Investigation of Serum Brain-derived neurotrophic factor, Leptin and Ghrelin Levels in Missed Abortion: A Prospective Study
Öz
Objective: The aim of this study is to investigate the relationship between serum leptin, ghrelin and Brain-derived neurotrophic factor (BDNF) in missed abortion.
Method: 34 pregnant women diagnosed with missed abortion and 30 healthy pregnant women were included in this study. The women included in the study were between the ages of 19 and 42. Women in the first and second trimesters were selected in the control and study groups. Pregnant women who did not have a fetal heartbeat in the first 20th week of pregnancy were considered as missed abortion. The serum leptin, ghrelin and BDNF levels of these patients were compared with the serum leptin, ghrelin and BDNF levels of healthy pregnant women with the same gestational age between the two groups.
Results: The median [IQR] serum level of Ghrelin was significantly higher in woman with missed abortion compared to the healthy controls (807.17 [IQR, 540.93 – 1385.61] vs. 267.14 [IQR, 211.63 – 360.65], U=961, p<.001, rrb=0.88 [95% CI: 0.80 to 0.93]). However, no significant differences were observed in serum level BDNF (270.28 [IQR, 196.91 – 639.57] vs. 265.31 [IQR, 171.46 – 422.85], U=394, p=.744, rrb=0.05 [95% CI: –0.25 to 0.35]) and Leptin (0.40 [IQR, 0.27 – 0.62] vs. 0.53 [IQR, 0.29 – 0.65], U=362, p=.847, rrb=0.03 [95% CI: –0.27 to 0.33]) between healthy controls and patients with missed abortion.
Conclusion: In our study, we found that the serum ghrelin level was higher in patients with missed abortion compared to healthy pregnancies. It is important for future studies to further investigate the potential role of ghrelin in the etiopathogenesis of missed abortion.
Anahtar Kelimeler
Missed abortion, BDNF, Ghrelin, Leptin
Destekleyen Kurum
No
Etik Beyan
Approved by the Local Ethics Committee of the Selcuk University Faculty of Medicine with decision number 2024/105
Kaynakça
- 1. Jiang WZ, Yang XL, Luo JR. Risk factors for missed abortion: retrospective analysis of a single institution’s experience. Reprod Biol Endocrinol. 2022;20(1):115.
- 2. Wu HL, Marwah S, Wang P, Wang QM, Chen XW. Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis. Sci Rep. 2017;7(1):1664.
- 3. Christian LM, Mitchell AM, Gillespie SL, Palettas M. Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: associations with race, depressive symptoms, and low birth weight. Psychoneuroendocrinology. 2016;74:69-76.
- 4. Fung J, Gelaye B, Zhong QY, Rondon MB, Sanchez SE, Barrios YV, et al. Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression. BMC Psychiatry. 2015;15:1-8.
- 5. Pérez-Pérez A, Toro A, Vilariño-García T, Maymó J, Guadix P, Duenas JL, et al. Leptin action in normal and pathological pregnancies. J Cell Mol Med. 2018;22(2):716-27.
- 6. Lindsay KL, Mashayekh JT, Rodriguez N, Gyllenhammer LE. Relationship between psychological stress and ghrelin concentrations in pregnant women with overweight or obesity. Psychoneuroendocrinology. 2022;146:105937.
- 7. Fuglsang J. Ghrelin in pregnancy and lactation. Vitam Horm. 2007;77:259-84.
- 8. Muccioli G, Lorenzi T, Lorenzi M, Ghè C, Arnoletti E, Raso GM, et al. Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function. Peptides. 2011;32(12):2514-21.
- 9. D'Souza V, Patil V, Pisal H, Randhir K, Joshi A, Mehendale S, et al. Levels of brain-derived neurotrophic factors across gestation in women with preeclampsia. Int J Dev Neurosci. 2014;37:36-40.
- 10. Mayeur S, Lukaszewski MA, Breton C, Storme L, Vieau D, Lesage J. Do neurotrophins regulate the fetoplacental development? Med Hypotheses. 2011;76(5):726-8.