Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1

Ümmügülsüm Can

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Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1

Öz

Oksidatif stres fazla oksidant bileşiğin yapılması ve antioksidant koruma mekanizmasının azlığı sonucu oluşarak doku hasarlarına yol açar. Oksidatif stres sonucu oluşan okside-düşük dansiteli lipoprotein oxidized low-density lipoprotein ox-LDL , reseptörü lektin benzeri ox-LDL reseptör-1 lectin-like receptor for ox-LDL-1 LOX-1 ’e bağlanır. ox-LDL ve LOX-1 endotel disfonksiyonu, monosit adezyonu, düz kas hücre proliferasyon, migrasyon ve apoptozis, yağ hücre yapımı ve trombosit aktivasyonu ile ilgili mekanizmalarda görev alır. ox-LDL, ateroskleroz, diabetes mellitus, yaşlanma, metabolik sendrom, kardiovasküler, ve serebrovasküler, böbrek ve karaciğer hastalıklarında artarak hastalıkların patogenezlerinde aktif rol alır. Bu derlemede, ox-LDL ve reseptörü LOX-1 etkileri incelenmiştir

Anahtar Kelimeler

Okside-LDL, lektin benzeri okside-LDL reseptör-1, kardiyovasküler hastalıklar

Kaynakça

Itabe H, Ueda M. Measurement of plasma oxidized low-density lipoprotein and its clinical implications. J Atheroscler Thromb 2007;14:1-11.
Kim HJ, Yuan J, Norris K, Vaziri ND.High-calorie diet par- tially ameliorates dysregulation of intrarenal lipid metabo- lism in remnant kidney. J Nutr Biochem 2010; 21:999-1007.
Schreurs MP, Cipolla MJ. Cerebrovascular dysfunction and blood-brain barrier permeability induced by oxidized LDL are prevented by apocynin and magnesium sulfate in fema- le rats. J Cardiovasc Pharmacol 2014; 63:33-9.
Oteiza A, Li R, McCuskey RS, Smedsrİd B, Sİrensen KK. Effects of oxidized low-density lipoproteins on the hepatic microvasculature. Am J Physiol Gastrointest Liver Physiol 2011;301:G684-93.
Maiolino G, Rossitto G, Caielli P et al. The role of oxidized low-density lipoproteins in atherosclerosis: the myths and the facts. Mediators Inflamm 2013;2013:714653.
Pirillo A, Norata GD, Catapano AL. LOX-1, OxLDL, and atherosclerosis. Mediators Inflamm 2013;2013:152786.
Homma Y. Predictors of atherosclerosis. J Atheroscler Thromb 2004;11:265-70.
Sakurai K, Sawamura T. Stress and vascular responses: en- dothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: close relationships with oxidative stress. J Pharmacol Sci 2003;91:182-6.
Mertens A, Holvoet P. Oxidized LDL and HDL: antagonists in atherothrombosis. FASEB J 2001;15:2073-84.
Yoshimoto R, Fujita Y, Kakino A et al. The discovery of LOX-1, its ligands and clinical significance. Cardiovasc Drugs Ther 201;25:379-91.

Xu S, Ogura S, Chen J et al. LOX-1 in atherosclerosis: bio- logical functions and pharmacological modifiers. Cell Mol Life Sci 2013;70:2859-72.
Navarra T, Del Turco S, Berti S, Basta G. The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications. J Atheroscler Thromb 2010;17:317-31.
Walenbergh SM, Koek GH, Bieghs V, Shiri-Sverdlov R. Non-alcoholic steatohepatitis: the role of oxidized low-den- sity lipoproteins. J Hepatol 2013;58:801-10.
Li R, Oteiza A, Sİrensen KK et al. Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins. Am J Physiol Gastrointest Liver Physiol 2011;300:G71-81.
Musso G, Cassader M, De Michieli F et al. Effect of lec- tin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis. Am J Clin Nutr 2011;94:1033-42.
Lee HS, Kim YS. Identification of oxidized low density li- poprotein in human renal biopsies. Kidney Int 1998;54:848- 56.
Itabe H, Yamamoto H, Imanaka T et al. Sensitive detection of oxidatively modified low density lipoprotein using a mo- noclonal antibody. J Lipid Res 1996; 37:45-53.
Ehara S, Ueda M, Naruko T et al. Elevated levels of oxi- dized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation 2001;103:1955-60.
Itabe H, Suzuki K, Tsukamoto Yet al. Lysosomal accumu- lation of oxidized phosphatidylcholine-apolipoprotein B complex in macrophages: intracellular fate of oxidized low density lipoprotein. Biochim Biophys Acta 2000;1487:233- 45.
Gradinaru D, Borsa C, Ionescu C, Margina D. Advanced oxidative andglycoxidative protein damage markers in the elderly with type 2 diabetes. J. Proteomics 2013;92:313-22.
Lapointe A, Couillard C, Piche ME et al. Circulating oxi- dized LDL is associated with parameters of the metabolic syndrome in postmenopausal women. Atherosclerosis 2007 191:362-8.
Profumo E, Di Franco M, Buttari B et al. Biomarkers of- subclinical atherosclerosis in patients with autoimmune disorders. MediatorsInflamm 2012;2012:503942.
Besler HT, Comoglu S. Lipoprotein oxidation, plasma to- tal antioxidantcapacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci 2003;6:189-96.
Dildar K, Sinem F, Gökhan E, Orhan Y, Filiz M. Serum nitrosative stresslevels are increased in Alzheimer disease but not in vascular dementia. Alzheimer Dis. Assoc. Disord 2010;24:194-7.
Robman L, McNeil J, Dimitrov P et al. Methodology of the cardiovascularhealth and age-related maculopathy (CHARM) study. Ophthalmic Epidemiol 2004;11:161-79.
Mazière C, Savitsky V, Galmiche A et al. Oxidized low den- sity lipoprotein inhibits phosphate signaling andphospha- te-induced mineralization in osteoblasts. Involvement of oxidativestress. Biochim Biophys Acta 2010;1802:1013-19.
Kankaanpää J, Turunen SP, Moilanen V, Hörkkö S, Re- mes AM. Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer’sdisease. Neurobiol Dis 2009;33:467-72.
Hayashida K, Kume N, Murase T et al. Serum soluble lec- tin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome a novel marker for early diagnosis. Circular 2005;112:812-8.
Kobayashi N, Takano M, Hata N et al. Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic- marker for rupture of thin-cap fibroatheroma: verification by opticalcoherence tomography. Int J Cardiol 2013;168: 3217-23.
Chen M, Kakutani M, Minami M. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 2000;20:1107-15.
Nagase M, Hirose S, Sawamura T, Masaki T, Fujita T. En- hanced expression of endothelial oxidized low-density li- poprotein receptor (LOX-1) in hypertensive rats. Biochem Biophys Res Commun 1997;237:496-8.
Kume N, Sawamura T, Moriwaki H et al. Inducible expres- sion of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in vascular endothelial cells. Circ Res 1998;83:322-7.
Murase T, Kume N, Korenaga R et al. Fluid shear stress transcriptionally induces lectin-like oxidized LDL recep- tor-1 in vascular endothelial cells. Circ Res 1998;83:328-33.
Kataoka H, Miyamoto S. Expression of lectin-like oxidized lowdensity lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 1999;99:3110-7.
Chen M, Nagase M, Fujita T et al. Diabetes enhances lec- tin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and age. Biochem Biophys Res Commun 2001;87:962-8.
Honjo M, Nakamura K, Yamashiro K et al. Lectin-like oxi- dized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci U S A 2003;100:1274-9.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Ümmügülsüm Can Bu kişi benim

Yayımlanma Tarihi

1 Aralık 2016

Gönderilme Tarihi

-

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 26 Sayı: 4

IZ

https://izlik.org/JA67DC94UK

APA

Can, Ü. (2016). Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1. Genel Tıp Dergisi, 26(4), 121-126. https://izlik.org/JA67DC94UK

AMA

1.Can Ü. Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1. Genel Tıp Derg. 2016;26(4):121-126. https://izlik.org/JA67DC94UK

Chicago

Can, Ümmügülsüm. 2016. “Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1”. Genel Tıp Dergisi 26 (4): 121-26. https://izlik.org/JA67DC94UK.

EndNote

Can Ü (01 Aralık 2016) Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1. Genel Tıp Dergisi 26 4 121–126.

IEEE

[1]Ü. Can, “Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1”, Genel Tıp Derg, c. 26, sy 4, ss. 121–126, Ara. 2016, [çevrimiçi]. Erişim adresi: https://izlik.org/JA67DC94UK

ISNAD

Can, Ümmügülsüm. “Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1”. Genel Tıp Dergisi 26/4 (01 Aralık 2016): 121-126. https://izlik.org/JA67DC94UK.

JAMA

1.Can Ü. Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1. Genel Tıp Derg. 2016;26:121–126.

MLA

Can, Ümmügülsüm. “Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1”. Genel Tıp Dergisi, c. 26, sy 4, Aralık 2016, ss. 121-6, https://izlik.org/JA67DC94UK.

Vancouver

1.Ümmügülsüm Can. Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1. Genel Tıp Derg [Internet]. 01 Aralık 2016;26(4):121-6. Erişim adresi: https://izlik.org/JA67DC94UK

Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.

Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1

Öz

Anahtar Kelimeler

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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