The Relationship Between Vitamin D Levels and Severity of Menopausal Symptoms
Öz
Introduction: Our aim was to investigate the relationship between menopausal symptoms and serum vitamin D levels.
Methods: We analyzed 110 postmenopausal women aged between 42-65 years among menopause symptoms by using Menopause Rating Scale (MRS) questionnaire. Patients were divided into three groups according to their serum 25-OH vitamin D levels; sufficient (>20 ng/mL), insufficient (12-20 ng/mL), deficient (<12 ng/mL), then compared. Serum vitamin D cut-off level was determined for menopausal symptoms. The correlations between symptoms and vitamin D status were calculated.
Results: Vitamin D deficiency was detected in 38,1% (42/110) of the participants. The total MRS score was 22,97±2,71 in Vitamin D deficiency group and significantly higher than others (p<0,001). In deficiency group, somatic, psyhcological and urogenital subscale scores were higher than other groups (p<0,001, p=0,007 and p=0,036, respectively). Evaluation of the correlations among independent variables revealed a negative relationship between vitamin D level and MRS scores. The threshold value at which serum vitamin D causes severe MRS scores in those with sufficient levels was calculated as 25.31 ng/ml. The area under the ROC curve was 0,876 (95% CI, 0,702-1,00, p=0.003).
Conclusion: In the present study, a relationship between serum vitamin D levels and menopause-related symptoms in postmenopausal population was demonstrated. Low levels of vitamin D in menopausal period might aggravate menopause-related symptoms.
Anahtar Kelimeler
Kaynakça
- 1. Roberts H, Hickey M. Managing the menopause: An update. Maturitas 2016, 86: 53-58.
- 2. Proceedings from the NIH State-of-the-Science Conference on Management of Menopause-Related Symptoms, March 21-23, 2005, Bethesda, Maryland, USA. In: The American journal of medicine 2005. 142.12_Part_1: 1003-1013
- 3. Conde DM, Pinto-Neto AM, Santos-Sá D, Costa-Paiva L, Martinez EZ. Factors associated with quality of life in a cohort of postmenopausal women. Gynecol Endocrinol 2006; 22.8: 441-446.
- 4. Bouillon R, Carmeliet G, Verlinden L,et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008 Oct;29(6):726-76.
- 5. Cass WA, Smith MP, Peters LE. Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. In: Annals of the New York Academy of Sciences 2006, 1074.1: 261-271.
- 6. Rossmanith WG, Ruebberdt W. What causes hot flushes? The neuroendocrine origin of vasomotor symptoms in the menopause. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol 2009 May;25(5):303–14.
- 7. Foti D, Greco M, Cantiello F, et al. Hypovitaminosis D and Low Urinary Tract Symptoms in a Female Population. Eur J Inflamm [Internet] 2014 May 1;12(2):365–72.
- 8. Arvold DS, Odean MJ, Dornfeld MP, et al. Corelation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: A randomized controlled trial. Endocr Pract 2009; 15(3), 203-212.
- 9. Metintas S, Arikan I, Kalyoncu C, Ozalp S. Menopause Rating Scale as a screening tool in rural Turkey. Rural Remote Health 2010 10(1), 27-37.
- 10. Potthoff P, Heinemann LAJ, Schneider HPG, Rosemeier HP, Hauser GA. Menopause-Rating-Skala (MRS II): Methodische standardisierung in der deutschen bevolkerung. Zentralbl Gynakol 2000; 122: 280-6.