Evaluation of C-Reactive Protein to Albumin Ratio and Systemic Inflammation in Postmenopausal Osteoporosis

Yıl 2025, Cilt: 35 Sayı: 2, 334 - 339, 30.04.2025

Esra Şahingöz Bakırcı , Mustafa Bakırcı

https://doi.org/10.54005/geneltip.1439038

Öz

Aim
We aimed to evaluate systemic inflammation in patients with postmenopausal osteoporosis using C-reactive protein (CRP)/albumin ratio, blood neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI) and to determine its relationship with bone mineral density (BMD).
Methods
Our study has a retrospective design. A total of 363 postmenopausal female patients admitted to physical medicine and rehabilitation outpatient clinics were evaluated. Patients were divided into three groups as osteoporosis, osteopenia and normal BMD. Demographic data, femoral neck and lumbar total T scores, BMD values, complete blood count parameters, CRP and albumin results were recorded. CRP/albumin ratio, NLR and PNI were calculated.
Results
Osteoporosis was found in 102, osteopenia in 167 and normal BMD in 94 patients. In the osteoporosis group, albumin, CRP and CRP/albumin ratio were lower than the normal BMD group (p = 0.017; p < 0.001; p = 0.032, respectively). In the osteoporosis group, PNI was lower than the other groups (p < 0.001). NLR was higher in the osteoporosis group than the other groups, but not statistically significant (p = 0.723). We found a positive correlation between BMD with albumin and PNI.
Conclusion
The effect of inflammatory response in postmenopausal osteoporosis is not prominent. CRP/albumin ratio does not seem to be an appropriate index for osteoporosis. In the light of our data, nutritional factors seem to be more effective on osteoporosis.

Anahtar Kelimeler

albumin , CAR , inflmammation , osteoporosis , PNI

Postmenopozal Osteoporozda C-Reaktif Protein/Albümin Oranı ve Sistemik İnflamasyonun Değerlendirilmesi

Öz

Amaç
Postmenopozal osteoporoz tanılı hastalarda sistemik inflamasyonu; C-reaktif protein (CRP)/albümin oranı, kan nötrofil/lenfosit oranı (NLO) ve prognostik nütrisyonel indeks (PNİ) ile değerlendirmek ve kemik mineral yoğunluğu (KMY) ile ilişkisini saptamak amaçlandı.
Yöntem
Çalışmamız retrospektif bir tasarıma sahiptir. Fiziksel tıp ve rehabilitasyon polikliniklerine başvuran 363 postmenopozal kadın hasta değerlendirilmeye alındı. Hastalar osteoporoz, osteopeni ve normal KMY olarak üç gruba ayrıldı. Hastaların demografik verileri, femur boyun ve lomber total T skorları ile KMY değerleri, tam kan sayımı ölçümü parametreleri, CRP ve albümin sonuçları kaydedildi. CRP/albümin oranı, NLO ve PNİ hesaplandı.
Bulgular
Hastaların 102’sinde osteoporoz, 167’sinde osteopeni ve 94’ünde normal KMY saptandı. Osteoporoz grubunda; albümin, CRP ve CRP/albümin oranı, normal KMY grubundan düşüktü (sırasıyla p = 0,017; p < 0,001; p = 0,032). Osteoporoz grubunda; PNİ diğer gruplardan daha düşüktü (p < 0,001). NLO ise osteoporoz grubunda diğer gruplardan yüksek olmakla beraber istatistiksel olarak anlamlı değildi (p = 0,723). KMY ile albümin ve PNİ arasında pozitif korelasyon saptadık.
Sonuç
Postmenopozal osteoporozda inflamatuar yanıtın etkisi ön plana çıkmamaktadır. CRP/albümin oranı, osteoporoz için uygun bir indeks olarak görünmemektedir. Verilerimiz ışığında daha çok nütrisyonel faktörler osteoporoz üzerinde etkili görünmektedir.

Anahtar Kelimeler

Albümin , CAR , inflamasyon , osteoporoz , PNİ

Kaynakça

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