Examining Subclinical Inflammation in Major Depressive Disorder Subtypes

Yıl 2025, Cilt: 35 Sayı: 6 , 1081 - 1089 , 31.12.2025

Esra Aslan , Bahadır Demir

https://doi.org/10.54005/geneltip.1609236

https://izlik.org/JA28MF24CF

Öz

Aims: There is increasing evidence that neuroinflammation and inflammatory processes play roles in psychiatric disorders. In the present study, the purpose was to investigate the role of systemic inflammation in major depressive disorder (MDD) subtypes, to compare the inflammation rates between subtypes and healthy controls, to help elucidate the pathophysiology of the disease, and to contribute to the determination of biochemical parameters.
Material and Methods: A total of 244 participants (180 patients diagnosed with MDD; 30 from the subtypes of catatonia, melancholy, mixed, atypical, anxious distress, psychosis, and 64 healthy controls )were included in the study. Participants who had a history of comorbid medical disease and/or any medication use were excluded from the study. Hemoglobin, hematocrit, platelets, neutrophils, lymphocytes, monocytes, Monocyte/Lymphocyte Ratio (MLR), Neutrophil/Lymphocyte Ratio (NLR), and Platelet/Lymphocyte Ratio (PLR) of the groups were compared.
Results: Sex, age and Body Mass Index (BMI) values did not differ between MDD subtypes and healthy controls (p>0.05). No differences were detected between healthy controls and MDD subtypes in neutrophil and lymphocyte counts (p>0.05). NLR and MLR values differed between healthy controls and MDD subtypes (p=0.023, p=0.002, respectively). NLR and MLR were significantly higher in the MDD subtype with catatonic characteristics than in healthy controls (p=0.002, p<0.001, respectively).
Conclusion: These results may contribute to a better understanding of subclinical inflammation,

Anahtar Kelimeler

Biomarkers , catatonia , major depressive disorder , monocyte/lymphocyte ratio , subclinical inflammation , neutrophil/lymphocyte ratio , platelet/lymphocyte ratio

Etik Beyan

The study was approved by the ethical commission of Gaziantep University with the decision number 2022/265.

Destekleyen Kurum

None

Teşekkür

None

Majör depresif bozukluk alt tiplerinde subklinik inflamasyonun incelenmesi

https://izlik.org/JA28MF24CF

Öz

Amaç: Psikiyatrik bozukluklarda nöroinflamasyonun ve inflamatuar süreçlerin rol oynadığına dair kanıtlar giderek artmaktadır. Çalışmamızda Majör depresif bozukluk (MDB) alt tiplerinde sistemik inflamasyonun rolünün araştırılması, alt tipler arasındaki inflamasyon oranlarının sağlıklı kontroller ile karşılaştırılması, hastalığın patofizyolojisinin aydınlatılmasına yardımcı olunması, biyokimyasal parametrelerin tespit edilmesine katkı sağlanması amaçlandı.
Gereç ve Yöntem: Çalışmaya MDB tanısı alan 180 hasta (katatoni ile giden, melankoli, karma, atipik, bunaltılı sıkıntı, psikoz özellikleri gösteren alt tiplerin her birinden 30 hasta) ve 64 sağlıklı kontrol olmak üzere 244 katılımcı dahil edildi. Komorbid tıbbi hastalık öyküsü ve/veya herhangi bir ilaç kullanımı olan katılımcılar çalışmaya dahil edilmedi. Grupların hemoglobin, hematokrit, platelet, nötrofil, lenfosit, monosit, monosit/lenfosit oranı (MLO), nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO) karşılaştırıldı.
Bulgular: Cinsiyet, yaş ve vücut kitle indeksi (VKİ) değerleri; MDB alt tipleri ile sağlıklı kontroller
arasında farklılık göstermedi (p>0.05). Nötrofil ve lenfosit sayıları açısından sağlıklı kontroller ve MDB alt tipleri arasında fark saptanmadı (p>0.05). NLO ve MLO değerleri sağlıklı kontroller ile MDB alt tipleri arasında farklılık gösterdi (sırasıyla p=0.023, p=0.002). Katatonik özellikli MDB alt tipinde NLO ve MLO sağlıklı kontrollere göre anlamlı düzeyde yüksek saptandı (sırasıyla p=0.002, p<0.001).
Sonuç: Araştırmamızın bulguları MDB alt tiplerinde subklinik inflamasyonun, patofizyolojinin, bireyselleştirilmiş tedavi yaklaşımlarının ve prognostik değerlendirmenin daha iyi anlaşılmasına katkıda bulunabilir.

Anahtar Kelimeler

Biyobelirteçler , katatoni , majör depresif bozukluk , monosit/lenfosit oranı , nötrofil/ lenfosit oranı , platelet/lenfosit oranı , subklinik inflamasyon

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