Left Sided Breast Cancer Irradiation ; Prone or Supine Simulation ?
Öz
Aim: The aim of this study was to compare radiation doses of target volumes and critical organs among prone and supine positions for left-sided breast cancer patients who were treated with breast-conserving surgery and adjuvant radiotherapy.
Materials and Methods: The doses of critical organs and target volumes were evaluated by using dose-volume histograms on the new radiotherapy plans of twenty patients.
Results: The mean heart dose was lower in the prone position (mean heart doses 656cGy and 933cGy respectively p = 0.01). Mean lung doses for prone and supine positions were 396 cGy and 1032 cGy (p =0.01); lung V5 13% and 33% (p =0.01); lung V10 8% and 25% (p =0.01); lung V20 5% and 17% (p =0.01).
Conclusion: Considering that lower doses of normal structures may reduce side effects, prone position may be preferred in patients with left breast cancer.
Anahtar Kelimeler
breast cancer, radiotherapy, prone position, supine position
Kaynakça
- 1.DeSantis CE, Ma J, Gaudet MM, et al. Breast cancer statistics, 2019. CA Cancer J Clin 2019;69(6):438-451.
- 2.Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(16):1233-1241.
- 3.Early Breast Cancer Trialists' Collaborative G. Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. N Engl J Med 1995;333(22):1444-1455.
- 4.Van Dongen JA, Voogd AC, Fentiman IS, et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92(14):1143-1150.
- 5.Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347(16):1227-1232.
- 6.Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol 2005;6(8):557-565.
- 7.Henson KE, McGale P, Taylor C, Darby SC. Radiation-related mortality from heart disease and lung cancer more than 20 years after radiotherapy for breast cancer. Br J Cancer 2013;108(1):179-182.
- 8.Nielsen MH, Berg M, Pedersen AN, et al. Delineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: national guidelines and contouring atlas by the Danish Breast Cancer Cooperative Group. Acta Oncol 2013;52(4):703-710.
- 9.Moiseenko V, Einck J, Murphy J, et al. Clinical evaluation of QUANTEC guidelines to predict the risk of cardiac mortality in breast cancer patients. Acta Oncol 2016;55(12):1506-1510.
- 10.Marks LB, Bentzen SM, Deasy JO, et al. Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 2010;76(3 Suppl):S70-76.