Evaluation of C-Reactive Protein to Albumin Ratio and Systemic Inflammation in Postmenopausal Osteoporosis
Öz
Aim
We aimed to evaluate systemic inflammation in patients with postmenopausal osteoporosis using C-reactive protein (CRP)/albumin ratio, blood neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI) and to determine its relationship with bone mineral density (BMD).
Methods
Our study has a retrospective design. A total of 363 postmenopausal female patients admitted to physical medicine and rehabilitation outpatient clinics were evaluated. Patients were divided into three groups as osteoporosis, osteopenia and normal BMD. Demographic data, femoral neck and lumbar total T scores, BMD values, complete blood count parameters, CRP and albumin results were recorded. CRP/albumin ratio, NLR and PNI were calculated.
Results
Osteoporosis was found in 102, osteopenia in 167 and normal BMD in 94 patients. In the osteoporosis group, albumin, CRP and CRP/albumin ratio were lower than the normal BMD group (p = 0.017; p < 0.001; p = 0.032, respectively). In the osteoporosis group, PNI was lower than the other groups (p < 0.001). NLR was higher in the osteoporosis group than the other groups, but not statistically significant (p = 0.723). We found a positive correlation between BMD with albumin and PNI.
Conclusion
The effect of inflammatory response in postmenopausal osteoporosis is not prominent. CRP/albumin ratio does not seem to be an appropriate index for osteoporosis. In the light of our data, nutritional factors seem to be more effective on osteoporosis.
Anahtar Kelimeler
Kaynakça
- 1. de Villiers TJ. Bone health and menopause: Osteoporosis prevention and treatment. Best Pract Res Clin Endocrinol Metab. 2024;38(1):101782.
- 2. Mun H, Liu B, Pham THA, Wu Q. C-reactive protein, and fracture risk: an updated systematic review and meta-analysis of cohort studies through the use of both frequentist and Bayesian approaches. Osteoporos Int. 2021;32(3):425-435.
- 3. Lisco G, Triggiani D, Giagulli VA, De Pergola G, Guastamacchia E, Piazzolla G, et al. Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal Osteoporosis. Is there a Therapeutic Role in Natural Products? Endocr Metab Immune Disord Drug Targets. 2023;23(10):1278-1290.
- 4. Wu D, Cline-Smith A, Shashkova E, Perla A, Katyal A, Aurora R. T-Cell Mediated Inflammation in Postmenopausal Osteoporosis. Front Immunol. 2021;12:687551.
- 5. Guder C, Gravius S, Burger C, Wirtz DC, Schildberg FA. Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System. Front Immunol. 2020;11:58.
- 6. Lim HS, Park YH, Kim SK. Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults. J Bone Metab. 2016;23(1):27-33.
- 7. Harmer D, Falank C, Reagan MR. Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma. Front Endocrinol (Lausanne). 2018;9:788.
- 8. Gremese E, Bruno D, Varriano V, Perniola S, Petricca L, Ferraccioli G. Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice. J Clin Med. 2023;12(18):6017.
- 9. Sunar I, Ataman S. Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Arch Rheumatol. 2020;35(2):247-253.
- 10. Öz N, Gezer H, Duruöz M. AB0232 The Usefulness of the Prognostic Nutritional Index (PNI) for the Disease Activity in Patients with Rheumatoid Arthritis. 2022.