Evaluation of the COVID-19 pandemic process effect on the increase of Precocious Puberty and Premature Thelarche

Yıl 2022, , 32 - 35, 28.02.2022

Nesibe Akyürek

https://doi.org/10.54005/geneltip.1011301

Cited By: 2

Öz

Objective :To determinate COVID-19 pandemic process effect on the increase of Precocious Puberty and Premature Thelarche
Material and Methods: Total 60 girls, younger than 8 years old, who complaint with breast development. Medical history and physical examination findings, bone age, free T4, TSH, FSH, LH, estradiol levels of patients were recorded in their first visits. According to LHRH test results patients were divided to subgroups such as PT and CPP. Differences in the use of technological tools were recorded before and during the pandemic
Results: Higher Body Mass Index (BMI) (P=0.033), bone age (P<0.001) basal LH (P<0.001), basal FSH (P<0.001), basal estradiol (P<0.001) in cases with central puberty precocious level was detected. There was no difference between the two groups in terms of age and weight.
Compared to the pre-pandemic period, there was a significant increase in the use of technological tools (smartphone, computer, television) in both groups. In cases with PT, it was 2.54 ±0.65 hours/day before the pandemic and 6.22±1.25 hours/day during the pandemic (p<0.001), in cases with Spp it was 2.7 ±0.46 hours/day before the pandemic, 7.36±1.36 hours/day during the pandemic (p<0.001). The main reason for using technological tools was school lessons (4.6 ± 1.2 hours/day in cases with Pt, 5±1.2 hours/day in cases with Spp p =0.393).

Conclusion: In our study, it was observed that there was a significant increase in the use of technological devices and puberty symptoms started at a younger age in both groups after the pandemic. It was thought that environmental factors such as weight and increased use of electronic devices triggered the onset of puberty and the rate of progression.

Anahtar Kelimeler

Precocious Puberty, Coronavirus, pandemic

Pubert Prekoks ve Prematur Telarş Sıklığının artmasında COVID-19 pandemi sürecinin etkisinin değerlendirilmesi

Öz

Amaç:
Bu çalışmada amaç; COVID-19 pandemi sürecinin santral puberte prekoks (SPP) ve prematur telarş(PT) sıklığının artış ve ilişkisini araştırmaktır.
Gereç ve Yöntem:
Çocuk Endokrinoloji polikliniğine başvuran 60 kız hasta çalışmaya dahil edildi. Hastaların ilk başvuru anamnez ve fizik muayene bulguları, kemik yaşı, serbest T4, TSH, folikül stimüle edici hormon (FSH), lüteinize edici hormon (LH), estradiol (E2), düzeyleri kaydedildi. Gerekli olgularda yapılmış olan luteinize edici hormon releasing hormon (LH-RH) testi sonucuna göre PT ve SPP olarak ayrıldı. Pandemi öncesi ve sırasında teknolojik araçların kullanımındaki farklılıklar kayıt edildi.
Bulgular:
Santral puberte prekokslu olgularda daha yüksek vücut kitle indeksi (VKİ)(P=0.034), kemik yaşı (p<0.001), bazal LH (P<0.001), bazal FSH(P<0.001), bazal estradiol (P<0.001) düzeyi tespit edildi. Yaş ve kilo bakımından her iki grup arasında farklılık yoktu.
Her iki grupta da pandemi öncesine göre kıyaslandığındateknolojik araçların (akıllı telefon, bilgisayar, televizyon)kullanımında belirgin artış vardı. Prematur telarşı olan olgularda pandemi öncesinde 2,54 ±0,65 saat/gün pandemi sırasında 6,22±1,25 saat/ gün idi (p<0,001). SPP’li olgularda pandemi öncesinde 2,7 ±0,46 saat/gün pandemi sırasında 7,36±1,36 saat/gün idi (p<0,001). Teknolojik araçların kullanımının ana sebebi okul dersleri idi (PT olan olgularda 4,6 ± 1,2 saat/gün, SPP’ li olgularda 5±1,2 saat/gün p=0,393).
Sonuç: Çalışmamızda her iki grubumuzda da pandemi sonrasında teknolojik alet kullanımında belirgin artış olduğu görüldü. Ayrıca santral puberte prekoks başlangıç yaşının erkene kaydığını saptandı. Kilo, elekronik aletlerin kullanımın artışı gibi çevresel faktörlerin ergenlik başlangıcını ve ilerleyiş hızını tetiklediğini düşünüldü.

Anahtar Kelimeler

Puberte Prekoks, Puberte Prekoks, koronavirus, pandemik

Kaynakça

• 1) Partsch CJ, Heger S, Sippell WG. Management and outcome of central precocious puberty. Clin Endocrinol 2002; 56: 129-48.
• 2)Wheeler MD. Physical changes of puberty. Endocrinol Metab Clin North Am 1991;20: 1-14.
• 3) Parent AS, Teilmann G, Juul A,et al. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev. 2003;24(5):668-93.
• 4) Sharma JC. The genetic contribution to pubertal growth and development studied by longitudinal growth data on twins. Ann Hum Biol. 1983;10(2):163-71. 5) Üstün Ç, Özçiftçi S. COVID-19 Pandemisinin sosyal yaşam ve etik düzlem üzerine etkileri: Bir değerlendirme çalışması. Anadolu Kliniği Tıp Bilimleri Dergisi, 2020;25(1), 142-153.
• 6) Caoa, W, Fanga, Z, Houc, G, et al. The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Research, 2020; 287(112934), 1-5.
• 7) Vanderloo LM, Carsley S, Aglipay M,et al. Applying Harm Reduction Principles to Address Screen Time in Young Children Amidst the COVID-19 Pandemic. J Dev Behav Pediatr. 2020 Jun/Jul;41(5):335-336.
• 8) Aktaş B, Daştan NB. Covid-19 pandemisinde üniversite öğrencilerindeki oyun bağımlılığı düzeyleri ve pandeminin dijital oyun oynama durumlarına etkisi. Bağımlılık Dergisi, 2021; 22(2), 129-138.
• 9) Neyzi O, Gunoz H, Furman A, et al. Weight, height, head circumference and body mass index references for Turkish children. Cocuk Sağlığı ve Hastalıkları Dergisi 2008; 51,1-14.
• 10) Neyzi O, Furman A, Bundak R,et al. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95,1635-41.
• 11) Bundak R, Furman A, Gunoz H,et al. Body mass index references for Turkish children. Acta Paediatr 2006; 95.194-198.
• 12) Marshall WA, Tanner JM. Variations in the pattern of pubertalchanges in girls. Arch Dis Child 1969; 44.291-303.
• 13) Atay Z, Turan S, Guran T,et al. The prevalence and risk factors of premature thelarche and pubarche in 4- to8-year-old girls. Acta Paediatr 2012;101: e71-5.
• 14) Bundak R, Darendeliler F, Günöz H, et al. Puberty and Pubertal Growth in Healthy Turkish Girls: No evidence for secular trend. J Clin Res Ped Endo 2008; 1.8–14.
• 15) Neely EK, Crossen SS. Precocious puberty. Curr Opin Obstet Gynecol 2014; 26.332-8.
• 16) Çatlı G, Erdem P, Anık A, et al. Clinical and laboratoryfindings in the differential diagnosis of central precocious pubertyand premature thelarche. Turk Pediatri Ars 2015; 50.20-6.
• 17) Davico C, Ghiggia A, Marcotulli D et al. Psychological Impact of the COVID-19 Pandemic on Adults and Their Children in Italy. Front Psychiatry. 2021 Mar 12; 12:572997
• 18) Liu Q, Zhou Y, Xie X, et al. The prevalence of behavioral problems among school-aged children in home quarantine during the COVID-19 pandemic in china. J Affect Disord. 2021 Jan 15;279:412-416.