Kronik Böbrek Hastalarında Arteriyel Sertlik ve İlişkili Olduğu Faktörler

Yıl 2025, Cilt: 35 Sayı: 6, 1046 - 1062, 31.12.2025

Zeynep İclal Turgut , Gülperi Çelik

https://doi.org/10.54005/geneltip.1421757

Öz

Özet
Amaç: Bu çalışma, kronik böbrek hastalığı (KBH) olan ve olmayan bireylerde arteriyel sertlik parametrelerini augmentasyon indeksi (AIx) ve nabız dalga hızı (PWV) değerlerini karşılaştırmayı ve bu parametreleri etkileyen faktörleri belirlemeyi amaçlamaktadır.
Gereç ve Yöntem: Çalışmaya KBH olan 69 ve olmayan 106 hasta dahil edilmiştir. Her iki grup arasında klinik ve laboratuvar parametreleri ile 24 saatlik ambulatuvar kan basıncı izlemi yoluyla elde edilen PWV ve AIx değerleri karşılaştırılmıştır.
Bulgular: PWV değerleri, 24 saatlik, gündüz ve gece ölçümleri dahil olmak üzere KBH grubunda, KBH olmayan gruba göre anlamlı olarak daha yüksek bulunmuştur (tüm p<0.001). KBH 'lı bireyler arasında, PWV yaş, sistolik kan basıncı (SBP) ve augmentasyon indeksi (AIx) ile pozitif, nabız hızı ile ise negatif bir ilişki ortaya koymuştur. AIx değerleri gruplar arasında anlamlı bir fark göstermemekle birlikte, kadın cinsiyet, lipid profilleri ve hemoglobin seviyeleri gibi demografik ve klinik faktörlerle ilişkili bulunmuştur. Çok değişkenli regresyon modelleri, yaş ve ilaç sayısının PWV ile bağımsız olarak ilişkili olduğunu, yaş, hemoglobin seviyeleri ve cinsiyetin ise AIx ile bağımsız olarak ilişkili parametreler olduğunu ortaya koymuştur.
Sonuç: Çalışmamız, KBH'lı bireylerde PWV'nin anlamlı derecede yüksek olduğunu saptamıştır ve bu durum, PWV'nin arteriyel sertliğin değerlendirilmesinde önemli bir gösterge olduğunu desteklemektedir. PWV ve AIx gibi parametrelerin kullanımı, kişiselleştirilmiş risk değerlendirmelerine katkıda bulunabilir ve KBH'nın klinik yönetimini iyileştirebilir.

Anahtar Kelimeler

Konik Böbrek Hastalığı , Santral Kan Basıncı , Arteriyel sertlik

Arterial Stiffness and Related Factors in Patients with Chronic Kidney Disease

Öz

Abstract
Background: This study aims to compare arterial stiffness parameters, augmentation index (AIx), and pulse wave velocity (PWV) between patient groups with and without chronic kidney disease (CKD) and analyze the factors influencing these parameters.
Materials and methods: This study included 69 patients with CKD and 106 without CKD. All clinical and laboratory parameters and PWV and AIx values obtained from 24-hour ambulatory blood pressure monitoring were compared between the two groups.
Results: PWV values, including 24-hour, daytime, and nighttime measurements, were significantly higher in the CKD group than the non-CKD (all p<0.001). Among individuals with CKD, PWV showed a positive correlation with age, systolic blood pressure (SBP), and augmentation index (AIx), while a negative correlation was observed with pulse rate. AIx values did not show significant differences between the groups; however, they were found to be associated with demographic and clinical factors such as female sex, lipid profiles, and hemoglobin levels. Multivariable regression models revealed that age and the number of medications were independently associated with PWV, while age, hemoglobin levels, and gender were independently associated with AIx.
Conclusion: Our study identified significantly higher PWV values among individuals with CKD, confirming its role as an important indicator of arterial stiffness. The use of parameters such as PWV and AIx may contribute to personalized risk assessments and improve the clinical management of CKD.

Anahtar Kelimeler

Chronic Kidney Disease , Central Blood Pressure , Arterial Stiffness

Etik Beyan

Ethical approval statement: The protocol of this study was approved by the Local Ethical Committee of Selcuk University School of Medicine (number: 2016/12; date: 29 June 2016).

Destekleyen Kurum

No funding was received for this research

Teşekkür

The authors gratefully acknowledge Prof. Dr. Muhammet Cemal Kızılarslanoğlu and Dr. Gülay Şahiner Önal for their valuable academic support and advice

Kaynakça

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