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Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?

Cilt: 33 Sayı: 3 30 Haziran 2023
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Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?

Öz

Objective:The purpose of this study is to investigate the utility of systemic immune inflammation index as a predictor of disease severity in patients with knee osteoarthritis. Methods: 200 patients diagnosed with knee osteoarthritis according to ACR knee osteoarthritis diagnostic criteria were included in the study. Kellgren-Lawrence staging of knee osteoarthritis, Western Ontario and McMaster University Osteoarthritis (WOMAC) index score and systemic immune-inflammation index score were calculated among all participants Results: There were 152 (%76) female and 48 (%24) male participants and median score of age was 63 (54,25-70). 14 (7%) grade 1 gonarthrosis, 64 (32%) grade 2, 72 (36%) grade 3 and 50 (25%) grade 4 gonarthrosis patients were detected. There was no significant correlation between the systemic immune-inflammation index and the radiological stage of gonarthrosis (Kellgren Lawrens Score) (p=0.238). No statistically significant correlation was found between the systemic immune-inflammation index and WOMAC scores (p=0.593). Conclusion: The systemic immune-inflammation index was not found to be correlated with disease severity in knee OA.

Anahtar Kelimeler

Knee osteoarthritis, inflammation mediators, disease severity, systemic immune-inflammation index

Destekleyen Kurum

none

Kaynakça

  1. Bannuru, R.R., et al., Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med, 2015. 162(1): p. 46-54.
  2. Sacitharan, P.K., Ageing and Osteoarthritis. Subcell Biochem, 2019. 91: p. 123-159.
  3. Kulkarni, P., et al., Pathophysiological landscape of osteoarthritis. Adv Clin Chem, 2021. 100: p. 37-90.
  4. Geyer, M. and C. Schönfeld, Novel Insights into the Pathogenesis of Osteoarthritis. Curr Rheumatol Rev, 2018. 14(2): p. 98-107.
  5. Fusco, M., et al., Degenerative Joint Diseases and Neuroinflammation. Pain Pract, 2017. 17(4): p. 522-532.
  6. Geraghty, T., et al., Neuroimmune interactions and osteoarthritis pain: focus on macrophages. Pain reports, 2021. 6(1).
  7. Ishijima, M., H. Kaneko, and K. Kaneko, The evolving role of biomarkers for osteoarthritis. Ther Adv Musculoskelet Dis, 2014. 6(4): p. 144-53.
  8. Imamura, M., et al., Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization. Int J Inflam, 2015. 2015: p. 329792.
  9. Taşoğlu, Ö., et al., Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity? Clin Rheumatol, 2016. 35(6): p. 1579-83.
  10. Satis, S., New Inflammatory Marker Associated with Disease Activity in Rheumatoid Arthritis: The Systemic Immune-Inflammation Index. Curr Health Sci J, 2021. 47(4): p. 553-557.

Kaynak Göster

APA
Karpuz, S., Yılmaz, R., Özkan, M., Tunçez, İ. H., Kalaoğlu, E., & Yılmaz, H. (2023). Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis? Genel Tıp Dergisi, 33(3), 305-308. https://doi.org/10.54005/geneltip.1228775
AMA
1.Karpuz S, Yılmaz R, Özkan M, Tunçez İH, Kalaoğlu E, Yılmaz H. Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis? Genel Tıp Derg. 2023;33(3):305-308. doi:10.54005/geneltip.1228775
Chicago
Karpuz, Savaş, Ramazan Yılmaz, Mehmet Özkan, İsmail Hakkı Tunçez, Eser Kalaoğlu, ve Halim Yılmaz. 2023. “Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?”. Genel Tıp Dergisi 33 (3): 305-8. https://doi.org/10.54005/geneltip.1228775.
EndNote
Karpuz S, Yılmaz R, Özkan M, Tunçez İH, Kalaoğlu E, Yılmaz H (01 Haziran 2023) Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis? Genel Tıp Dergisi 33 3 305–308.
IEEE
[1]S. Karpuz, R. Yılmaz, M. Özkan, İ. H. Tunçez, E. Kalaoğlu, ve H. Yılmaz, “Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?”, Genel Tıp Derg, c. 33, sy 3, ss. 305–308, Haz. 2023, doi: 10.54005/geneltip.1228775.
ISNAD
Karpuz, Savaş - Yılmaz, Ramazan - Özkan, Mehmet - Tunçez, İsmail Hakkı - Kalaoğlu, Eser - Yılmaz, Halim. “Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?”. Genel Tıp Dergisi 33/3 (01 Haziran 2023): 305-308. https://doi.org/10.54005/geneltip.1228775.
JAMA
1.Karpuz S, Yılmaz R, Özkan M, Tunçez İH, Kalaoğlu E, Yılmaz H. Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis? Genel Tıp Derg. 2023;33:305–308.
MLA
Karpuz, Savaş, vd. “Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?”. Genel Tıp Dergisi, c. 33, sy 3, Haziran 2023, ss. 305-8, doi:10.54005/geneltip.1228775.
Vancouver
1.Savaş Karpuz, Ramazan Yılmaz, Mehmet Özkan, İsmail Hakkı Tunçez, Eser Kalaoğlu, Halim Yılmaz. Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis? Genel Tıp Derg. 01 Haziran 2023;33(3):305-8. doi:10.54005/geneltip.1228775