COVID-19 Enfekte Hastalarda Tromboembolik Olayların Araştırılması

Yıl 2023, , 56 - 60, 28.02.2023

Serpil Şahin , Hatice Betül Altınışık , Sevil Alkan Çeviker , Uğur Küçük , Havva Yasemin Çinpolat , Uğur Gönlügür

https://doi.org/10.54005/geneltip.1209433

Öz

Amaç: Bu çalışmada, hastaneye yatırılan COVID-19 hastalarında tromboembolik olayların (TEE) sıklığının yanı sıra bu komplikasyonu yaşayan hastaların klinik sonuçları ve hasta özelliklerini belirlemeye çalıştık.
Gereç ve Yöntemler: Ocak 2020 ile Aralık 2021 tarihleri ​​arasında COVID-19 PCR testi pozitif olan tüm hastalar bu çalışmaya dahil edildi. COVID-19 tanısı ile TEE gelişen olguların verileri retrospektif olarak değerlendirildi.
Bulgular: Bu süre zarfında 2.845 yatan hasta COVID-19 ile başvurdu. Bu gruptan 96 hastada (%3,37) COVID-19 ile ilişkili TEE vardı. Ortalama yaş 63,76±13,85 (aralık, 28-80), 46 erkek (%47,92) ve 50 kadın (%52,08) idi. Hastaların 96'sından 46'sında (%47,92) şiddetli COVID-19, 50'sinde (%52,08) sadece hafif solunum semptomları vardı. Şiddetli COVID-19 grubu hastalar daha yaşlıydı ancak gruplar arasında istatistiksel olarak anlamlılık yoktu. Hafif COVID-19 grubunda periferik venöz hastalık daha sık görülürken, şiddetli COVID-19 grubunda periferik arter hastalığı daha yaygındı. Ağır COVID-19 hastalarında CRP, ürik asit, troponin, kreatinin, D-dimer ve lökosit seviyeleri daha yüksekti TEE ile (p<0.05). 96 olgunun 81'inde (%84,37) periferik venöz hastalık, 5'inde (%5,2) periferik arter hastalığı ve 11'inde (%11,45) pulmoner emboli vardı. Bir hastada (%1.04) hem periferik venöz hastalık hem de pulmoner emboli vardı. Genel mortalite %6.25 (6/96) idi.
Sonuç: COVID-19 ile ilişkili trombotik süreç, arterlerden daha sık damarları etkiler. COVID-19'da TEE için önemli gözlemlenen risk göz önüne alındığında, TEE için tanısal görüntüleme yüksek derecede klinik şüphe ile değerlendirilmelidir.

Anahtar Kelimeler

COVID-19, SARS-CoV-2, Thrombosis, Embolism

Investigation of Thromboembolic Events in COVID-19 Infected Patients

Öz

Aim: In this study, we sought to determine patient characteristics and clinical outcomes of patients who experience this complication, as well as the frequency of thromboembolic events (TEE) in COVID-19 patients hospitalized.
Materials and Methods: Between January 2020 and December 2021, all the patients with positive COVID-19 PCR test results were enrolled in this study. The data of the cases that developed TEE with the diagnosis of COVID-19 were evaluated retrospectively.
Results:During this time, 2,845 inpatients were admitted with COVID-19. Among this group, 96 patients (3.37%) had COVID-19 - related TEE. The mean age was 63.76±13.85 years (range, 28–80 years) with 46 men (47.92%) and 50 women (52.08%). Of the patients, 46 of 96 (47.92%) had severe COVID-19, and 50 of 96 (52.08%) had only mild respiratory symptoms. Severe COVID-19 group patients were older but there was not statistically significance between the groups. Peripheral venous disease was more common in mild COVID-19 group, while peripheral arterial disease is more common in severe COVID-19 group.CRP, uric acid, troponin, creatinine,D-dimer and leukocyte levels were higher in severe COVID-19 patients with TEE (p<0.05). Peripheral venous disease was present in 81 of 96 (84.37%), peripheral arterial disease in 5 of 96 (5.2%), and pulmonary embolism in 11 (11.45%) cases. One patient (1.04%) had both peripheral venous disease and pulmonary embolism. The overall mortality was 6.25% (6/96).
Conclusion: COVID-19-associated thrombotic process affects more frequently veins than arteries. Given the significant observed risk for TEE in COVID-19, diagnostic imaging for TEE should be evaluated with a high degree of clinical suspicion.

Anahtar Kelimeler

COVID-19, SARS-CoV-2, Thrombosis, Embolism

Kaynakça

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