The Relationship Between Rheumatoid Factor Seropositivity and Impulsivity in Rheumatoid Arthritis and the Potential Clinical Effects of Impulsivity
Öz
Background: Impulsivity is the propensity to make judgments and take action without sufficient planning or foreseeing consequences. Impulsivity is one of the main symptoms of several mental disorders. Studies supporting the association between inflammation and impulsivity are increasing in number. This study aimed to assess the association between impulsivity and rheumatoid factor (RF) in rheumatoid arthritis.
Methods: Thirty rheumatoid arthritis patients with RF+ and 22 rheumatoid arthritis patients with RF- were enrolled in this study. Impulsivity was measured using the Barratt Impulsivity Scale (BIS). In addition, Beck Depression Inventory, Beck Anxiety Inventory, Morisky Medication Adherence Scale, Intuitive Eating Scale-2, Health Assessment Questionnaire, and Disease Activity Score-28 were used to evaluate the individuals' clinical features.
Results: In this study, patients with RF+ had higher BIS impulsivity scores than those with RF-. In addition, smoking rates, which may be associated with impulsive behavior, were higher in the RF+ group than in the RF group. Regarding the Morisky Medication Adherence Scale, Beck Anxiety Inventory, Beck Depression Inventory, and Intuitive Eating Scale-2, there was no significant difference between the groups. However, higher scores on impulsivity were positively correlated with higher lymphocyte counts.
Conclusions: These results indicate that RF seropositivity in rheumatoid arthritis is associated with impulsivity. The high impulsivity detected in RF+ patients may be the reason why risky behaviors such as smoking are seen more frequently in this group.
Anahtar Kelimeler
rheumatoid arthritis, rheumatoid factor, inflammation, impulsivity
Etik Beyan
Usak University Medical Ethics Committee for Clinical Studies, Uşak, Turkey (82-82-06) approved the study
Kaynakça
- Krijbolder DI, Verstappen M, van Dijk BT, Dakkak YJ, Burgers LE, Boer AC, et al. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet. 2022;400:283-94.
- Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev. 2021;20:102776.
- Trabelsi M, Romand X, Gilson M, Vaillant M, Guerne PA, Hayem G, et al. Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review. J Clin Med. 2020;9.
- Alexander SK, Di Cicco M, Pohl U, Cifelli A. Rheumatoid disease: an unusual cause of relapsing meningoencephalitis. BMJ Case Rep. 2018;2018.
- Inan AS, Masatlioglu S, Ozyurek SC, Engin D, Erdem I. Unusual central nervous system involvement of rheumatoid arthritis: successful treatment with steroid and azathioprine. Rheumatol Int. 2011;31:1383-5.
- Markenson JA, McDougal JS, Tsairis P, Lockshin MD, Christian CL. Rheumatoid meningitis: a localized immune process. Ann Intern Med. 1979;90:786-9.
- Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094-108.
- Tillmann T, Krishnadas R, Cavanagh J, Petrides KV. Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study. Arthritis Res Ther. 2013;15:R45.
- Ho RC, Fu EH, Chua AN, Cheak AA, Mak A. Clinical and psychosocial factors associated with depression and anxiety in Singaporean patients with rheumatoid arthritis. Int J Rheum Dis. 2011;14:37-47.
- Stanciu I, Anderson J, Siebert S, Mackay D, Lyall DM. Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank. Sci Rep. 2022;12:19844.