The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease

Serhat Çalışkan; Ferit Böyük

doi:10.54005/geneltip.1217304

EN TR

The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease

Öz

Background/Aim: In our study, we aimed to evaluate the effect of mean platelet volume/platelet count ratio on the development of peripheral artery disease (PAD) by comparing it with the control group. Material and Methods: A total of 115 patients with peripheral artery disease as a result of lower extremity color Doppler ultrasonography examination in our hospital were included in the study as the patient group and 100 individuals without peripheral artery disease as the control group. Results: History of coronary artery disease (p<0.001), diabetes mellitus (p=0.009), hypertension (p<0.001) and smoking history (p<0.001) were significantly higher in the PAD group than in the control group. Serum glucose (121.27±25.66 vs. 104.81±34.77; p<0.001), MPV levels (9.99±0.79 vs. 9.04±0.7; p<0.001) and MPV/PLT ratio (0.041±0.07 vs. 0.037±0.006, p< 0.001) were found to be significantly higher in the PAD group than in the control group. Serum HDL levels (45.03±11.5 vs. 48.67±12.52 p=0.026) were significantly lower in the PAD group than in the control group. In multivariate analysis, age, MPV and MPV/PLT ratio were determined as independent predictors for peripheral arterial disease. Conclusion: In our study, we found that MPV and MPV/PLT ratio were independent predictors of peripheral artery disease.

Anahtar Kelimeler

Peripheral arterial disease, Platelet activation, Mean Platelet Volume, Mean Platelet Volume/Platelet Count Ratio, Periferik arter hastalığı, Trombosit aktivasyonu, Ortalama Trombosit Hacmi, Ortalama Trombosit Hacmi/Platelet Sayısı Oranı

Proje Numarası

Yok

Ortalama Trombosit Hacmi/Trombosit Sayısı (MPV/PLT Oranı ile Periferik Arter Hastalığı Arasındaki İlişki

Öz

Amaç: Çalışmamızda ortalama trombosit hacmi/trombosit sayısı oranının periferik arter hastalığı (PAH) gelişimine etkisini kontrol grubu ile karşılaştırarak değerlendirmeyi amaçladık. Yöntem: Hastanemizde alt ekstremite renkli Doppler ultrasonografi incelemesi sonucu periferik arter hastalığı saptanan toplam 115 hasta ile periferik arter hastalığı olmayan 100 kişi kontrol olarak çalışmaya alınmıştır. Bulgular: Periferik arter hastalığı (PAD) olan grupta ortalama yaş kontrol grubuna göre anlamlı olarak yüksek bulunmuştur (69.12±10.58 vs. 52.83±13.05, p<0.001). Grupların cinsiyet oranlarında istatistiksel olarak anlamlı fark yoktur (p=0.218). Koroner arter hastalığı öyküsü (p<0.001), diabetes mellitus (p=0.009), hipertansiyon (p<0.001) ve sigara öyküsü (p<0.001) PAH grubunda kontrol grubuna göre anlamlı olarak yüksek bulunmuştur. Serum glukozu (121,27±25,66 - 104,81±34,77; p<0,001), MPV seviyeleri (9,99±0,79 - 9,04±0,7; p<0,001) ve MPV/PLT oranı (0,041±0,07 - 0,037±0,006, p< 0.001) PAD grubunda kontrol grubuna göre anlamlı olarak yüksek bulunmuştur. Serum HDL düzeyleri (45,03±11,5'e karşı 48,67±12,52 p=0,026) PAD grubunda kontrol grubuna göre anlamlı olarak düşüktür. Çok değişkenli analizde yaş, MPV ve MPV/PLT oranı periferik arter hastalığı için bağımsız belirteçler olarak belirlenmiştir. Sonuç: Çalışmamızda MPV ve MPV/PLT yapıları periferik arter yapısından bağımsız aygıtları bulunmuştur.

Anahtar Kelimeler

Periferik arter hastalığı, Trombosit aktivasyonu, Ortalama Trombosit Hacmi, Ortalama Trombosit Hacmi/Platelet Sayısı Oranı

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Serhat Çalışkan
0000-0002-0260-5463
Türkiye

Ferit Böyük ^*
0000-0003-2313-1495
Türkiye

Yayımlanma Tarihi

28 Şubat 2023

Gönderilme Tarihi

10 Aralık 2022

Kabul Tarihi

22 Ocak 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 33 Sayı: 1

DOI

https://doi.org/10.54005/geneltip.1217304

IZ

https://izlik.org/JA27LE49PY

APA

Çalışkan, S., & Böyük, F. (2023). The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease. Genel Tıp Dergisi, 33(1), 76-81. https://doi.org/10.54005/geneltip.1217304

AMA

1.Çalışkan S, Böyük F. The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease. Genel Tıp Derg. 2023;33(1):76-81. doi:10.54005/geneltip.1217304

Chicago

Çalışkan, Serhat, ve Ferit Böyük. 2023. “The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease”. Genel Tıp Dergisi 33 (1): 76-81. https://doi.org/10.54005/geneltip.1217304.

EndNote

Çalışkan S, Böyük F (01 Şubat 2023) The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease. Genel Tıp Dergisi 33 1 76–81.

IEEE

[1]S. Çalışkan ve F. Böyük, “The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease”, Genel Tıp Derg, c. 33, sy 1, ss. 76–81, Şub. 2023, doi: 10.54005/geneltip.1217304.

ISNAD

Çalışkan, Serhat - Böyük, Ferit. “The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease”. Genel Tıp Dergisi 33/1 (01 Şubat 2023): 76-81. https://doi.org/10.54005/geneltip.1217304.

JAMA

1.Çalışkan S, Böyük F. The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease. Genel Tıp Derg. 2023;33:76–81.

MLA

Çalışkan, Serhat, ve Ferit Böyük. “The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease”. Genel Tıp Dergisi, c. 33, sy 1, Şubat 2023, ss. 76-81, doi:10.54005/geneltip.1217304.

Vancouver

1.Serhat Çalışkan, Ferit Böyük. The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease. Genel Tıp Derg. 01 Şubat 2023;33(1):76-81. doi:10.54005/geneltip.1217304

Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.

The Relationship Between Mean Platelet Volume/Platelet Count (MPV/ PLT) Ratio and Peripheral Artery Disease

Öz

Anahtar Kelimeler

Proje Numarası

Ortalama Trombosit Hacmi/Trombosit Sayısı (MPV/PLT Oranı ile Periferik Arter Hastalığı Arasındaki İlişki

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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