Arterial Stiffness and Related Factors in Patients with Chronic Kidney Disease
Öz
Abstract
Background: This study aims to compare arterial stiffness parameters, augmentation index (AIx), and pulse wave velocity (PWV) between patient groups with and without chronic kidney disease (CKD) and analyze the factors influencing these parameters.
Materials and methods: This study included 69 patients with CKD and 106 without CKD. All clinical and laboratory parameters and PWV and AIx values obtained from 24-hour ambulatory blood pressure monitoring were compared between the two groups.
Results: PWV values, including 24-hour, daytime, and nighttime measurements, were significantly higher in the CKD group than the non-CKD (all p<0.001). Among individuals with CKD, PWV showed a positive correlation with age, systolic blood pressure (SBP), and augmentation index (AIx), while a negative correlation was observed with pulse rate. AIx values did not show significant differences between the groups; however, they were found to be associated with demographic and clinical factors such as female sex, lipid profiles, and hemoglobin levels. Multivariable regression models revealed that age and the number of medications were independently associated with PWV, while age, hemoglobin levels, and gender were independently associated with AIx.
Conclusion: Our study identified significantly higher PWV values among individuals with CKD, confirming its role as an important indicator of arterial stiffness. The use of parameters such as PWV and AIx may contribute to personalized risk assessments and improve the clinical management of CKD.
Anahtar Kelimeler
Chronic Kidney Disease, Central Blood Pressure, Arterial Stiffness
Destekleyen Kurum
No funding was received for this research
Etik Beyan
Ethical approval statement: The protocol of this study was approved by the Local Ethical Committee of Selcuk University School of Medicine (number: 2016/12; date: 29 June 2016).
Teşekkür
The authors gratefully acknowledge Prof. Dr. Muhammet Cemal Kızılarslanoğlu and Dr. Gülay Şahiner Önal for their valuable academic support and advice
Kaynakça
- 1. Hamrahian SM, Falkner B. Hypertension in chronic kidney disease. Hypertension: from basic research to clinical practice 2017: 307-25.
- 2. Hebert SA, Ibrahim HN. Hypertension management in patients with chronic kidney disease. Methodist DeBakey Cardiovascular Journal 2022; 18: 41.
- 3. McEniery CM, Wallace S, Mackenzie IS, et al. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 2006; 48: 602-08.
- 4. Briet M, Boutouyrie P, Laurent S, London GM. Arterial stiffness and pulse pressure in CKD and ESRD. Kidney international 2012; 82: 388-400.
- 5. Mozos I, Maidana JP, Stoian D, Stehlik M. Gender differences of arterial stiffness and arterial age in smokers. International journal of environmental research and public health 2017; 14: 565.
- 6. Hashimoto J, Watabe D, Kimura A, et al. Determinants of the second derivative of the finger photoplethysmogram and brachial-ankle pulse-wave velocity: the Ohasama study. American journal of hypertension 2005; 18: 477-85.
- 7. Hoshide S, Suzuki D, Kario K. Circadian variation and arterial stiffness in chronic kidney disease and their treatment. American Journal of Hypertension 2021; 34: 456-58.
- 8. Matsui Y, Eguchi K, Shibasaki S, et al. Impact of arterial stiffness reduction on urinary albumin excretion during antihypertensive treatment: the Japan morning Surge-1 study. Journal of hypertension 2010; 28: 1752-60.
- 9. Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. Journal of hypertension 2012; 30: 445-48.
- 10. Zanchetti A, Bond MG, Hennig M, et al. Risk factors associated with alterations in carotid intima—media thickness in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis. Journal of hypertension 1998; 16: 949-61.