogenes bakterileri hariç antibakteriyel etkinliği arttırdığı gözlenmiştir. Hazırlanan mikrofiber örtülerin sağlık alanında kullanılma potansiyeli vardır.

Anahtar Kelimeler

Elektroeğirme, Mikrofiber örtüler, Poli(3-hidroksibutirat-ko-3-hidroksiheksanoat, delphinidin-3-glikozit delphinidin-3-glucoside, hyaluronik asit, Portakal yağı.

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