Investigation Of Causing Microorganisms And Antimicrobial Sensitivity Patterns In Diabetic Foot Wounds
Öz
Abstract
Background/Aims: Diabetic foot is the clinical term describing a series of diabetes-related lower extremity complications such as ulceration, infection, and gangrene. Aim of the study is to prospectively investigate the causative aerobic bacteria in diabetic foot ulcer samples, as well as anaerobic bacteria and fungi, which are thought to have an important place in diabetic foot infections. At the same time, the antimicrobial susceptibility of the causative microorganisms obtained from the culture will be investigated.
Methods: 59 samples taken from 50 patients with type 2 Diabetes Mellitus were included in the study. The BD Phoenix TM automated system was used for species-level identification of microorganisms and antimicrobial susceptibility testing. The antimicrobial susceptibility of anaerobic microorganisms was tested with the gradient gradient test method.
Results: It was determined that the most common (65%) agent in DFI was Gram-negative aerobic bacteria and the majority of them (65%) were multidrug resistant. The most common cause of monomicrobial infection is Staphylococcus aureus and the MRSA rate was found to be 27%. The results of the study showed that vancomycin, teicoplanin and linezolid were the most effective antibiotics against Gram-positive agents. The most effective antibiotics against gram-negative agents were found to be ceftolozane/tazobactam, piperacillin/tazobactam, meropenem, ertapenem, colistin and amikacin.
Conclusions: Considering that the majority of Gram-negative agents consist of multidrug resistant microorganisms, the importance of prudent antibiotic use is once again increasing. It should be taken into account that diabetes is a disease that is 80% preventable with lifestyle changes, and the importance of increasing public awareness about healthy living should be emphasized.
Anahtar Kelimeler
Diabetic foot, diabetic foot ulcer, antibiotic susceptibility, microorganism
Destekleyen Kurum
The study was funded by Selçuk University Scientific Research Project (BAP) during the design of the research, data collection, analysis, interpretation and writing of the article (Project no: 22122023).
Etik Beyan
This study was reviewed and approved by the Clinical Investigations Ethics Committee of Selçuk University (No: 2022/64 and Date: 02/03/2022). Signed informed consents of all participants will be obtained.
Kaynakça
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