Acil Servise Başvuran ve Pnömoni Tanısı ile Yoğun Bakıma Yatan Hastalarda RDW/Albumin ve BUN/Kreatinin Oranının Mortaliteyi Göstermedeki Gücü
Yıl 2025,
Cilt: 35 Sayı: 6, 1072 - 1080, 31.12.2025
Nazım Onur Can
,
Şenol Arslan
,
Furkan Akpınar
,
Halil İbrahim Doru
Öz
ÖZET
Amaç: Pnömoni tüm dünyada en önemli mortalite ve morbidite nedenlerinden biridir. Pnömoni hastalarının acil servislerde prognozunu belirlemede kullanabileceğimiz daha basit ve kolay belirteçlere ihtiyaç vardır. Biz bu çalışmamızda acil servise başvuran ve pnömoni tanısı ile yoğun bakıma yatırılan hastalarda RDW/Albümin ve BUN/Kreatinin oranı ile 30 günlük mortalite, hastanede kalış süresi ve entübasyon ihtiyacı arasındaki ilişkiyi değerlendirmeyi amaçladık.
Yöntemler: Çalışmaya Ocak 2022- Aralık 2023 tarihleri arasında acil servise başvuran ve pnömoni sebebi ile yoğun bakıma yatırılan 98 hasta dahil edildi. Hastalar taburcu ve ex olan hastalar olmak üzere iki gruba ayrıldı. Gruplar arasında RDW/Albümin ve BUN/Kreatinin oranlarının mortalite ile olan ilişkisi karşılaştırıldı.
Bulgular: Çalışmadan elde ettiğimiz bulgulara göre RDW/Albumin oranının acil servisten yoğun bakıma yatışı yapılan hastalarda mortaliteyi anlamlı şekilde öngördüğü bulunmuştur. Elde edilen diğer bir bulguda ise BUN/Kreatinin oranının da mortaliteyi istatistiksel olarak anlamlı şekilde öngördüğü belirlenmiştir (p<0,05). Çalışmada ayrıca BUN/Kreatinin oranı ile yatış süresi arasında ve yine CRP ile yatış süresi arasında düşük düzeyde pozitif yönlü bir ilişki bulunmuştur. Çalışmamızda albumin seviyesinin entübe olan grupta düştüğü, BUN (p=0,001), kreatinin (p=0,028) ve CRP'nin (p<0,001) ise entübe olan grupta yüksek ve anlamlı olduğu bulunmuştur.
Sonuç: Çalışmamızda RDW/Albümin ve BUN/Kreatinin oranlarının pnömoni hastalarında 30 günlük mortalite tahmininde kullanılabilecek parametreler olduğunu tespit ettik.
Kaynakça
-
1. Bennett JE, Dolin R, Blaser MJ. (2014), Mandell, Douglasand Bennett's Principles and Practice of Infectious Diseases E-Book: 2-Volume Set. Elsevier health sciences.
-
2. File TM. Community-acquired pneumonia. The Lancet. 2003; 362(9400): 1991-2001.
-
3. Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, et al. Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Resp Crit Care Med. 2001; 163(7): 1730-1754.
-
4. Lee JH, Chung HJ, Kim K, Jo YH, Rhee JE, Kim YJ, et al. Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am J Emerg Med. 2013; 31(1): 72-79.
-
5. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015; 52(2): 86-105.
-
6. Quinlan GJ, Martin GS, Evans TW. Albumin: biochemical properties and therapeutic potential. Hepatology. 2005; 41(6): 1211-1219.
-
7. Aman J, van der Heijden M, van Lingen A, Girbes AR, van Nieuw Amerongen GP, van Hinsbergh VW, et.al. Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome. Crit Care Med 2011; 39(1): 89-97.
-
8. Jeong JH, Heo M, Lee SJ, Jeong YY, Lee JD, Yoo JW. Clinical usefulness of red cell distribution width/albumin ratio to discriminate 28-day mortality in critically ill patients with pneumonia receiving invasive mechanical ventilation, compared with lacate/albumin ratio: a retrospective cohort study. Diagnostics. 2021;11(12):2344.
-
9. Özdemir A, Yüksel M, Ay MO, Kaya H, Doğru Ü, Bulut M. Investigation of the Relationship between Blood Urea Nitrogen/Serum Albumin Ratio and Clinical Course in Patients with COVID-19 Pneumonia. Kocaeli Medical Journal. 2022; 11(3): 157-171.
-
10. Lamberink HJ, Otte WM, Sinke MR, Lakens D, Glasziou PP, Tijdink JK, et al. Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 2014. Journal of Clinical Epidemiology. 2018; 102: 123-128.
-
11. Chen L, Lu XY, Zhu CQ. Prognostic value of albumin-red cell distribution width score in patients with severe community-acquired pneumonia. Ann Palliat Med. 2020; 9(3): 759-765.
-
12. Harimurti, K, Setiati S. C-reactive protein levels and decrease of albumin levels in hospitalized elderly patients with community-acquired pneumonia. Acta Med Indones. 2007; 39(1): 13-8.
-
13. Doruk S, Bulaç S, Sevinç C, Bodur AH, Yılmaz A, Erkorkmaz Ü ve ark. Yoğun bakımda izlenen toplum kökenli pnömoni olgularının hastalık ağırlık skorlamaları ve mortalite üzerine etkili faktörler. Tuberkuloz ve Toraks Dergisi. 2009; 57(4): 393-400.
-
14. Bartlett JG, Dowell SF, MandellL A, File Jr TM, Fine MJ. Practice guidelines for the management of community-acquired pneumonia in adults. Clin Infect Dis. 2000; 31(2): 347-382.
-
15. Tapan ÖO, Tapan U. Evaluation of Clinical Course and Treatment Success of Elderly Patients with Community-Acquired Pneumonia Hospitalized and Treated in Accordance with the Guidelines. Turk Thorac J. 2019; 20: 127.
-
16. Bircan A, Kaya Ö, Gökırmak M, Öztürk Ö, Şahin Ü, Akkaya A. Toplum kökenli pnömonilerin ağırlığının değerlendirilmesinde C-reaktif protein, lökosit sayısı ve eritrosit sedimentasyon hızının yeri. Tüberküloz ve Toraks Dergisi. 2006; 54(1): 22-29.
-
17. Almirall J, Bolibar I, Toran P, Pera G, Boquet X, Balanzó X, et al. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest. 2004; 125(4): 1335-1342.
-
18. Lee JH, Kim J, Kim K, Jo YH, Rhee J, Kim TY, et al. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care. 2011; 26(3): 287-294.
-
19. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Emerg Med. 2008; 121(3): 219-225.
-
20. Arihan O, Wernly B, Lichtenauer M, Franz M, Kabisch B, Muessig J, et al. Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU. PloS one. 2018; 13(1): e0191697.
-
21. Ugajin M, Yamahi K, Wamra N, et al, Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquıred pneumonia, J Gen Intern Med. 2012; 5: 583.
The Power of RDW/Albumin and BUN/Creatinine Ratio in Predicting Mortality in Patients Admitted to the Emergency Department and Hospitalized in Intensive Care Unit with Pneumonia
Yıl 2025,
Cilt: 35 Sayı: 6, 1072 - 1080, 31.12.2025
Nazım Onur Can
,
Şenol Arslan
,
Furkan Akpınar
,
Halil İbrahim Doru
Öz
ABSTRACT
Background/Aims: Pneumonia is one of the most important causes of mortality and morbidity worldwide. There is a need for simpler and easier markers that we can use to determine the prognosis of pneumonia patients in emergency departments. In this study, we aimed to evaluate the relationship between RDW/Albumin and BUN/Creatinine ratio and 30-day mortality, length of hospital stay and need for intubation in patients admitted to the emergency department and hospitalized in intensive care unit with a diagnosis of pneumonia.
Methods: The study included 98 patients admitted to the emergency department between January 2022 and December 2023 and hospitalized in the intensive care unit due to pneumonia. Patients were divided into two groups as discharged and exited patients. The relationship between RDW/Albumin and BUN/Creatinine ratios and mortality was compared between the groups.
Results: According to the findings of the study, RDW/Albumin ratio was found to significantly predict mortality in patients hospitalized from the emergency department to the intensive care unit. Another finding was that the BUN/Creatinine ratio also significantly predicted mortality (p<0.05). In the study, a low level positive correlation was found between BUN/Creatinine ratio and length of hospitalization and between CRP and length of hospitalization. In our study, it was found that albumin level decreased in the intubated group, while BUN (p=0.001), creatinine (p=0.028) and CRP (p<0.001) were high and significant in the intubated group.
Conclusion: In our study, we found that RDW/Albumin and BUN/Creatinine ratios are parameters that can be used to predict 30-day mortality in pneumonia patients.
Kaynakça
-
1. Bennett JE, Dolin R, Blaser MJ. (2014), Mandell, Douglasand Bennett's Principles and Practice of Infectious Diseases E-Book: 2-Volume Set. Elsevier health sciences.
-
2. File TM. Community-acquired pneumonia. The Lancet. 2003; 362(9400): 1991-2001.
-
3. Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, et al. Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Resp Crit Care Med. 2001; 163(7): 1730-1754.
-
4. Lee JH, Chung HJ, Kim K, Jo YH, Rhee JE, Kim YJ, et al. Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am J Emerg Med. 2013; 31(1): 72-79.
-
5. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci. 2015; 52(2): 86-105.
-
6. Quinlan GJ, Martin GS, Evans TW. Albumin: biochemical properties and therapeutic potential. Hepatology. 2005; 41(6): 1211-1219.
-
7. Aman J, van der Heijden M, van Lingen A, Girbes AR, van Nieuw Amerongen GP, van Hinsbergh VW, et.al. Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome. Crit Care Med 2011; 39(1): 89-97.
-
8. Jeong JH, Heo M, Lee SJ, Jeong YY, Lee JD, Yoo JW. Clinical usefulness of red cell distribution width/albumin ratio to discriminate 28-day mortality in critically ill patients with pneumonia receiving invasive mechanical ventilation, compared with lacate/albumin ratio: a retrospective cohort study. Diagnostics. 2021;11(12):2344.
-
9. Özdemir A, Yüksel M, Ay MO, Kaya H, Doğru Ü, Bulut M. Investigation of the Relationship between Blood Urea Nitrogen/Serum Albumin Ratio and Clinical Course in Patients with COVID-19 Pneumonia. Kocaeli Medical Journal. 2022; 11(3): 157-171.
-
10. Lamberink HJ, Otte WM, Sinke MR, Lakens D, Glasziou PP, Tijdink JK, et al. Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 2014. Journal of Clinical Epidemiology. 2018; 102: 123-128.
-
11. Chen L, Lu XY, Zhu CQ. Prognostic value of albumin-red cell distribution width score in patients with severe community-acquired pneumonia. Ann Palliat Med. 2020; 9(3): 759-765.
-
12. Harimurti, K, Setiati S. C-reactive protein levels and decrease of albumin levels in hospitalized elderly patients with community-acquired pneumonia. Acta Med Indones. 2007; 39(1): 13-8.
-
13. Doruk S, Bulaç S, Sevinç C, Bodur AH, Yılmaz A, Erkorkmaz Ü ve ark. Yoğun bakımda izlenen toplum kökenli pnömoni olgularının hastalık ağırlık skorlamaları ve mortalite üzerine etkili faktörler. Tuberkuloz ve Toraks Dergisi. 2009; 57(4): 393-400.
-
14. Bartlett JG, Dowell SF, MandellL A, File Jr TM, Fine MJ. Practice guidelines for the management of community-acquired pneumonia in adults. Clin Infect Dis. 2000; 31(2): 347-382.
-
15. Tapan ÖO, Tapan U. Evaluation of Clinical Course and Treatment Success of Elderly Patients with Community-Acquired Pneumonia Hospitalized and Treated in Accordance with the Guidelines. Turk Thorac J. 2019; 20: 127.
-
16. Bircan A, Kaya Ö, Gökırmak M, Öztürk Ö, Şahin Ü, Akkaya A. Toplum kökenli pnömonilerin ağırlığının değerlendirilmesinde C-reaktif protein, lökosit sayısı ve eritrosit sedimentasyon hızının yeri. Tüberküloz ve Toraks Dergisi. 2006; 54(1): 22-29.
-
17. Almirall J, Bolibar I, Toran P, Pera G, Boquet X, Balanzó X, et al. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest. 2004; 125(4): 1335-1342.
-
18. Lee JH, Kim J, Kim K, Jo YH, Rhee J, Kim TY, et al. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care. 2011; 26(3): 287-294.
-
19. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Emerg Med. 2008; 121(3): 219-225.
-
20. Arihan O, Wernly B, Lichtenauer M, Franz M, Kabisch B, Muessig J, et al. Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU. PloS one. 2018; 13(1): e0191697.
-
21. Ugajin M, Yamahi K, Wamra N, et al, Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquıred pneumonia, J Gen Intern Med. 2012; 5: 583.