Investigation of the Effect of Acamprosate Treatment on Heart Contractions in Alcohol-Dependent Rats
Öz
Background/ Aim: Chronic alcohol use leads to impaired heart contraction and also causes a direct toxic effect on myocardial function. Acamprosate, which is widely used in alcohol dependence, is not known to have a pharmacological effect on cardiac contraction. Therefore, this study aimed to investigate the effects of acamprosate on the heart muscle.
Materials and Methods: A total of 32 female Wistar rats were divided four groups as control (10 mg/kg/g saline) group, alcohol (10 mg/kg/g alcohol + 10 mg/kg/g saline) group, acamprosate (200 mg/kg/g) group and alcohol+ acamprosate groups (10 mg/kg/g alcohol + 200 mg/kg/g acamprosate + 10 mg/kg/g saline). Alcoholic rats were scored for alcohol dependence and withdrawal. After that, the rats were sacrificed, respectively and the heart tissue was removed. The amplitude and contraction frequencies of the atrium tissue taken from the heart tissue were measured in the isolated tissue bath.
Results: Alcohol dependence and withdrawal symptoms were observed in the Alcohol group and Alcohol+Acamprosate group (p<0ç05). When atrium contractions were investigated in all groups, a statistically significant difference was found between the tension values (p<0.05).
Conclusion: The use of acamprosate has been found to have negative effects on heart contraction. It would be useful to consider this effect in terms of the treatment protocol.
Anahtar Kelimeler
Alcohol, Alcohol dependence, acamprosate, heart contraction, isolated tissue bath
Destekleyen Kurum
NECMETTİN ERBAKAN ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ KOORDİNATÖRLÜĞÜ
Proje Numarası
211354001
Teşekkür
The present research was supported by Necmettin Erbakan University Scientific Research Projects (BAP) within the scope of project number 211354001. Thanks to Necmettin Erbakan University Scientific Research Projects (BAP) Coordinator for its financial support.
Kaynakça
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