Araştırma Makalesi

Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?

Cilt: 33 Sayı: 4 31 Ağustos 2023
Hakan Ozer *, Kader Zeybek Aydoğan , Yasin Öztürk , Fethi Yönet , İsmail Baloğlu
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Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?

Öz

Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR. Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count. Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria. Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.

Anahtar Kelimeler

Albuminuria, diabetic nephropathy, inflammation, monocyte-hdl cholesterol ratio, Albüminüri, diyabetik nefropati, inflamasyon, monosit-HDL kolesterol oranı

Kaynakça

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  6. Van Dijk C, Beri T. Pathogenesis of diabetic nephropathy. Rev Endocr Metab Disord 2004;5:237-48.
  7. Barter PJ, Nicholls S, Rye KA, et al. Antiinflammatory properties of HDL. Circ Res. 2004;95:764–772.
  8. Assmann G, Gotto AM. HDL cholesterol and protective factors in atherosclerosis. Circulation. 2004; 109(23)1: 308-14.
  9. Kanbay M, Solak Y, Unal HU, Kurt YG, Gok M, Cetinkaya H et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 2014; 46(8): 1619-25.
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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Erken Görünüm Tarihi

29 Ağustos 2023

Yayımlanma Tarihi

31 Ağustos 2023

Gönderilme Tarihi

23 Kasım 2022

Kabul Tarihi

3 Haziran 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 33 Sayı: 4

DOI

https://doi.org/10.54005/geneltip.1206894

IZ

https://izlik.org/JA33EH27UB

Kaynak Göster

RIS / Bibtex
APA
Ozer, H., Zeybek Aydoğan, K., Öztürk, Y., Yönet, F., & Baloğlu, İ. (2023). Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Dergisi, 33(4), 384-389. https://doi.org/10.54005/geneltip.1206894
AMA
1.Ozer H, Zeybek Aydoğan K, Öztürk Y, Yönet F, Baloğlu İ. Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Derg. 2023;33(4):384-389. doi:10.54005/geneltip.1206894
Chicago
Ozer, Hakan, Kader Zeybek Aydoğan, Yasin Öztürk, Fethi Yönet, ve İsmail Baloğlu. 2023. “Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?”. Genel Tıp Dergisi 33 (4): 384-89. https://doi.org/10.54005/geneltip.1206894.
EndNote
Ozer H, Zeybek Aydoğan K, Öztürk Y, Yönet F, Baloğlu İ (01 Ağustos 2023) Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Dergisi 33 4 384–389.
IEEE
[1]H. Ozer, K. Zeybek Aydoğan, Y. Öztürk, F. Yönet, ve İ. Baloğlu, “Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?”, Genel Tıp Derg, c. 33, sy 4, ss. 384–389, Ağu. 2023, doi: 10.54005/geneltip.1206894.
ISNAD
Ozer, Hakan - Zeybek Aydoğan, Kader - Öztürk, Yasin - Yönet, Fethi - Baloğlu, İsmail. “Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?”. Genel Tıp Dergisi 33/4 (01 Ağustos 2023): 384-389. https://doi.org/10.54005/geneltip.1206894.
JAMA
1.Ozer H, Zeybek Aydoğan K, Öztürk Y, Yönet F, Baloğlu İ. Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Derg. 2023;33:384–389.
MLA
Ozer, Hakan, vd. “Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?”. Genel Tıp Dergisi, c. 33, sy 4, Ağustos 2023, ss. 384-9, doi:10.54005/geneltip.1206894.
Vancouver
1.Hakan Ozer, Kader Zeybek Aydoğan, Yasin Öztürk, Fethi Yönet, İsmail Baloğlu. Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Derg. 01 Ağustos 2023;33(4):384-9. doi:10.54005/geneltip.1206894

Cited By

Association of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio and monocyte‐to‐high‐density lipoprotein ratio with diabetic nephropathy

Therapeutic Apheresis and Dialysis

https://doi.org/10.1111/1744-9987.70008

Association Between Monocyte‐to‐High‐Density Lipoprotein Ratio and Diabetic Nephropathy: A Systematic Review and Meta‐Analysis

BioMed Research International

https://doi.org/10.1155/bmri/1097476


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