The Evaluation of Cardiovascular System Before and After Renal Transplantation and Its Relationship Between Brain Natriuretic Peptide
Öz
Aim: To evaluate the cardiovascular system functions biochemically and echocardiographically in renal transplant recipients before and after transplantation.
Materials and Methods: Patients who were followed up in Gazi University Faculty of Medicine, Department of Pediatric Nephrology and diagnosed with CRF, and underwent renal transplantation before the age of 18 were included in the study. A control group was formed from healthy volunteers. BMI, biochemical values, echocardiographic findings, and CIMT measurements of these patients before and after transplantation were compared. Tissue Doppler imaging and BNP values performed after transplantation were compared with the control group.
Results: Data from 64 subjects (patient group;32, healthy control group;32) were evaluated. Values of the patients before and after renal transplantation were compared. BMI values increased significantly after transplantation compared to pre-transplantation (p<0.001), CIMT values decreased statistically significantly after transplantation (p<0.001), LVM and LVMI values decreased significantly after transplantation (p<0.001), and mitral E/A ratio was found to regress after transplantation (1.68±0.65 vs. 1.45±0.29)(p<0.001). When the values of the patients in the post-transplant period were compared with the healthy controls; it was found that LVMI, MPI, CIMT, and BNP values were significantly higher than healthy controls (p<0.05). It was found that BNP was significantly negatively correlated with BMI, but was not correlated with MPI.
Conclusion: Cardiac risk factors of post-renal transplant patients are significantly reduced after transplantation, but it is still higher than the healthy controls. Measurement of MPI and LVMI is important in predicting cardiovascular risk status after renal transplantation.
Anahtar Kelimeler
Chronic renal failure, renal transplatation, natriuretic peptide, left ventricular mass index, myocardial performance index
Destekleyen Kurum
none
Proje Numarası
none
Teşekkür
none
Kaynakça
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