Recurrent Wheezing in Preschoolers: Association Between Peripheral Blood Cell-Derived Inflammatory Indexes and the Asthma Predictive
Öz
Objective: The current study aimed to determine the role of chronic and eosinophilic inflammation in the etiopathogenesis of recurrent wheezing in preschool children and to evaluate the relationship between these inflammatory parameters and the Modified Asthma Predictive Index (mAPI) in positive and negative groups.
Materials and Methods: The study included patients under six years old who presented with recurrent wheezing complaints to pediatric immunology and allergy clinics between September 2022 and September 2023 and had not yet started asthma treatment. Demographic data such as age, gender, atopy history, and smoking exposure, along with complete blood count, total IgE levels, and aeroallergen sensitivity, were analyzed. Patients were categorized into two groups based on mAPI positivity and negativity.
Results: The mAPI-positive group had significantly higher eosinophil count (p=0.004), eosinophil percentage (p=0.034), eosinophil/lymphocyte ratio (p=0.01), eosinophil/neutrophil ratio (p=0.007), and eosinophil/monocyte ratio (p<0.001). A significant positive correlation was found between basophil and eosinophil counts (p=0.001, r=0.31). No statistical differences were observed between groups regarding hospitalization rates, oral corticosteroid use, or emergency visits.
Conclusion: Our study demonstrated that hematological parameters indicative of eosinophilic inflammation were significantly elevated in the mAPI-positive preschool children with recurrent wheezing. Additionally, basophils may play a role in chronic inflammation alongside eosinophils. Larger cohort studies are needed to further investigate the asthma risk in this patient population.
Anahtar Kelimeler
Recurrent wheezing, preschool children, asthma predictive index, inflammation
Kaynakça
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