Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Dilek Çağlayan; Ramazan Dertli; Melek Çağlayan; Mahmut Selman Yıldırım; Hüseyin Ataseven

doi:10.54005/geneltip.1387463

EN TR

Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Abstract

Background: Ulcerative Colitis is a multifactorial disease which is characterized by recurrent periods of inflammation in the mucosal layer of the colon. Toll-like receptors (TLRs) are a class of transmembrane pattern recognition receptors that play a key role in the induction of pro/anti-inflammatory genes and in the control of adaptive immune responses. In this study, we aimed to evaluate the relation between TLR1(rs4833095) single nucleotide polymorphism and ulcerative colitis. Methods: The study included 90 patients with ulcerative colitis and a healthy control group consisting of 90 people. Taken medical treatment, laboratory data, colonoscopy findings, extraintestinal manifestations of patients included in this study were recorded. TLR1(rs4833095) single nucleotide polymorphism was studied with RT-PCR methods. Results: There was no increased risk for ulcerative colitis in patients with ulcerative colitis who has TLR1(rs4833095) single nucleotide polymorphism in Turkish population (p>0.05). There was no association between TLR 1(rs4833095) single nucleotide polymorphism and the spread of the disease in the colon, severity of disease and treatment required for remission in our study(p>0.05). Conclusion: In the Turkish population, TLR1 (rs4833095) single nucleotide polymorphism was evaluated and no significant difference was found between the patients with ulcerative colitis and the control group.

Keywords

Ulcerative colitis , toll-like receptors , inflammatory bowel disease , single nucleotide polymorphism.

Türk Popülasyonundaki Ülseratif Kolitli Hastalarda TLR1(RS4833095) Gen Polimorfizminin Hastalıkla İlişkisinin Değerlendirilmesi

Öz

Amaç: Ülseratif Kolit, kolonun mukozal tabakasında tekrarlayan inflamasyon dönemleri ile karakterize olan çok faktörlü bir hastalıktır. Toll benzeri reseptörler (TLR'ler), pro/anti-inflamatuar genlerin uyarılmasında ve adaptif immün yanıtların kontrolünde anahtar rol oynayan transmembran, patern tanıma reseptörleridir. Bu çalışmada TLR1(rs4833095) tek nükleotid polimorfizmi ile ülseratif kolit arasındaki ilişkiyi değerlendirmeyi amaçladık. Yöntem: Çalışmaya 90 ülseratif kolit hastası ve 90 kişiden oluşan sağlıklı kontrol grubu dahil edildi. Çalışmaya dahil edilen hastaların aldıkları tıbbi tedaviler, laboratuvar verileri, kolonoskopi bulguları, bağırsak dışı bulguları kaydedildi. TLR1(rs4833095) tek nükleotid polimorfizmi RT-PCR yöntemiyle çalışıldı. Bulgular: Türk toplumunda TLR1(rs4833095) tek nükleotid polimorfizmi olan ülseratif kolit hastalarında ülseratif kolit riskinde artış saptanmadı (p>0,05). Çalışmamızda TLR 1(rs4833095) tek nükleotid polimorfizmi ile hastalığın kolondaki yayılımı, hastalığın şiddeti ve remisyon için gerekli tedavi arasında ilişki saptanmadı(p>0,05). Sonuç: Türk toplumunda TLR1 (rs4833095) tek nükleotid polimorfizmi değerlendirilmiş ve ülseratif kolitli hastalar ile kontrol grubu arasında anlamlı fark saptanmamıştır.

Anahtar Kelimeler

: Ülseratif kolit , toll benzeri reseptörler , inflamatuar barsak hastalığı , tek nükleotid polimorfizmi.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Gastroenteroloji ve Hepatoloji

Bölüm

Araştırma Makalesi

Yazarlar

Dilek Çağlayan ^*
0000-0003-4629-6815
Türkiye

Ramazan Dertli
0000-0002-6205-8983
Türkiye

Melek Çağlayan
0000-0002-6043-4703
Türkiye

Mahmut Selman Yıldırım
0000-0002-3986-5517
Türkiye

Hüseyin Ataseven
0000-0001-9992-4518
Türkiye

Erken Görünüm Tarihi

27 Ekim 2024

Yayımlanma Tarihi

31 Ekim 2024

Gönderilme Tarihi

7 Kasım 2023

Kabul Tarihi

23 Eylül 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 34 Sayı: 5

DOI

https://doi.org/10.54005/geneltip.1387463

IZ

https://izlik.org/JA59TU22BW

Vancouver

1.Dilek Çağlayan, Ramazan Dertli, Melek Çağlayan, Mahmut Selman Yıldırım, Hüseyin Ataseven. Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population. Genel Tıp Derg. 01 Ekim 2024;34(5):603-8. doi:10.54005/geneltip.1387463

Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.

Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Abstract

Keywords

Türk Popülasyonundaki Ülseratif Kolitli Hastalarda TLR1(RS4833095) Gen Polimorfizminin Hastalıkla İlişkisinin Değerlendirilmesi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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